Publications by authors named "Tung V Le"
Introduction And Importance: Uterine torsion are extremely rare in pregnancy as few cases have been reported. Torsion of the pregnant uterus is defined as the rotation more than 45 degrees around the long axis of the uterus. It has been referred as, once-in-a-lifetime diagnosis by obstetricians and gynecologists.
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- A new method for producing (S)-(+)-3-aminomethyl-5-methylhexanoic acid, also known as Pregabalin, is presented.
- The process involves a crucial step where a specific acid salt undergoes asymmetric hydrogenation using a rhodium catalyst, resulting in a high enantiomeric excess for the desired compound.
- A follow-up hydrogenation of the product's nitrile using a nickel catalyst yields Pregabalin with excellent yield and purity.