Planetary Health Diet Index Trends and Associations with Dietary Greenhouse Gas Emissions, Disease Biomarkers, Obesity, and Mortality in the United States (2005-2018).

Background: Diet plays a vital role in human health and environmental effects. Monitoring diet quality and its relationship to both health and environment are essential for policy making.

Objectives: This study aimed to analyze trends in the Planetary Health Diet Index (PHDI) and its associations with daily greenhouse gas emissions from food (GHG), disease-related biomarkers, anthropometric measurements, obesity, and all-cause mortality in the US population.

An appropriate DNA input for bisulfite conversion reveals LINE-1 and Alu hypermethylation in tissues and circulating cell-free DNA from cancers.

The autonomous and active Long-Interspersed Element-1 (LINE-1, L1) and the non-autonomous Alu retrotransposon elements, contributing to 30% of the human genome, are the most abundant repeated sequences. With more than 90% of their sequences being methylated in normal cells, these elements undeniably contribute to the global DNA methylation level and constitute a major part of circulating-cell-free DNA (cfDNA). So far, the hypomethylation status of LINE-1 and Alu in cellular and extracellular DNA has long been considered a prevailing hallmark of ageing-related diseases and cancer.

Hypermethylation at 45S rDNA promoter in cancers.

The ribosomal genes (rDNA genes) encode 47S rRNA which accounts for up to 80% of all cellular RNA. At any given time, no more than 50% of rDNA genes are actively transcribed, and the other half is silent by forming heterochromatin structures through DNA methylation. In cancer cells, upregulation of ribosome biogenesis has been recognized as a hallmark feature, thus, the reduced methylation of rDNA promoter has been thought to support conformational changes of chromatin accessibility and the subsequent increase in rDNA transcription.

Resuscitation from Respiratory Arrest Due to Life-Threatening Ventricular Arrhythmias in a Patient with Amitriptyline Intoxication: An Old Problem in a New Era.

Introduction: Tricyclic antidepressants (TCAs) were once commonly used to treat major depressive disorder (MDD), but are now considered second-line options after SSRIs and SNRIs. Additionally, TCAs are used to treat other conditions such as chronic pain and enuresis in children. Due to their numerous side effects and potential for drug interactions, cases of poisoning and death from TCA overdose, particularly amitriptyline, are on the rise.

Influence of chickpea protein on the pH and temperature dependent viscosity of carboxymethylated starch.

Proteins can significantly improve the elasticity and microstructure of starch gels in food. In this work, the influence of chickpea protein flour on the viscoelastic behaviour of carboxymethylated starch (CMS, 92.6 mmol COOH kg) gels was studied as function of pH and temperature.

Effective treatment of 2,4,6-trinitrotoluene from aqueous media using a sono-photo-Fenton-like process with a zero-valent iron nanoparticle (nZVI) catalyst.

In this study, we examine the effectiveness of using a combination of a sono-photo-Fenton-like procedure and nano zero-valent iron catalyst (nZVI) to treat 2,4,6-trinitrotoluene (TNT) in an aquatic environment. Zero-valent iron particles were generated by a chemical reduction technique. nZVI nanoparticles were analyzed using scanning electron microscopy (SEM) and X-ray diffraction (XRD) to characterize the nanocatalyst.

Planetary Health Diet Index and risk of total and cause-specific mortality in three prospective cohorts.

Background: In 2019, the EAT-Lancet Commission proposed a healthy dietary pattern that, along with reductions in food waste and improved agricultural practices, could feed the increasing global population sustainably. We developed a Planetary Health Diet Index (PHDI) to quantify adherence to the EAT-Lancet reference diet.

Objectives: We aimed to assess associations between PHDI and total and cause-specific mortality in 3 prospective cohorts of males and females in the United States.

Opioid Therapy for Cancer Pain in Vietnam: Knowledge, Attitudes, and Perceived Barriers Among Health Care Professionals, Policymakers, and Regulators.

Purpose: We aimed to assess knowledge, attitudes, and perceived barriers among health care professionals (HCPs), policymakers, and regulators in Vietnam related to opioid therapy for cancer pain.

Methods: We conducted a cross-sectional study in Vietnam from June to August 2022. Participants completed a questionnaire on their demographic characteristics, knowledge and attitudes toward opioid therapy, and barriers to accessing opioids for cancer pain.

Application of the Hollow-Fiber Infection Model to Personalized Precision Dosing of Isoniazid in a Clinical Setting.

Background: The hollow-fiber infection model (HFIM) is a valuable tool for evaluating pharmacokinetics/pharmacodynamics relationships and determining the optimal antibiotic dose in monotherapy or combination therapy, but the application for personalized precision medicine in tuberculosis treatment remains limited. This study aimed to evaluate the efficacy of adjusted antibiotic doses for a tuberculosis patient using HFIM.

Methods: Model-based Bayesian forecasting was utilized to assess the proposed reduction of the isoniazid dose from 300 mg daily to 150 mg daily in a patient with an ultra-slow-acetylation phenotype.

Multifunctional Polypyrrole-Based Textile Sensors for Integration into Personal Protection Equipment.

Integrated safety sensors for personal protection equipment increasingly attract research activities as there is a high need for workers in delicate situations to be physically monitored in order to avoid accidents. In this work, we present a simple approach to generate thin, homogeneous polypyrrole (PPy) layers on flexible textile polyamide fabrics. PPy layers of 0.

Natural Fiber Reinforced Shoe Midsoles with Balanced Stiffness/Damping Behavior.

The comfort of walking depends heavily on the shoes used. Consequently, the midsole of shoes is designed in such a way that it can dampen force peaks during walking. This significantly increases the overall wellness during walking.

Polyolefin Blends with Selectively Crosslinked Disperse Phase Based on Silane-Modified Polyethylene.

Polypropylene-based multiphase compositions with a disperse elastomer phase provide superior impact strength. Making this property indifferent to processing steps requires stabilization of the morphology of these materials. Various approaches have been tested over time, each of which shows limitations in terms of performance or applicability.

Cyclic Voltammetry of C.I. Disperse Orange 62 in an Aqueous Electrolyte.

Disperse dyes are an important group of colorants for dyeing polyester fibers. Approximately 30.000 tons of disperse dyes are released into the waste water annually from spent dyebaths.

Imperfect cross-linking of xanthan for pH-responsive bio-based composite moist wound dressings by stencil printing.

The work addresses the use of bio-based and -degradable materials for the production of a moist, adaptive and anti-microbial wound dressing. The dressing is targeted to exhibit a pH-dependent active agent release. Xanthan hydrogel structures are coated on cellulose fabrics via stencil printing and subsequently cross-linked using glyoxal.

Magnetic resonance imaging of pancreatic islets using tissue-adhesive particles containing iron oxide nanoparticles.

Post-transplantation tracking of pancreatic islets is a prerequisite for advancing cell therapy to treat type 1 diabetes. Magnetic resonance imaging (MRI) has emerged as a safe and non-invasive technique for visualizing cells in clinical applications. In this study, we proposed a novel MRI contrast agent formulation by encapsulating iron oxide nanoparticles (IONPs) in poly(lactic-co-glycolic acid) (PLGA) particles functionalized with a tissue adhesive polydopamine (PD) layer (IONP-PLGA-PD MS).

Leaching of nitrogen, phosphorus and other solutes from a controlled drainage cultivated peatland in Ruukki, Finland.

Cultivated peatlands are important for grass production in Northern Europe, but the potential impact of nutrients leaching to surface waters is a major concern. Due to a lack of data on nitrogen (N), phosphorus (P) and organic carbon leaching, a monitoring programme was established at Ruukki (Siikajoki, Finland), an agricultural, subsurface drained peat site with a peat thickness of 20-80 cm. Concentrations and loading of N, P, and total organic carbon (TOC) were monitored, along with other water quality parameters for the field discharge, in 2018-2021.

Improvement of wet rub fastness in continuous dyeing with c.i. Sulphur Black 1 by ultrasonic treatment.

C.I. Sulphur Black 1 is among the most important dyes for cellulose textiles, as this dye offers a maximum colour depth at reasonable costs.

Prevalence of obesity and abdominal obesity and their association with metabolic-related conditions in Vietnamese adults: an analysis of Vietnam STEPS survey 2009 and 2015.

Background: The abdominal obesity trends and prevalence are important contributing factors to significant rise of many noncommunicable diseases in Vietnam but have not been well-documented in the literature. This study aimed to describe the prevalence and trends of obesity and abdominal obesity in Vietnam from 2009 to 2015 and evaluate how different definitions of obesity and abdominal obesity are associated with metabolic-related conditions.

Methods: We conducted a secondary analysis based on the Vietnam STEPS (STEPwise approach to Surveillance) cross-sectional Survey 2009 and 2015.

Panaxindole, a novel indole alkaloid N-glucoside from the leaves of Panax vietnamensis Ha et Grushv. (Vietnamese ginseng).

Vietnamese ginseng (Panax vietnamensis Ha and Grushv., Araliaceae) is indigenous in the central highlands of Vietnam and the southernmost distribution in the Panax genus. Like other ginseng, Vietnamese ginseng is well known has been used as a tonic and for management of certain diseases in the traditional medicine.

Comparative genomics of two Vietnamese Helicobacter pylori strains, CHC155 from a non-cardia gastric cancer patient and VN1291 from a duodenal ulcer patient.

Helicobacter pylori is involved in the etiology and severity of several gastroduodenal diseases; however, plasticity of the H. pylori genome makes complete genome assembly difficult. We report here the full genomes of H.

Proportion and number of cancer cases and deaths attributable to behavioral risk factors in Vietnam.

Identifying modifiable risk factors that contribute to cancer is essential in setting up preventive strategies. Therefore, this study aimed to estimate the number and proportion of cancer cases and deaths attributable to five behavior-related risk factors-tobacco smoking, second-hand smoking, alcohol consumption, high body mass index and insufficient physical activity in Vietnam in 2020. Population attributable fractions were calculated for relationships of risk factors and cancer types based on sufficient evidence according to IARC or strong evidence according to WCRF/AICR.

Climate shocks and responses: Perspectives and experiences of ethnic minority farmers in rural mountainous regions of Central Vietnam.

Ethnic minority farmers (EMFs) in upland areas of Central Vietnam are particularly vulnerable to the impacts of climate shocks and extreme events. It is thus urgent to examine their perceptions of the potential risks, their coping strategies, and the factors influencing their adaptation decisions in agriculture production. By exploring adaptation measures of the Xo Dang and Co Tu EMFs in Quang Nam province, Central Vietnam, the study results reveal that the EMFs are increasingly conscious of local climate shocks in the recent decade; as a result, they have applied multiple specific strategies in agriculture production to mitigate risks.