The Effect of Endometrial Polyp and Myoma Uteri on Fertility-Related Genes in the Endometrium.

Endometrial polyps are hyperplastic overgrowths of the endometrium that contain both glands and stroma. Myoma uteri is the most common benign tumor of the female pelvis and uterus. HOXA10, which is involved during the organogenesis of the uterus in the embryonic period.

Multi-omics analysis of placental metabolomics and transcriptomics datasets reveals comprehensive insights into the pathophysiology of preeclampsia.

Preeclampsia, a life-threatening pregnancy complication, remains a major global health concern. Understanding the complex molecular mechanisms underlying this disorder is crucial for improving both diagnostics and therapeutic strategies. In this study, a multi-omics approach based on NMR metabolomics and RNA-seq transcriptomics analyses was conducted to analyze placental tissue samples obtained from patients with preeclampsia and healthy controls.

Comparison of the characteristics of patients with chronic urticaria receiving standard- or high-dose omalizumab.

In patients whose chronic urticaria (CU) cannot be controlled with omalizumab 300 mg and antihistamines, the dose can be increased up to 600 mg. The study aimed to compare the clinical characteristics of patients receiving 300 mg versus higher doses of omalizumab, and to evaluate baseline predictors for updosing. A total of 159 patients who have been followed up at a tertiary care allergy center and received omalizumab for at least 12 months were included.

The association between baseline IgE level and urticaria control at six months of omalizumab treatment in chronic urticaria.

There is limited data on the use of baseline IgE level as a predictor of omalizumab response in chronic urticaria (CU). The aim of the present study was to determine if baseline serum total IgE level is associated with response at six months of standard-dose omalizumab. The study was designed as a retrospective, single-center, cohort survey.

Introducing the SNW-1 Covalent Organic Framework to the Polyamide Layer of the TFC-RO Membrane with Enhanced Permeability and Desalination Performance.

This study investigates the synthesis and characterization of Schiff base network-1 (SNW-1) covalent organic framework (COF) nanomaterials and their application in the fabrication of thin-film nanocomposite (TFN) membranes. The embedding of SNW-1 COF in reverse osmosis (RO) membranes with a polysulfone (PSf) substrate was done using the interfacial polymerization method. The result of the study demonstrated that the porous and hydrophilic structure of the COF increased the hydrophilic properties of the produced RO membranes.

Successful desensitization in a patient with recurrent anaplastic oligodendroglioma presenting with procarbazine-mediated anaphylaxis.

Introduction: Procarbazine is an oral chemotherapeutic agent used in the treatment of brain malignancies and is associated with hypersensitivity reactions. In case of grade 4 reactions, rechallenge should be avoided, and the agent should be replaced, unless the treatment is curative, in which case the application of a desensitization protocol should be considered. We present a successful case of desensitization in procarbazine anaphylaxis.

Modification of PAN electrospun nanofiber membranes with g-CN nanotubes/carbon dots to enhance MBR performance.

This study is dedicated to the enhancement of electrospun polyacrylonitrile (PAN) nanofiber membranes for their application in membrane bioreactor (MBR) processes. The improvement is achieved through the incorporation of graphitic carbon nitride nanotubes/carbon dots (g-CN NT/CDs) and subsequent heat post-treatments at varying temperatures. Notably, the hot-pressing methodology effectively mitigates surface roughness and significantly reduces issues related to peeling during nanofiber experimentation.

A new hybrid method combining search and direct based construction ideas to generate all 4 × 4 involutory maximum distance separable (MDS) matrices over binary field extensions.

This article presents a new hybrid method (combining search based methods and direct construction methods) to generate all involutory maximum distance separable (MDS) matrices over . The proposed method reduces the search space complexity at the level of , where represents the number of all invertible matrices over to be searched for. Hence, this enables us to generate all involutory MDS matrices over and .

Urticaria exacerbations and adverse reactions in patients with chronic urticaria receiving COVID-19 vaccination: Results of the UCARE COVAC-CU study.

Background: Concern about disease exacerbations and fear of reactions after coronavirus disease 2019 (COVID-19) vaccinations are common in chronic urticaria (CU) patients and may lead to vaccine hesitancy.

Objective: We assessed the frequency and risk factors of CU exacerbation and adverse reactions in CU patients after COVID-19 vaccination.

Methods: COVAC-CU is an international multicenter study of Urticaria Centers of Reference and Excellence (UCAREs) that retrospectively evaluated the effects of COVID-19 vaccination in CU patients aged ≥18 years and vaccinated with ≥1 dose of any COVID-19 vaccine.

Bernard-Soulier Syndrome from the Perspective of the Obstetrician: A Case Report with a Review of the Literature.

Objective: Bernard-Soulier syndrome (BSS) is one of the rare inherited platelet disorders that is characterized by macrothrombocytopenia and adhesion abnormality due to the absence or malfunctioning of the membrane GPIb-IX-V complex. There is no high-quality evidence on obstetric management of BSS owing to its rarity. Here we report an uncomplicated delivery of an adolescent with BSS and review the literature on the topic of BSS and pregnancy.

Investigation of different molecular weight Polyvinylidene Fluoride (PVDF) polymer for the fabrication and performance of braid hollow fiber membranes.

In the current study, braid reinforced membranes were fabricated from polyvinylidene fluoride (PVDF) polymers with two different molecular weights, and the blending of the polymers in a 1:1 ratio to upgrade the performance of the membrane. Characterization, filtration studies, and membrane bioreactor (MBR) application were done to evaluate membrane performance by applying the same operation conditions on each membrane. Characterization studies indicated that the fabricated membrane from blending polymers was a hydrophilic structure with a contact angle of 50.

Sinonasal and respiratory outcomes of eosinophilic granulomatosis with polyangiitis patients receiving 100 mg mepolizumab in real-life clinical practice: 1-year follow up study.

: Mepolizumab 300 mg is an approved treatment option for patients with eosinophilic granulomatosis with polyangiitis (EGPA), yet, the adequacy of 100 mg of mepolizumab in disease control is controversial.: To evaluate the sinonasal and respiratory outcomes of EGPA patients treated with 100 mg mepolizumab for one year.: Evaluations of 11 patients were made of the sinonasal outcome test (SNOT-22) (nasal, otologic, sleep, and emotional domains), asthma control test (ACT), forced expiratory volume in 1 s (FEV1), blood eosinophil counts and oral steroid doses before mepolizumab treatment (T0) and at the 6 (T6) and 12 (T12) months.

Metabolomic analysis of endometrial cancer by high-resolution magic angle spinning NMR spectroscopy.

Purpose: To analyze endometrial metabolite profiles between patients with endometrial cancer and controls.

Methods: Seventeen (17) women with endometrium cancer and 18 controls were enrolled in this study. H HR-MAS (High Resolution-Magic Angle Spinning) NMR (Nuclear Magnetic Resonance) spectroscopy data obtained from endometrial tissue samples of patients with endometrial cancer and control group were analyzed with bioinformatics methods.

The association of timothy grass allergy and cat ownership on cat sensitization.

Pollen hypersensitivity might be a determining factor for other nonseasonal allergens because it may indicate deviation of the immune system toward T-helper type 2 activity and immunoglobulin E sensitivity. To investigate whether timothy grass pollen allergy may be a predictive factor for cat sensitization and whether there is an association between sensitivity to both allergens. A retrospective review was made of patients with symptoms of rhinitis.

Metabolomics analysis of placental tissue obtained from patients with fetal growth restriction.

Aim: The aim of this study was to determine whether there was a difference in placental metabolite profiles between patients with fetal growth restriction (FGR) and healthy controls.

Methods: The study included 10 patients with FGR diagnosis with 14 healthy controls with both matched maternal age and body mass index. H HR-MAS NMR spectroscopy data obtained from placental tissue samples of patients with FGR and healthy control group were analyzed with bioinformatics methods.

The Definition of the Upper Limit of Adolescent Age in Terms of Adverse Pregnancy Outcomes.

Introduction This study aims to reveal the maternal and neonatal adverse outcomes, associated with adolescent pregnancies in our country, to investigate whether the 20 to 21-year-age group, which is very close to the adolescent age, is similar to the adolescent age group in terms of adverse outcomes, and so to contribute to the definition of the upper limit in adolescent age for pregnancy. Methods Four hundred and twenty-four pregnant women under the 20-year-age, 450 pregnant women at 20 to 21-year-age, and 450 pregnant women between 22 and 25-year-age were included in this retrospective study. Maternal demographic features, clinical characteristics, obstetric complications, maternal outcomes, neonatal complications, and neonatal outcomes were collected from the medical records of the participants.

The course of COVID-19 in patients with severe asthma receiving biological treatment.

Objective: In order to decrease the use of systemic corticosteroids and prevent asthma exacerbations, EAACI and GINA made recommendations in favor of severe asthma patients continuing the use of biologicals during the pandemic. However, the course of SARS-CoV-2 infection remains uncertain, especially in patients taking biological therapy for severe asthma. The aim of this study was to demonstrate the clinical course of COVID-19 in severe asthmatic patients receiving biological treatment.

Effect of COVID-19 on hereditary angioedema activity and quality of life.

The demonstration that severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) enters the cell the angiotensin-converting enzyme 2 receptor has raised concerns that, in hereditary angioedema (HAE), a disease characterized by bradykinin-mediated angioedema attacks, coronavirus disease 2019 (COVID-19) may trigger angioedema attacks, increase the frequency and/or severity of attacks, or cause more severe symptoms of COVID-19. The objective was to evaluate the severity of COVID-19 in patients with HAE, the course of HAE attacks, angioedema activity, and the quality-of-life scores during COVID-19 pandemic. Patients diagnosed with HAE for at least 6 months were included in the study.

Effect of solution chemistry on filtration performances and fouling potential of membrane processes for rare earth element recovery from red mud.

Rare earth elements or REEs are a vital and irreplaceable part of our modern technological and digital industries. Among the REEs that are the most critical to be recovered are Ce, La, and particularly, Nd, and Y, due to high demand and at a potential future supply risk. Innovative techniques must be considered to recover REEs from secondary resources.