Publications by authors named "Tuhina Neogi"
Objective: Transcutaneous auricular vagus nerve stimulation () may be an innovative treatment for symptoms of knee osteoarthritis (OA) due to possible shared pathological mechanisms between diminished parasympathetic function, central pain mechanisms, and knee pain. Thus, we sought to test the safety and preliminary efficacy of tVNS in people with knee OA.
Design: A pilot trial in which participants received a 60-min tVNS was conducted.
Objective: We evaluated a behaviorally designed intervention utilizing gamification and social support to improve physical activity and reduce symptoms in patients with osteoarthritis of the knee (KOA).
Methods: Veterans with KOA, aged 40-80 years, were enrolled in this randomized controlled trial. Participants received a Fitbit and completed a 2- to 4-week baseline period.
Article Synopsis
- The study aimed to analyze the disease, demographic, and imaging characteristics linked to different types of calcium pyrophosphate deposition (CPPD) disease, focusing on recurrent acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and crowned dens syndrome (CDS).
- Researchers utilized data from an international cohort of 618 individuals to investigate the phenotypic traits of each type of CPPD and performed multivariable logistic regression to assess associations between risk factors and inflammatory phenotypes.
- Key findings indicated that longer disease duration correlated with recurrent acute arthritis, while chronic arthritis was linked to specific joint issues and less associated with metabolic risks, and CDS was more common in males with greater joint involvement. *
Objective: To describe the use of non-steroidal anti-inflammatory drugs (NSAID), opioids, and physiotherapy (PT) among persons with newly diagnosed knee or hip osteoarthritis (OA) with and without NSAID contraindications or precautions.
Design: We used population-based register data to identify adults aged ≥35 as of January 1, 2014, residing in Skåne region (Sweden) between 2004 and 2013, without a previous knee or hip OA diagnosis. Among this cohort, we identified people with incident knee or hip OA diagnosis between 2014 and 2018 and the presence of contraindications to or precautions for oral NSAIDs at the time of OA diagnosis.
Article Synopsis
- This study aimed to analyze how common existing joint bone issues are in patients with hip or knee pain from osteoarthritis (OA) who were screened for fasinumab clinical trials.
- Out of 27,633 screened participants, 21,997 underwent imaging, and 5.5% were excluded due to severe articular bone problems noted in X-rays or MRIs, such as bone fragmentation and osteonecrosis.
- The results suggest that around 5% of OA patients who qualified for the clinical trials ended up being excluded because of serious preexisting joint conditions detected during imaging tests.
Article Synopsis
- The study aimed to compare the risk of arthritis flares when starting urate-lowering therapy (ULT) with allopurinol versus febuxostat in gout patients, focusing on the first 24 weeks of treatment.
- It analyzed data from a trial involving 940 male participants, examining flare occurrences and various predictors such as treatment type and serum urate levels.
- The findings indicated that the risk of gout flares was similar for both medications when using effective treatment strategies, with notable predictors of flare being younger age, higher initial urate levels, and the absence of tophi.
Rationale & Objective: We conducted a prespecified examination of the efficacy and safety of allopurinol and febuxostat administered using a treat-to-target strategy in trial participants with chronic kidney disease (CKD).
Study Design: Prespecified subcohort analysis of a randomized controlled trial.
Setting & Participants: A substudy of the STOP Gout Trial in participants with CKD.
Objective: Individuals with chronic pain due to knee osteoarthritis (OA) are insufficiently physically active, and alterations of facilitatory and inhibitory nociceptive signaling are common in this population. Our objective was to examine the association of these alterations in nociceptive signaling with objective accelerometer-based measures of physical activity in a large observational cohort.
Design: We used data from the Multicenter Osteoarthritis Study.
Objective: Hand osteoarthritis (OA) pain is characterized as heterogeneous and multifactorial. Differences in pain may be explained by underlying phenotypes, which have not been previously explored DESIGN: Latent class analysis determined classes of participants with hand OA from the Nor-Hand study baseline examination (2016-17) based on a biopsychosocial framework. Outcomes were hand and overall bodily pain intensity (Numeric Rating Scale, 0-10) at baseline and follow-up (2019-21), The relations of the classes to pain outcomes at baseline, follow-up, and change over time were analysed in separate models by linear regression, using the overall healthiest class as reference.
View Article and Find Full Text PDFObjective: Intra-articular (IA) mineralization may contribute to osteoarthritis (OA) structural progression. We studied the association of IA mineralization on knee computed tomography (CT) with cartilage damage worsening on knee magnetic resonance imaging (MRI), with a focus on location- and tissue-specific effects.
Methods: Participants from the Multicenter Osteoarthritis Study with knee CT and MRI scans were included.
Objective: Using trial data comparing treat-to-target allopurinol and febuxostat in gout, we examined participant characteristics associated with serum urate (SU) goal achievement.
Methods: Participants with gout and SU ≥6.8 mg/dL were randomized to allopurinol or febuxostat, titrated during weeks 0 to 24, and maintained weeks 25 to 48.
Background: People with knee osteoarthritis walk with excessive muscle co-contraction that can accelerate disease progression. Central pain sensitization is common in people with knee osteoarthritis and may be related to walking patterns. The objective of this study was to examine the relation of central pain sensitization with muscle co-contraction during walking in people with knee osteoarthritis.
View Article and Find Full Text PDFObjective: One of the less understood adverse effects while taking opioids is the paradoxical increase in pain, known as opioid-induced hyperalgesia (OIH). We sought to determine whether pain sensitization mediates the relation of taking an opioid to pain severity in people with knee osteoarthritis (OA).
Methods: We included participants in a National Institutes of Health-funded cohort study of people with or at risk of knee OA.
Objective: To quantify the effect of corticosteroids compared to lidocaine-only injections over 12 weeks among patients with knee osteoarthritis (KOA).
Methods: Participants with KOA were randomized to receive a knee injection of methylprednisolone acetate 1 mL (40 mg) plus 2 mL lidocaine (1%) or 1 mL saline and 2 mL lidocaine. Participants and providers were blinded to treatment allocation using an opacified syringe.
Objective: To determine i) pain phenotypes (PP) in people with early-stage knee osteoarthritis (EKOA); ii) the longitudinal association between the phenotypes and pain worsening at two years.
Design: We studied participants with EKOA from the Multicenter Osteoarthritis Study defined as pain intensity ≤3/10, Kellgren and Lawrence grade ≤2, intermittent pain none to sometimes, and no constant pain. Two models of PP were explored.
Placebo effects in osteoarthritis: implications for treatment and drug development.
Nat Rev Rheumatol
October 2023
Osteoarthritis (OA) is the most common form of arthritis worldwide, affecting ~500 million people, yet there are no effective treatments to halt its progression. Without any structure-modifying agents, management of OA focuses on ameliorating pain and improving function. Treatment approaches typically have modest efficacy, and many patients have contraindications to recommended pharmacological treatments.
View Article and Find Full Text PDFObjective: Conservative pain management strategies for knee osteoarthritis (KOA) have limited effectiveness and do not employ a pain-mechanism informed approach. Pain Informed Movement is a novel intervention combining mind-body techniques with neuromuscular exercise and pain neuroscience education (PNE), aimed at improving endogenous pain modulation. While the feasibility and acceptability of this program has been previously established, it now requires further evaluation in comparison to standard KOA care.
View Article and Find Full Text PDFArticle Synopsis
- Calcium pyrophosphate deposition (CPPD) disease is common but previously lacked validated classification criteria, which have now been developed by the American College of Rheumatology (ACR) and EULAR.
- A multinational group established these criteria by generating lists of candidate items, refining definitions, and validating the framework through patient profiles and statistical analysis.
- The new criteria allow for CPPD classification based on specific symptoms, testing results, and a scoring system, demonstrating high sensitivity and specificity in identifying the disease.
Objective: To examine whether pain sensitization is associated with hand and lower extremity function in people with hand osteoarthritis (OA) in the Nor-Hand study.
Design: Pain sensitization was assessed by pressure pain thresholds (PPTs) and temporal summation (TS). Hand function was assessed by Australian/Canadian Osteoarthritis Hand Index (AUSCAN) (range: 0-36), grip strength and Moberg pick-up test, and lower extremity function was assessed by Western Ontario and McMaster Universities Osteoarthritis Index (range: 0-68), 30-s chair stand test, and 40-m walk test.
Article Synopsis
- Calcium pyrophosphate deposition (CPPD) disease lacks established classification criteria, prompting the American College of Rheumatology (ACR) and EULAR to create the first validated criteria for symptomatic cases.
- A multinational team developed these criteria by analyzing patient profiles, defining candidate items, and employing decision-making methods to establish a scoring system for classification.
- The new criteria showed high sensitivity (92.2% in one cohort; 99.2% in another) and specificity (87.9% and 92.5%, respectively), making them effective tools for diagnosing CPPD disease and advancing research.