Publications by authors named "Tugumichi Koshinaga"
Background/aims: To clarify the neurological function with respect to external anal sphincter (EAS) muscles in child patients with or without soiling after ileal J pouch anal anastomosis (IPAA), we examined the terminal motor latency in the pudendal motor nerves (PNTML).
Methodology: A total of nine patients after IPAA for UC (7 cases) and AC (2 cases) were studied (6 males and 3 females, 10 to 15 with a mean age of 13.8 years).
Background/aims: To clarify the functional differences of the enteric nervous system in the human internal anal sphincter (IAS) between the proximal and distal parts from the dentate line, we investigated the enteric nerve responses of normal proximal and distal IAS in vitro.
Methodology: Normal IAS specimens derived from 20 patients with lower rectal cancer (14 men and 6 women aged from 48 to 77 years, average 66.5 years) were used.
Background/aims: The structure of the pyloric sphincter (PS) muscle has recently been shown to divide into two parts (proximal and distal parts). To clarify the functional differences in the human PS between proximal and distal parts, we investigated the enteric nerve responses in normal proximal and distal PS specimens.
Methodology: Normal PS specimens derived from 20 patients with early gastric cancer (13 men and 7 women aged from 50 to 64 years, average 58.
Background/aims: There are no reports about the relationship between soiling and other defecation states in patients with ulcerative colitis (UC) after ileal J pouch-anal anastomosis (IPAA). To assess the defecation states in patients with or without soiling at 5 years or more after IPAA for UC, we studied clinical findings in such patients.
Methodology: Subjects with UC who had undergone IPAA [a 5-cm short cuff, anal canal mucosa including anal transitional zone (AZT) stripped from the level of dentate line (DL)] with ileostomy closure at least 60 to 132 months (mean; 103.
Background: We investigated the relationship between interdigestive migrating motor complex, phase III (IMMC-pIII) and postoperative quality of life (QOL) in pylorus-preserving gastrectomy (PPG) patients.
Materials And Methods: A total of 40 patients (26 men and 14 women; average age 59.4 years) 5 to 7.
Background: Vagal nerve-preserving distal gastrectomy reconstructed by interposition of a jejunal J pouch with a jejunal conduit (hereinafter called DGP) is a function-preserving operation for early gastric cancer. However, some patients after DGP have suffered from postprandial stasis in the substitute stomach, and postprandial stasis leads to abdominal symptoms. To clarify the significance of mosapride citrate (MS) for prevention of food stasis in the substitute stomach for patients after DGP, we studied the effects of MS before and after administration of MS.
View Article and Find Full Text PDFBackground/aims: The possibility that interleukin-1 beta (IL-1beta) is a neuromodulator of the non-adrenergic non-cholinergic (NANC) inhibitory nerves which may be mediated by nitric oxide (NO) was recently reported from animal experiments. To clarify the physiological significance of the relationship between IL-1beta and NO in the normal human colon, enteric nervous responses to IL-1beta in the normal colon muscle strips were investigated.
Methodology: Normal colon muscle strips derived from patients who underwent colon resection for left-sided colon cancers (14 cases) were used.
Background: It is established that substance P (SP) is released by stimulation of nonadrenergic noncholinergic (NANC) excitatory nerves and vasoactive intestinal peptide (VIP) by stimulation of NANC inhibitory nerves. To evaluate the function of peptidergic nerves such as SP and VIP in small-bowel isografts, we examined the enteric nerve responses to SP and VIP in the isografted rat jejunum, using the normal rat jejunum as a control.
Methods: Orthotopic entire small bowel transplantation (SBT) with portocaval drainage was performed from Lewis rats to Lewis rats.