Publications by authors named "Tugce Ipek"
The cardiotoxicity risk of hydroxychloroquine (HCQ) and azithromycin (AZM) has been the subject of intensive research triggered by safety concerns in COVID-19 patients. HCQ and AZM have been associated with QT interval prolongation and drug-induced arrhythmias, however other cardiotoxicity mechanisms remain largely unexplored. Our group has pioneered the living heart slice preparation, an platform that maintains native cardiac tissue architecture and physiological electrical and contractile properties.
View Article and Find Full Text PDFPurpose: To evaluate demographic and lifestyle factors associated with aqueous deficient and evaporative dry eye disease.
Methods: A total of 1125 general public visitors (707 females, mean ± SD age, 33 ± 21, range 5-90 years) at the Royal Society Summer Science Exhibition were recruited in a cross-sectional study. A demographic and lifestyle factor questionnaire was administered, and dry eye symptomology (DEQ-5 score), ocular surface characteristics (conjunctival hyperaemia, and infrared meibography), and tear film parameters (tear meniscus height, non-invasive breakup time, and lipid layer grade) were evaluated for the left eye of each participant within a single session.
Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon's Capsule + Conjunctival Model.
Invest Ophthalmol Vis Sci
February 2019
Purpose: Surgical techniques such as trabeculectomy aim to treat glaucoma by making an incision into the scleral tissue, to create an alternative drainage pathway for aqueous to flow into the sub-Tenon's/subconjunctival space. However, tissue fibrosis and wound healing occurring after the procedures can reduce the success rate. This study aims to investigate the synergistic effects of aqueous humor in combination with shear stress on the fibrosis response occurring in Tenon's capsule and conjunctival tissue (TCCT) after glaucoma surgery.
View Article and Find Full Text PDFArticle Synopsis
- Cataract surgery can worsen dry eye symptoms, possibly due to factors like surgical light exposure and tissue disruption.
- An in vitro experiment showed that light from a halogen bulb delayed wound healing in conjunctival fibroblasts and reduced their viability by 20% after exposure.
- The findings indicate that light exposure during surgery may contribute to post-operative dry eye, suggesting the need for more research on its effects on various ocular cells.