From to : xenotransplantation and vascularization of mouse embryonic kidneys in a microfluidic chip.

Organoids are emerging as a powerful tool to investigate complex biological structures . Vascularization of organoids is crucial to recapitulate the morphology and function of the represented human organ, especially in the case of the kidney, whose primary function of blood filtration is closely associated with blood circulation. Current microfluidic approaches have only provided initial vascularization of kidney organoids, whereas transplantation to animal models is problematic due to ethical problems, with the exception of xenotransplantation onto a chicken chorioallantoic membrane (CAM).