Publications by authors named "Tugba Atci"
Background: Studies comparing the clinical and prognostic differences between pediatric- and adult-onset mycosis fungoides (MF) are limited.
Objectives: To determine the impact of childhood-onset MF on clinical features and disease course in a large series.
Methods: Consecutive MF patients seen in a single centre between 2007 and 2021 were categorized into 3 groups: (i) MF patients diagnosed in the pediatric ages (≤18 years) (pediatric group), (ii) MF patients with disease onset in the pediatric period and diagnosis in adulthood (lately diagnosed pediatric-onset group), and (iii) MF patients with disease onset in the adulthood period (>18 years) (adult-onset group).
Background: Linear IgA bullous dermatosis (LABD) is an uncommon disease with only a few reported studies in large series with long follow-up periods.
Objectives: To evaluate the clinical presentation, immunopathological features, management, and disease course in LABD patients.
Methods: Data including demographics, clinical features, histopathological and immunofluorescence findings of LABD patients, in addition to the preferred treatments and responses to treatments were evaluated.
Introduction: The natural history, the progression of a disease process in an individual over time, has not yet been fully elucidated in hidradenitis suppurativa (HS). In this large multicenter study, we aimed to investigate the natural history of HS and its gender differences.
Methods: This cross sectional study included 827 patients.
A Rare Coexistence of Turner Syndrome and Mycosis Fungoides: A Case Report.
J Clin Res Pediatr Endocrinol
October 2024
Article Synopsis
- Turner syndrome (TS) is the most common sex chromosome abnormality in females, leading to symptoms like short stature and increased risk of certain cancers, including mycosis fungoides (MF).
- A case study describes an 11-year-old girl with TS who developed itchy skin lesions diagnosed as CD4+ MF after receiving growth hormone therapy.
- This case highlights the rare occurrence of MF in pediatric TS patients, suggesting a potential link between TS and MF, and the need for careful skin evaluations in those with TS.
Article Synopsis
- The study examined 30 patients diagnosed with Gorlin syndrome over 23 years, focusing on skin and other findings associated with the condition.
- Key findings included that basal cell carcinoma (BCC) was present in 90% of patients, with a significant occurrence of odontogenic keratocysts (OKCs) and palmoplantar pitting, particularly in children.
- The research highlights the importance of identifying specific skin lesions, like papular BCCs and acral epidermoid cysts, to improve early diagnosis of Gorlin syndrome in younger patients.
Background: Tumors indicating the advanced stage of mycosis fungoides (MF) have a rich clinical spectrum. Although it is known that the prognosis of MF generally worsens following the development of tumors, some cases may have a relatively indolent course, and the role of clinical characteristics regarding prognosis has still not been well understood.
Methods: MF patients were retrospectively evaluated regarding the development of tumors.
Evaluation of secondary malignancies in a large series of mycosis fungoides.
An Bras Dermatol
April 2024
Article Synopsis
- Mycosis Fungoides (MF) patients may have an increased risk of developing Secondary Malignancies (SMs), but the specific relationship and risk factors are not well defined.
- In a study of 730 MF patients over an average of nearly 68 months, 56 cases of SMs were found in 7.1% of patients, with a notable prevalence of hematologic malignancies.
- The majority of SM cases occurred in early-stage and classical-type MF patients, and systemic hematological malignancies, including lymphomatoid papulosis, were common, highlighting the need for ongoing monitoring in this patient group.
Eyelid involvement of primary cutaneous lymphomas: A clinical perspective.
Australas J Dermatol
November 2023
Article Synopsis
- Eyelids can be involved in various types of lymphomas, including systemic, ocular adnexal, and primary cutaneous lymphomas (PCLs), with their frequency of involvement still unclear.
- Primary cutaneous T-cell lymphomas, particularly mycosis fungoides (MF), are more common than B-cell lymphomas overall, but B-cell lymphomas are more frequently found specifically on the eyelids.
- The clinical features of MF on the eyelids can resemble other skin conditions, and their diverse presentation is important for early diagnosis, as eyelid involvement may indicate a worse prognosis.
Background: Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are subtypes of pemphigus with distinct clinical and laboratory features. The transition between these two subtypes has rarely been reported previously.
Methods: The data of PV patients who exhibited clinical and immunoserological transition to PF during the follow-up period were retrospectively evaluated regarding their demographical, clinical, and laboratory characteristics.
A case of nail sarcoidosis with rich clinical findings.
Sarcoidosis Vasc Diffuse Lung Dis
September 2022
Is the Frequency of Seborrheic Dermatitis Related to Climate Parameters?
Sisli Etfal Hastan Tip Bul
March 2022
Objectives: The aim of this study was to determine the frequency of seborrheic dermatitis (SD) by months and seasons in Istanbul, Turkey, and to examine the relationships between SD frequency and meteorological data, such as average temperature (°C), average humidity (%), average sunshine duration, and solar radiation per months.
Methods: The study was conducted at Dermatology Department of Haseki Training and Research Hospital. The data of all adult patients who applied to the dermatology outpatient clinic between June 2018 and May 2020 were obtained.
Background: Xeroderma pigmentosum (XP) is a rare genodermatosis with a lifelong propensity to develop malignant skin tumors.
Methods: In this retrospective study, 24 XP patients were evaluated with regard to frequency and clinicopathological features of benign and malignant skin tumors.
Results: Seventeen patients had at least one malignant skin tumor diagnosed: basal cell carcinoma (BCC) in 13 patients (n = 72), basosquamous carcinoma in three patients (n = 4), squamous cell carcinoma in six patients (n = 13), keratoacanthoma in three patients (n = 15), and melanoma in six patients (n = 18).
Efficacy of narrow-band ultraviolet-B therapy in patch-stage mycosis fungoides: A clinical study and review of the literature.
Photodermatol Photoimmunol Photomed
July 2020
Background/purpose: We investigated the efficacy of narrow-band UVB in patch-stage MF and reviewed the literature to re-evaluate the role of this phototherapy method in early MF.
Methods: Early-stage MF patients treated with narrow-band UVB were included. Number of narrow-band UVB treatment sessions, treatment duration, cumulative UV dose, clinical response results, side effects, duration of the remission period and relapse rate were evaluated.
Background: The frequency of clinicoepidemiological variants of Kaposi's sarcoma (KS) differs markedly throughout the world. The iatrogenic variant is mainly associated with the use of immunosuppressive therapy.
Aims: We aimed to investigate the distribution of KS variants in our practice and elucidate the underlying causes of iatrogenic KS.
Article Synopsis
- Follicular mycosis fungoides (FMF) is a rare type of skin cancer characterized by various clinical symptoms, including typical follicular lesions and other atypical manifestations.
- A study analyzed 27 FMF patients from a larger registry, focusing on their demographics, clinical features, treatments, and outcomes.
- The findings revealed additional symptoms like Lichen spinulosus-like lesions and unusual facial plaques, highlighting the importance of recognizing overlooked symptoms to improve early diagnosis of this aggressive condition.
Article Synopsis
- - The study focused on folliculotropic mycosis fungoides (FMF), a rare variant of skin lymphoma, examining 27 patients to uncover less-known skin symptoms associated with the condition.
- - Researchers identified unusual dermatological signs in FMF patients, such as lichen-like lesions, facial plaques resembling lupus, and other atypical skin changes, which are often overlooked.
- - Recognizing these uncommon manifestations could improve early diagnosis and treatment for patients with this aggressive form of mycosis fungoides.