Tigilanol Tiglate-Induced Changes in Secretome Profiles Alter C-Met Phosphorylation and Cell Surface Protein Expression in H357 Head and Neck Cancer Cells.

Tigilanol tiglate (TT, also known as EBC-46) is a novel, plant-derived diterpene ester possessing anticancer and wound-healing properties. Here, we show that TT-evoked PKC-dependent S phosphorylation of the tyrosine kinase MET leads to subsequent degradation of tyrosine phosphorylated p-Y and p-Y MET species. PKC inhibition with BIM-1 blocked S phosphorylation of MET and led to MET cell surface accumulation.