A Systematic Review on Safety and Efficacy of Ayurvedic Interventions in Hemiplegia ().

The study's objective is to conduct a comprehensive systematic review for assessing the safety and efficacy of Ayurvedic interventions in managing hemiplegia/Pakshaghata. The study involved a search across multiple online databases and online clinical trial registries. Additionally, major Ayurveda postgraduate institutes were contacted to acquire unpublished trial data related to hemiplegia/Pakshaghata.

Interactions between lncRNAs and cyclins/CDKs complexes; key players in determining cancer cell response to CDKs inhibitors.

Transcription takes place over a significant portion of the human genome. However, only a small portion of the transcriptome, roughly 1.2%, consists of RNAs translated into proteins; the majority of transcripts, on the other hand, comprise a variety of RNA families with varying sizes and functions.

Epidermal Growth Factor Receptors Unveiled: A Comprehensive Survey on Mutations, Clinical Insights of Global Inhibitors, and Emergence of Heterocyclic Derivatives as EGFR Inhibitors.

Mutations that overexpress the epidermal growth factor receptor (EGFR) are linked to cancers like breast (15-20%), head and neck (10-15%), colorectal (5-8%), and non-small cell lung cancer (10-50%), especially in East Asian populations. EGFR activation stimulates "RAS/RAF/MEK/ERK, PI3K/Akt, and MAPK" pathways, which enhance cell division, survival, angiogenesis, and tumor growth while inhibiting apoptosis and metastasis. Secondary mutations (e.

Equine piroplasmosis in different geographical areas in France: Prevalence heterogeneity of asymptomatic carriers and low genetic diversity of Theileria equi and Babesia caballi.

Equine piroplasmosis is a worldwide tick-borne disease caused by the parasites Theileria equi sensu lato and Babesia caballi, with significant economic and sanitary consequences. These two parasites are genetically variable, with a potential impact on diagnostic accuracy. Our study aimed to evaluate the frequency of asymptomatic carriers of these parasites in France and describe the circulating genotypes.

How critical is SME financial literacy and digital financial access for financial and economic development in the expanded BRICS block?

Introduction: The expanded BRICS block presents significant opportunities for SMEs (Small and Medium Enterprises), but challenges related to financial literacy and digital access hinder their potential. While global efforts emphasize financial literacy and digitization as key drivers of economic growth, especially in developing regions, their specific impact on SMEs in the BRICS block remains underexplored. This paper contributes to the literature by contextualizing how financial literacy and digital financial access influence SME sustainability and economic progress, particularly in light of ongoing efforts to bridge the digital divide.

The Future Hospital in Global Health Systems: The Future Hospital as an Entity.

Health care is changing rapidly. Hospitals are, and will remain, an essential setting to deliver it. We discuss how to maximise the benefits of hospitals in the future in different geographic and health system settings, highlighting a series of cross-cutting issues.

Synergistic design of CuO/CoFe₂O₄/MWCNTs ternary nanocomposite for enhanced photocatalytic degradation of tetracycline under visible light.

This study involves a novel CuO/CoFe₂O₄/MWCNTs (CCT) nanocomposite, developed by integrating cobalt ferrite (CoFe₂O₄) and copper oxide (CuO) nanoparticles onto multi-walled carbon nanotubes (MWCNTs), for the degradation of tetracycline (TC) under visible light. The photocatalyst was extensively characterized using XRD, HR-SEM, EDX, HR-TEM, UV-Vis, BET, and PL analysis. The synthesized CoFe₂O₄ and CuO nanoparticles exhibited crystallite sizes of 46.

Global burden of cancer pattern in 2020 & prediction to 2040 among older adults.

Background & objectives Cancer is one of the leading causes of death among older adults worldwide. The global burden of cancer among older individuals is increasing due to the ageing population. The increasing burden of cancer among older adults will pose significant social and economic challenges for the delivery of healthcare services.

Correlation of Two-Minute and Six-Minute Walk Tests With Spirometric Indices in Patients With Severe Chronic Obstructive Pulmonary Disease at a Selected Tertiary Care Hospital in Puducherry.

Background Chronic obstructive pulmonary disease (COPD) is a progressive respiratory condition characterised by airflow limitation and reduced exercise capacity. The Six-Minute Walk Test (6MWT) and Two-Minute Walk Test (2MWT) are commonly used to assess functional exercise capacity in COPD patients. This study aims to evaluate the correlation between the distance covered in the 2MWT and 6MWT with spirometric indices (such as Forced Expiratory Volume in 1 second (FEV₁), Forced Vital Capacity (FVC), and FEV₁/FVC) in COPD patients.

Exploration of the Reasons for Poor Adherence Among Metabolic Syndrome Patients Attending a Tertiary Care Hospital in Tamil Nadu, India: A Mixed Method Study.

Background A major challenge in the treatment of MetS is the prevalence of low rates of adherence to the treatment regimen for individual components by the affected persons. This study aimed to estimate the medication adherence level among those with metabolic syndrome, determine the factors significantly associated with low adherence to medication, and explore the reasons for poor adherence to medication Materials and methods This sequential explanatory type of mixed method study was conducted among the metabolic syndrome patients attending the lifestyle clinic of a tertiary care hospital in the Salem district of Tamil Nadu, India. For the quantitative component, 210 was the sample size and for the qualitative component, the sample size was six.

Predictors of Mortality for Upper Extremity Penetrating Vascular Injuries (UEPVI).

Objectives: Our objective was to determine risk factors and operative outcomes for patients with upper extremity penetrating vascular injuries(UEPVI).

Methods: A retrospective review was performed of all adult UEPVI patients presenting to a level I trauma center between 1986 and 2019. Statistical analyses were performed to determine the independent predictors of mortality and hospital length of stay(LOS) among patients who underwent operative repair.

Endocrown: A Minimally Invasive Alternative to Conventional Fixed Prosthesis.

Endodontically treated teeth with compromised coronal tooth structure often require core build-ups with the support of radicular posts. In certain cases, the traditional post and core approach may not be possible due to various anatomical and clinical contraindications. Such cases require more meticulous planning and alternative treatment approaches for successful outcomes.

Differential gene expression profile in treated human gingival keratinocytes and their role in the development of HNSCC.

Background: Periodontitis is considered to be one of the major risk factors associated with cancers of the oral cavity. Periodontogenic pathogens such as and are the important pathogens associated with periodontitis. Chronic exposure to bacterial components induces changes in the nearby cells.

Development and Validation of a Yoga-Based Intervention for Speech Dysfunction and Speech Difficulties Among Patients With Parkinson's Disease.

Introduction Parkinson's disease (PD) is primarily thought to be brought on by the death of dopaminergic neurons in the substantia nigra pars compacta of the basal ganglia. Communication difficulties are a common symptom of PD, affecting both motor speech and language systems. These challenges significantly impact the quality of life by reducing participation in communication, leading to social withdrawal, and increasing the risk of social isolation and stigma among individuals with PD.

A Successful Conservative Management of Twin Gestation of Complete Molar Gestation and Co-Existing Normal Fetus: A Case Report.

Twin pregnancies consisting of one normal fetus and one complete mole are very rare. The main concerning risks associated with the continuation of such pregnancy are hyperthyroidism, theca lutein cysts, preeclampsia, and the development of GTD (gestational trophoblastic disease) spectrum (neoplasia) in the mother, which is due to high human chorionic gonadotropin (HCG) values, and intrauterine death and prematurity in the coexistent normal fetus. We report the successful outcome of conservative management in a healthy mother and baby.

A comprehensive review on early detection of drusen patterns in age-related macular degeneration using deep learning models.

Age-related Macular Degeneration (AMD) is a leading cause of visual impairment and blindness that affects the eye from the age of fifty-five and older. It impacts on the retina, the light-sensitive layer of the eye. In early AMD, yellowish deposits called drusen, form under the retina, which could result in distortion and gradual blurring of vision.

Assessment of Self-Medication Practices and Knowledge Among Medical Students in Chengalpattu District: A Cross-Sectional Study.

Introduction: The practice of self-medication is wherein individuals initiate the use of medications without consulting a healthcare professional. College life is a period marked by academic, social, and personal changes. Due to their greater freedom and the pressure of academic success, students face various health issues.

Impact of cartoon-animated video, caregiver-supervised training, and pamphlet on plaque control, oral hygiene status, and oral hygiene knowledge, attitude, and practices in orphaned adolescents: A randomized controlled trial.

Aim: To evaluate the effectiveness of cartoon animated video, caregiver-supervised training, and pamphlet-based oral health education on plaque control, oral hygiene status, and oral health knowledge, attitude, and practice (KAP) among orphaned adolescents with plaque-induced gingivitis.

Methods: A total of ninety adolescents were randomly selected and allocated into three different groups. Group A received the pamphlet (n = 30), Group B received the cartoon animated video (n = 30), and Group C received the caregiver-supervised training (n = 30).

Impact of maternal thyroid dysfunction on fetal and maternal outcomes in pregnancy: a prospective cohort study.

Background: Thyroid dysfunction in pregnancy can adversely impact maternal and fetal outcomes. However, the association between thyroid status and specific adverse outcomes needs clarity, especially in understudied regions.

Objective: This prospective cohort study aimed to illuminate the multifaceted associations between maternal thyroid dysfunction and feto-maternal outcomes in Gujarat, India.

Analysis of systemic serum vancomycin levels following intraarticular application in primary total joint arthroplasty.

Introduction: Periprosthetic joint infection (PJI) is a serious complication following primary total joint arthroplasty (TJA). PJI accounts for 15-25% of revision surgeries, therefore it is associated with PJI is associated with substantial patient morbidity and mortality as well as increased healthcare expenditures due to complex treatment strategies. Recently, intraoperative local application of vancomycin powder is increasingly being used in primary total hip and knee arthroplasty (THA, TKA) as an additive strategy for PJI prevention.

Emerging Biomarkers for Assessing Thrombotic Risk in Patients Receiving Direct Oral Anticoagulants (DOACs).

Direct Oral Anticoagulants (DOACs) have transformed the management of thrombotic disorders, offering a more convenient and effective alternative to traditional vitamin K antagonists (VKAs). However, assessing thrombotic risk in patients treated with DOACS remains crucial due to the potential for recurrent events. Current clinical risk scores have limitations in predicting and monitoring venous thromboembolism (VTE) risk in specific DOAC populations.

Enhancing diabetic retinopathy and macular edema detection through multi scale feature fusion using deep learning model.

Background: This work tackles the growing problem of early identification of diabetic retinopathy and diabetic macular edema. The deep neural network design utilizes multi-scale feature fusion to improve automated diagnostic accuracy. Methods This approach uses convolutional neural networks (CNN) and is designed to combine higher-level semantic inputs with low-level textural characteristics.

A Rare Case of Non-ossifying Fibroma Causing Pathological Subtrochanteric Femur Fracture in a Child: A Common Lesion at an Uncommon Location.

Non-ossifying fibroma (NOF) is a benign expansive lytic lesion more frequently found in children and adolescents at the metaphysis of long bones in and around the knee joint, typically resolving spontaneously or by ossification. This report presents a rare case of an 11-year-old child with a pathological subtrochanteric femur fracture attributed to an underlying NOF. We describe the diagnosis and surgical management of curettage and internal fixation using a proximal humerus locking plate, resulting in complete resorption of the lytic zone and an excellent clinical outcome.