[Monitoring the chronic myeloid leukemia patients between 2008 and 2018; the experience of the Hematology and Bone Marrow Transplantation Unit Târgu-Mureș].

Introduction And Aim: Chronic myeloid leukemia is a clonal myeloproliferative disorder characterized by the BCR-ABL gene rearrangement with translocation between chromosomes 9 and 22. The constitutively active BCR-ABL tyrosine kinase inhibitor became the standard frontline therapy. The molecular monitoring is essential.

Real-time quantitative PCR detection of WT1 and M-BCR-ABL expressions in chronic myeloid leukemia.

Unlabelled: The Philadelphia chromosome and the resulting BCR-ABL fusion gene represent the hallmark event in chronic myeloid leukemia (CML) and their discoveries radically changed the management of these patients. Currently Wilms tumor 1 gene (WT1) is intensively investigated as high WT1 expression levels have been demonstrated in case of multiple solid tumors and malignant hematological syndromes (acute myeloid and lymphoid leukemia, myelodysplastic syndromes and chronic myeloid leukemia). The aim of our study was to investigate the WT1 expression in CML patients and its possible contribution to disease evolution.

Histopathological, immunophenotypic and clinical particularities and evolution of a case of hepatosplenic T-cell lymphoma in transformation to leukemia.

We present the possibilities of diagnosis correlating the pathological, immunophenotyping and clinical aspects of a rare case of T-cell lymphoma in a 23-year-old patient with leukemic transformation. In our consideration, it is very important to describe this case because in the literature there are very few cases presented and the treatment of this type of lymphoma does not present optimal results, the evolution of the patients being from three months to two years. The treatment modality that gives the possibility to prolong survival and cure is hematopoietic stem cell transplantation.

Monitoring M-BCR-ABL expression level in CML patients by RQ-PCR: experience of a single Center.

Unlabelled: Chronic myelogenous leukemia (CML) is characterized by the Philadelphia chromosome and the BCR-ABL fusion gene that encodes an abnormal tyrosine kinase. Development of specific tyrosine kinase inhibitors completely changed the management of these patients.

Materials And Methods: Between April 2008 and July 2012, at the Molecular Biology Laboratory, University of Medicine and Pharmacy of Targu Mures, Romania, we monitored the M-BCR-ABL transcript level by real time quantitative PCR in case of 15 CML patients diagnosed at the Hematology and Transplant Center of Targu Mures.

A versatile solvent-free mechanochemical route to the synthesis of heterometallic dicyanoaurate-based coordination polymers.

The solid-state mechanochemical method was proved to be a fast, simple, and efficient route to the synthesis of heterometallic [Au(CN)(2)]-based coordination polymers. Thus, a series of mixed-metal complexes, such as KCo[Au(CN)(2)](3), KNi[Au(CN)(2)](3), Cu(H(2)O)(2)[Au(CN)(2)](2), and Zn[Au(CN)(2)](2), was obtained by grinding stoichiometric amounts of K[Au(CN)(2)] and transition metal(II) chlorides. This solid-state method rapidly yields pure dicyanoaurate-based compounds, also in cases when the aqueous solution synthesis leads to an unseparable mixture of products.

Guest escape and uptake in nonporous crystals of a gold(I) macrocycle.

The nonporous gold(I) diphosphine complex [Au(2)(cis-dppe)(2)](NO(3))(2) [1, cis-dppe = cis-1,2-bis(diphenylphosphino)ethylene] is robust enough to trap guests, but at the same time, it is flexible enough to allow guest release without destruction of its crystal lattice. This nonporous gold(I) compound 1 is also efficient at capturing and releasing carbon dioxide in a controlled manner.

[mu-4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene]bis[(trifluoroacetato)gold(I)] and its dichloromethane 0.58-solvate.

The dinuclear Au(I) complex containing the 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (xantphos) ligand and trifluoroacetate anions exists in a solvent-free form, [mu-4,5-bis(diphenylphosphino)-9,9-dimethylxanthene]bis[(trifluoroacetato)gold(I)], [Au(2)(C(2)F(3)O(2))(2)(C(39)H(32)OP(2))], (I), and as a dichloromethane solvate, [Au(2)(C(2)F(3)O(2))(2)(C(39)H(32)OP(2))].0.58CH(2)Cl(2), (II).

Synthesis and structure of a cyanoaurate-based organotin polymer exhibiting unusual ion-exchange properties.

We synthesized and structurally characterized the first cyanoaurate-based organotin polymer Me(3)Sn[Au(CN)(2)] (1), which exhibits unusual ion-exchange properties. In the structure of 1, the void space of the 2D grids formed via Au..

Solvent-assisted spontaneous resolution of a 16-membered ring containing gold(I) showing short Au...Au aurophilic interaction and a figure-eight conformation.

The achiral 4,6-bis(diphenylphosphino) phenoxazine (nixantphos) ligand was used to synthesize a gold(I) complex, [Au2(nixantphos)2](NO3)2, containing a 16-membered [Au2(nixantphos)2](+2) cationic ring in a chiral figure-eight conformation. The single crystal X-ray diffraction analysis of [Au2(nixantphos)2](NO3)2.3MeOH.