Preliminaries to artificial consciousness: A multidimensional heuristic approach.

The pursuit of artificial consciousness requires conceptual clarity to navigate its theoretical and empirical challenges. This paper introduces a composite, multilevel, and multidimensional model of consciousness as a heuristic framework to guide research in this field. Consciousness is treated as a complex phenomenon, with distinct constituents and dimensions that can be operationalized for study and for evaluating their replication.

Iron Deficiency Anemia in Children During and After PICU Stay: Single-Center Retrospective Cohort, 2021-2022.

Objectives: The primary objective was to determine iron deficiency (ID) anemia (IDA) monitoring practices in children during PICU stay. A secondary objective was to determine the current follow-up practices for IDA after PICU discharge.

Design: Retrospective observational study of 2 years (2021-2022).

Take Charge of Your Professional Network of Colleagues to Succeed in Academic Medicine.

Instead of relying on a single, dyadic mentor for career advice, we suggest creating and intentionally cultivating a professional network of colleagues (PNC) to guide your academic career. There are four archetypes to help clinician educators succeed in academic medicine: a traditional mentor, a sponsor, a coach, and a connector.1 However, these roles are not discrete, and overlap occurs.

Classification of Plant-Based Drinks Based on Volatile Compounds.

The increasing popularity of plant-based drinks has led to an expanded consumer market. However, available quality control technologies for plant-based drinks are time-consuming and expensive. Two alternative quality control methods, gas chromatography with ion mobility spectrometry (GC-IMS) and an electronic nose, were used to assess 111 plant-based drink samples.

Sequence analysis of the 5' region of the chymotrypsin C (CTRC) gene in chronic pancreatitis.

Background/objectives: Loss-of-function chymotrypsin C (CTRC) variants increase the risk for chronic pancreatitis (CP) by reducing protective pancreatic CTRC activity. Variants in the 5' upstream region that includes the promoter might affect CTRC expression but have not been investigated to date. The aim of the present study was to address this knowledge gap.

Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer.

Tertiary lymphoid structures (TLS) are organized immune cell aggregates that arise in chronic inflammatory conditions. In cancer, TLS are associated with better prognosis and enhanced response to immunotherapy, making these structures attractive therapeutic targets. However, the mechanisms regulating TLS formation and maintenance in cancer are incompletely understood.

A case series of patients with β-thalassemia trait and iron overload: from multifactorial hepcidin suppression to treatment with mini-phlebotomies.

Not available.

Early Oral Feeding in Patients Undergoing Upper Gastrointestinal Surgery: A Propensity Score-matching Study.

Background/aim: Enhanced recovery after surgery (ERAS) protocol is adopted in clinical practice worldwide, but a lack of evidence for measurable benefits after upper gastrointestinal (GI) surgeries can be detected especially regarding early oral feeding.

Patients And Methods: A propensity score-matching study was conducted at the Department of Surgery of the University of Pécs between January 2020 and December 2023. The study included patients who underwent upper GI cancer surgery and were treated according to an early oral feeding protocol (EOF).

Carboxyl ester lipase hybrid 1 (CEL-HYB1) haplotypes confer varying risk for chronic pancreatitis.

The CEL-HYB1 hybrid allele of the carboxyl ester lipase (CEL) gene and its pseudogene (CELP) has been associated with chronic pancreatitis (CP). Recent work indicated that amino acid positions 488 and 548 in CEL-HYB1 determined pathogenicity. Haplotype Thr488-Ile548 was associated with CP while haplotypes Thr488-Thr548 and Ile488-Thr548 were benign.

High-Performance Fluorine-Lean Thin Aromatic Hydrocarbon Membranes Based on Polyvinylidene Fluoride for Hydrogen Fuel Cells.

The impeding ban on per- and polyfluoroalkyl substances (PFAS) prompted researchers to focus on hydrocarbon-based materials as constituents of next-generation proton exchange membranes (PEMs) for polymer electrolyte fuel cells (PEFCs). Here, we report on the fuel cell performance and durability of fluorine-lean PEMs prepared by the post-sulfonation of co-grafted α-methylstyrene (AMS) and 2-methylene glutaronitrile (MGN) monomers into preirradiated 12 µm polyvinylidene fluoride (PVDF) base film. The membranes were subjected to two distinctly different accelerated stress test (AST) protocols performed at open-circuit voltage (OCV): the US Department of Energy-similar chemical AST (90 °C, 30% relative humidity (RH), H/air, 1 bar), developed originally for perfluoroalkylsulfonic acid (PFSA) membranes, and the high relative humidity AST (80 °C, 100% RH, H/O, 2.

Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes.

Background: The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment of malignant melanoma (MM). However, resistance to targeted and immune-checkpoint-based therapies still poses a significant problem.

Objective: Here, we mine large-scale MM proteogenomic data to identify druggable targets and forecast treatment efficacy and resistance.

Transgenic augmentation of erythroferrone in mice ameliorates anemia in adenine-induced chronic kidney disease.

Anemia is a common and disabling complication of chronic kidney disease (CKD). Current therapies can be burdensome, and full correction of anemia is limited by cardiovascular side effects. New approaches that may offer additional therapeutic options are needed.

Comparison of fit and trueness of single-unit and short-span fixed dental restorations fabricated by additive and subtractive manufacturing-A systematic review and meta-analysis.

Objectives: Numerous studies have been conducted on the adaptation of dental restorations fabricated by additive (AM) and subtractive manufacturing (SM); however, the results are conflicting. This systematic review and meta-analysis aimed to evaluate the fit and trueness of fixed restorations made by AM compared to SM.

Data: Studies investigating internal fit, marginal fit, and trueness of fixed prostheses were involved.

Smart medical report: efficient detection of common and rare diseases on common blood tests.

Introduction: The integration of AI into healthcare is widely anticipated to revolutionize medical diagnostics, enabling earlier, more accurate disease detection and personalized care.

Methods: In this study, we developed and validated an AI-assisted diagnostic support tool using only routinely ordered and broadly available blood tests to predict the presence of major chronic and acute diseases as well as rare disorders.

Results: Our model was tested on both retrospective and prospective datasets comprising over one million patients.

What is the minimum time interval for reporting of intraoperative core body temperature measurements in pediatric anesthesia? A secondary analysis.

Given that perioperative normothermia represents a quality parameter in pediatric anesthesia, numerous studies have been conducted on temperature measurement, albeit with heterogeneous measurement intervals, ranging from 30 s to fifteen minutes. We aimed to determine the minimum time interval for reporting of intraoperative core body temperature across commonly used measurement intervals in children. Data were extracted from the records of 65 children who had participated in another clinical study and analyzed using a quasibinomial mixed linear model.

DIAGNOSTIC INVESTIGATION OF AMERICAN ROBINS () WITH FATAL ETHYLENE GLYCOL TOXICOSIS AND CONCURRENT SPP. INFECTION WITH RETROSPECTIVE REVIEW OF 44 YEARS OF DIAGNOSTIC DATA.

We describe a mortality event involving at least 44 adult American robins () that were found dead on the morning of February 25, 2023 in a residential backyard in Natchitoches Parish, Louisiana. Five carcasses were submitted for diagnostic evaluation. All five robins were in good nutritional and feather condition with no external indicators of injury or illness.

[XDR tuberculosis, a challenge not just from a medical point of view].

A young patient from Georgia presented with pulmonary XDR-tuberculosis after months of failed treatment in his home country. Based on genotypic examinations of the sputum samples and a Georgian antibiogram the diagnosis was confirmed and an empirical treatment was started. Despite many initial uncertainties and severe side effects over the course of the treatment, for which treatment adjustments were necessary, the therapy was succesfull with clear clinical and radiological response.

The role of executive functioning in smoking cessation: A scoping review.

Issues: Creating and implementing a plan to successfully quit smoking likely requires executive function (EF) skills such as inhibition, cognitive flexibility, attention and working memory. This scoping review consolidates the research evidence evaluating the role of EF in smoking cessation.

Approach: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR), researchers and a medical librarian searched PubMed, EMBASE, ERIC, CINAHL and PSYCINFO in June 2022, hand-search in September 2022 using relevant MeSH terms, and an updated search was completed in August 2024.

[Experience of setting up a state pharmacovigilance committee during the COVID-19 pandemicExperiencia de la puesta en marcha de un comité estatal de farmacovigilancia durante la pandemia de COVID-19].

Objective: To describe the implementation and pioneering work of a vaccine pharmacovigilance committee in the state of São Paulo, Brazil, for the analysis of events supposedly attributable to vaccination or immunization (ESAVI) during the COVID-19 pandemic.

Methods: This is a retrospective, mixed-methods (qualitative and quantitative) case study focusing on the work carried out by the pharmacovigilance committee in the years 2021 and 2022. The minutes of committee meetings were used to describe how the committee operates.

Validation of the Hungarian Version of the International Consultation on Incontinence Modular Questionnaire on Female Lower Urinary Tract Symptoms (ICIQ-FLUTS).

Urinary incontinence (UI) is a prevalent condition that significantly impacts the quality of life. This study aimed to validate the Hungarian version of the International Consultation on Incontinence Questionnaire-Female Lower Urinary Tract Symptoms (ICIQ-FLUTS) and assess its psychometric properties in the context of the Hungarian population. A cross-sectional study involved 215 Hungarian-speaking women with a mean age of 67.

Non-Invasive Strategies for Remineralization and Hypersensitivity Management in Molar-Incisor Hypomineralization-A Systematic Review and Meta-Analysis.

Molar-incisor hypomineralization (MIH) is an enamel defect affecting molars and incisors, often leading to hypersensitivity, enamel breakdown, and increased caries risk. Non-invasive treatments, such as casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and fluoride varnish, show potential in remineralizing affected enamel and reducing sensitivity, but their efficacy is still debated. This study systematically reviews and analyzes the effectiveness of CPP-ACP and other non-invasive agents in improving remineralization and reducing hypersensitivity in MIH-affected teeth.

The Effect of Combining Femtosecond Laser and Electron Irradiation on Silica Glass.

This study investigates the structural and optical responses of silica glass to femtosecond (fs) laser irradiation followed by high-energy electron (2.5 MeV, 4.9 GGy) irradiation.

Patterns of Childhood Cancer Mortality in Hungary Since the Turn of the Millennium, Including the Two Years of the COVID-19 Pandemic.

: We aimed to analyse the pattern of childhood cancer mortality among children under 15 years in Hungary between 2001 and 2021. In addition, annual and cyclical trends were examined. : The number of deaths was obtained from the nationwide population register over the study period by gender, age group, and region for each year.