A Critical Assessment of Extemporaneous Formulations for Proton Pump Inhibitors: The Importance of Proper Vehicle Selection.

Objective: To examine the influence of vehicles on the stability of extemporaneous suspensions of proton pump inhibitors (PPIs), to single out the formulation most suitable for children, providing appropriate evidence and arguments.

Methods: A review was performed of data identified from Medline, Embase, Science Direct, as well as public digital archive PubMed, including reference texts, related to the field of stability testing of extemporaneous PPI suspensions.

Results: Fourteen selected formulations of extemporaneous suspensions are presented and discussed.

3D Printing-A "Touch-Button" Approach to Manufacture Microneedles for Transdermal Drug Delivery.

Microneedles (MNs) represent the concept of attractive, minimally invasive puncture devices of micron-sized dimensions that penetrate the skin painlessly and thus facilitate the transdermal administration of a wide range of active substances. MNs have been manufactured by a variety of production technologies, from a range of materials, but most of these manufacturing methods are time-consuming and expensive for screening new designs and making any modifications. Additive manufacturing (AM) has become one of the most revolutionary tools in the pharmaceutical field, with its unique ability to manufacture personalized dosage forms and patient-specific medical devices such as MNs.

Novel Drug Delivery Systems Fighting Glaucoma: Formulation Obstacles and Solutions.

Glaucoma is considered to be one of the biggest health problems in the world. It is the main cause of preventable blindness due to its asymptomatic nature in the early stages on the one hand and patients' non-adherence on the other. There are several approaches in glaucoma treatment, whereby this has to be individually designed for each patient.

Microneedles: Characteristics, Materials, Production Methods and Commercial Development.

Although transdermal drug delivery systems (DDS) offer numerous benefits for patients, including the avoidance of both gastric irritation and first-pass metabolism effect, as well as improved patient compliance, only a limited number of active pharmaceutical ingredients (APIs) can be delivered accordingly. Microneedles (MNs) represent one of the most promising concepts for effective transdermal drug delivery that penetrate the protective skin barrier in a minimally invasive and painless manner. The first MNs were produced in the 90s, and since then, this field has been continually evolving.

LIFESTYLE RISK FACTORS AND BONE MASS IN RECURRENT STONE-FORMING PATIENTS: A CROSS-SECTIONAL STUDY IN 144 SUBJECTS.

Patients with urolithiasis, particularly hypercalciuria, may have reduced bone mineral density (BMD). There are numerous risk factors contributing to reduction of BMD such as advanced age, sedentary lifestyle, smoking, low calcium intake, etc. The aim of our study was to investigate the association of lifestyle risk factors and daily intake of milk and dairy products with determinants of BMD in a group of recurrent calcium stone formers (RSF) compared with healthy subjects (HS).

Surgical treatment of liver echinococcosis--open or laparoscopic surgery?

Human echinococcosis remains a significant medical issue in endemic areas. Hydatid cysts can rupture, which is the most severe complication of echinococcosis as it can cause anaphylactic reaction and seeding of secondary cysts. Traditionally, hydatid cysts were evacuated by open surgical procedure in order to remove the entire cyst or by unroofing method, with evacuation of the cyst content.

Evaluation of methods for urine inhibitory potential for precipitation of calcium oxalate.

Renal lithiasis is a significant medical and social problem. Worldwide recurrence is anywhere from 3% to 5%. Objective of this paper is to evaluate two methods for distinguishing between stone formers and non-stone formers.

Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients.

Aim: To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9.

Methods: A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research of the Medical School Osijek, Osijek, Croatia; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267).

Prevalence of metabolic syndrome in the interior of Croatia: the Baranja region.

Metabolic syndrome (MS), a constellation of metabolic risk factors associated with development of cardiovascular diseases and Type 2 diabetes (T2D), has emerged as a public health problem of enormous proportions in developed and developing countries. We have reported previously its prevalence in several island populations of the Eastern Adriatic coast of Croatia. In spite of leading a relatively traditional life style pattern including adherence to a Mediterranean diet, the prevalence of MS in these populations is high and comparable to that in developed nations.

Metabolic evaluation of urolithiasis patients from eastern Croatia.

Metabolic parameters were determined in fasting blood serum, fasting first morning urine, and 24-hour urine of male patients with recurrent calcium oxalate stones (N = 26, age 39.1 +/- 6.2 years) as well as in male healthy controls (N = 18, age 35.

The results after transrectal prostate biopsy with 12 biopsy cores taken.

This report describes the clinical value of transrectal prostate biopsy during which 12 biopsy cores are taken in comparison to the classical sextant method. There were 106 patients included in the study, who had transrectal prostate biopsy (TRB) due to abnormal finding after digitorectal examination (DRE) and/or values of PSA > 4 ng/ml in the period from 4 October 2001 till 14 August 2002. There were 117 biopsies with 12 biopsy cores taken, 6 cores from each lobe.

[The Journal of Slavonian Physicians (Glasnik druztva Slavonskih Liecnika), the journal of the medical society in Croatia 1877-1878].

If we discuss chronological appearance of medical journals as official gazettes of medical associations in this part of the world and Europe, then Glasnik druztva slavonskih liecnika (Glasnik DSL) is the first and the oldest medical journal of this kind in Croatia, whose first number is dated January 1, 1877, and the last December 1, 1878. It is the gazette of the Slavonian Medical Association in Osiek (DSL in Osiek), a professional medical association founded in 1874, which today marks its activity as the Croatian Medical Association--Osijek Branch (HLZ). Our goal was to investigate the key determinants of its appearance in the context of the role and contribution of Slavonian physicians in the promotion and development of Croatian medical literature, particularly medical periodicals in the 19th century.

ESWL treatment of urinary stones in children--the overview of 14 years of experience.

Extracorporeal shock wave lithotripsy (ESWL) treatment has been used at Department of Urology, University Hospital "Osijek", Croatia, since July 1988. Until December 2001 seven thousand and eight hundred patients underwent ESWL for urinary stones, 68 of them were children (0.87%).

Comparison of digital rectal examination and prostate specific antigen in early detection of prostate cancer.

This study compares the value of digital rectal examination (DRE) and prostate specific antigen (PSA) determination in the detection of prostate cancer. 1,000 men aged > or = 50 from the Osijek surroundings were examined. The subjects with prostatitis were excluded from the study.

Role of screening in detection of clinically localized prostate cancer.

The aim of this study was to confirm the role of screening by determining the percentage of clinically localized prostate cancer (stage A and B) in patients with prostate cancer detected on screening and in those presenting to urologic clinic for the symptoms of urination impairment or ostalgia. During the study, 1,000 men aged > or = 50 from the community of Cepin and village of Josipovac near Osijek were examined. The subjects with elevated concentration of total prostate specific antigen and/or digital rectal examination suspect of carcinoma underwent transperineal biopsy of the prostate.

Bone mineral density loss in patients with urolithiasis: a follow-up study.

Background: Recurrent calcium urolithiasis is often associated with disorders of calcium metabolism. The purpose of this investigation was to assess bone mineral content (BMC) and bone mineral density (BMD) over a period of 1 year in patients with urolithiasis and to determine the factors that could have influenced the changes in bone density during that period.

Methods: The patient group comprised 34 men aged 41.

Modification of the Kock's pouch for bladder replacement.

Aim: To describe a modification of the Kock's pouch and present our clinical experience in its application.

Method: After isolating an adequate ileal segment, the bowel is split by a longitudinal incision, with both ends remaining unopened for about 3-4 cm in length. Previously anastomozed ureters are inserted into the proximal end so that a nipple valve is created.

Using buccal mucosa for urethral reconstruction in primary and re-operative surgery.

Objective: Urethral reconstruction using buccal mucosa grafts finds increased broader use in patients with congenital or acquired urethral defects. The authors present their experience of 20 such treated patients. 12 repeatedly operated patients (11 congenital defects, 1 war injury) showed urethral defects of 4.

War injuries of the ureter.

During the 18 months of war in Croatia, from 1991 until 1992, 4,425 wounded patients were treated at Clinical Hospital Osijek. Urogenital injuries were present in 115 treated patients (2.6%), and among them ureteral injuries were present in 11 patients (9.

[War wounds of the external genital organs].

During the 18 months of war in Croatia, from May 1991 to November 1992, 4425 wounded persons were treated at Osijek hospital in Croatia. 115 (2.6%) had urogenital injuries, including 32 cases (27.

War injuries of the kidney.

Between 2 May 1991 and 2 November 1992, 4425 wounded people were treated at the Clinical Hospital of Osijek, Croatia. A hundred and fifteen (2.6 per cent) had a urogenital injury, 64 (56 per cent) of whom had penetrating kidney injuries.

Croatian experience in the treatment of 629 urogenital war injuries.

During the war in Croatia, from April 1991 until November 1993, 33,468 wounded persons were reported, and 24,865 of them were hospitalized. Out of the total number of the hospitalized persons 588 wounded suffered 629 injuries of the urogenital system. This study reports on the experience in the treatment of such injuries at 17 urological and surgical institutions.

Urogenital wounds during the war in Croatia in 1991/1992.

There were 142 war injuries to the urogenital organs in 115 of 4,425 wounded patients treated at our clinical hospital during 18 months of warfare in Osijek, Croatia. Kidney injury was the most common (64 cases) and urethral injury (4) the least common, with a relatively large number of ureteral injuries (11). Two-thirds of the injuries were associated with other trauma, most frequently abdominal injuries.

[Destruction of the General Hospital in Osijek by the Federal Army (13-17 September 1991)].

The article provides documentation on destroyment of General Hospital of Osijek in the period from September 13th until September 17th 1991. By heavy artillery of the Federal army, primarily from garrison "M. Stanivuković" the Hospital was shut 94 times and unnumbered times by bullets from light weapons.