Publications by authors named "Tuba R Caglar"

Autophagy plays a key role in removing protein aggregates and damaged organelles. In addition to its conventional degradative functions, autophagy machinery contributes to the release of cytosolic proteins through an unconventional secretion pathway. In this research, we analyzed autophagy-induced extracellular vesicles (EVs) in HT1080-derived human fibrosarcoma 2FTGH cells using transmission electron microscopy and atomic force microscopy (AFM).

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Article Synopsis
  • Heparanase (HPSE) facilitates cell invasion and metastasis by breaking down extracellular matrix components; the study focused on a new inhibitor, RDS 3337, in glioblastoma cells.
  • Treatment with RDS 3337 increased the expression of autophagy markers like LC3II and p62, indicating disrupted autophagic processes, which corresponded with the activation of cell death mechanisms.
  • The results suggest that HPSE supports autophagy while the inhibition by RDS 3337 shifts the balance towards apoptosis, highlighting its potential as a therapeutic strategy in managing tumor growth.
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Permanent treatment of morbid obesity with medication or diet is nearly impossible. Laparoscopic sleeve gastrectomy (LSG) is becoming a widely accepted treatment option. This study profiled and compared gut microbiota composition before and after LSG.

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