Publications by authors named "Tuba Oz"

Article Synopsis
  • Parkinson's disease (PD) is a neurodegenerative disorder caused by the loss of dopamine-producing neurons, resulting in both motor and non-motor symptoms, with factors like α-synuclein accumulation and oxidative stress playing key roles.
  • MicroRNAs, especially miR-221, are small molecules that regulate gene expression and have been shown to enhance neuronal survival against oxidative stress and influence processes like cell differentiation and apoptosis.
  • Studies indicate that miR-221 could serve as a clinical biomarker for PD, demonstrating protective effects in cell models and potentially modulating the Akt signaling pathway to control cell viability and apoptosis in the context of PD.
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T-cell acute lymphoblastic leukemia (T-ALL) is a type of acute lymphoblastic leukemia from early T-cell progenitors. Interest grows in creating less toxic agents and therapies for chemo-resistant T-ALL cancer. Recently, elemental boron has special properties useful in the creation of new drugs.

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Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, is found in different human tissues and shows diverse regulatory activities in a cell-dependent manner. In the brain, KLF4 controls various neurophysiological and neuropathological processes, and its contribution to various neurological diseases has been widely reported. Parkinson's disease (PD) is an age-related neurodegenerative disease that might have a connection with KLF4.

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Parkinson's disease (PD), characterized by loss of nigrostriatal dopaminergic neurons, is one of the most predominant neurodegenerative diseases affecting the elderly population worldwide. The concept of stem cell therapy in managing neurodegenerative diseases has evolved over the years and has recently rapidly progressed. Neural stem cells (NSCs) have a few key features, including self-renewal, proliferation, and multipotency, which make them a promising agent targeting neurodegeneration.

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