Publications by authors named "Tuan-Ping Cao"
Microbiol Immunol
September 2018
Article Synopsis
- The study identifies the transcription factor GATA1 as being significantly elevated in rheumatoid arthritis (RA) synovial tissues compared to osteoarthritis (OA) tissues, indicating its potential role in RA development.
- It was found that GATA1 expression is promoted by IL-6 through a specific signaling pathway, and when GATA1 is knocked down, it reduces inflammatory cytokine production and cell invasiveness in RA fibroblast-like cells.
- GATA1 functions as a coactivator for the transcription of the iNOS gene, linking its expression to the inflammation seen in RA and suggesting it plays a critical role in the disease's progression and severity.
