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Publications by authors named "Tuan-Jun Hu"

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Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system.
Zhiguang Wu Rakhi Harne Cosmin Chintoan-Uta Tuan-Jun Hu Robert Wallace David A Hume

Dev Comp Immunol

April 2020

Macrophage colony-stimulating factor (CSF1) is an essential growth factor to control the proliferation, differentiation and survival of cells of the macrophage lineage in vertebrates. We have previously produced a recombinant chicken CSF1-Fc fusion protein and administrated it to birds which produced a substantial expansion of tissue macrophage populations. To further study the biology of CSF1 in the chicken, here we generated anti-chicken CSF1 antibodies (ROS-AV181 and 183) using CSF1-Fc as an immunogen.

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Synopsis of recent research by authors named "Tuan-Jun Hu"

  • - Tuan-Jun Hu's research primarily focuses on the role of macrophage colony-stimulating factor (CSF1) in the immune system of chickens, highlighting its significance in macrophage proliferation, differentiation, and survival.
  • - A notable study involved the development of recombinant chicken CSF1-Fc fusion protein, which demonstrated the ability to significantly expand tissue macrophage populations when administered to birds.
  • - The recent findings include generating anti-chicken CSF1 antibodies aimed at further exploring the biology and functional dynamics of CSF1 in avian species, contributing to the understanding of immune responses in chickens.

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