Mechanism exploration of Zoledronic acid combined with PD-1 in the treatment of hepatocellular carcinoma.

How to increase the response of immune checkpoint inhibitors (ICIs) is a challenge. In clinical, we found that Zoledronic acid (ZA) may increase the anti-tumor effect of immunotherapy for hepatocellular carcinoma (HCC). To explore the underlying mechanism, we established a mouse model of HCC by subcutaneously injecting Hepa1-6 cell line.

α-Silylated Diazoalkynes: New Tools for Bioconjugation of Proteins.

α-Silylated diazoalkynes are stabilized diazo compounds that can selectively react with carboxylic residues in buffered aqueous media. In-situ fluoride induced desilylation increases this reactivity, leading to a very fast reaction. Application to the selective functionalization of RNase A, followed by post-functionalization using click chemistry, is described.

Family caregivers' lived experience of caring for hospitalised patients with cancer during the COVID-19 lockdown: A descriptive phenomenological study.

Aims: This study aimed to capture and explore family caregivers' lived experience of caring for hospitalised patients with cancer during the lockdown.

Background: The unprecedented lockdown episodes due to COVID-19 have brought significant changes in the hospital visiting policies and caregiving practices. As part of the precautionary measures for hospital visits, the bedside companion was restricted to one caregiver for patients with cancer in Shanghai hospitals.

Molecular dynamics simulation of water condensation with nucleus under electromagnetic wave irradiation.

The condensation process of water with different nuclei under electromagnetic wave irradiation was studied by molecular dynamics simulation. It was found that there is a different electric-field effect when the condensation nucleus was a small (NH)SO cluster than a CaCO3 nucleus. Through the analysis of the hydrogen-bond number, energy change, and dynamic behavior, we found that the effect of external electric field on the condensation process mainly comes from the change of potential energy caused by the dielectric response and there is a competition effect between the dielectric response and the dissolution in the system with (NH)SO.

'And I thought having a cancer diagnosis was hard': A descriptive phenomenological study of family caregiver experiences navigating the pre-hospital system during COVID-19.

Purpose: Cancer patients usually need frequent hospitalization for diagnosis and treatment. However, the unprecedented outbreak of the Omicron wave in Shanghai pressured local communities and hospitals to enforce strict control measures. This qualitative study aimed to investigate cancer family caregivers' experiences of navigating the pre-hospital system during the lockdown in Shanghai.

Mapping trends and hotspots regarding oral carcinoma and macrophages: a bibliometric analysis of global research.

Background: In recent years, the incidence of oral carcinoma has been increasing year by year, and the role of macrophages in oral carcinoma cannot be ignored. Many related studies have been published, but until now, there is no bibliometric analysis of these publications.

Methods: The global publications about oral carcinoma and macrophages from January 2011 to December 2021 were extracted from Web of Science collection database.

Rapid and Effective Synthesis of α-Acyloxy-α-alkynyltrimethylsilanes.

α-Alkynyl-α'-trimethylsilylhydrazones are readily oxidized into diazo compounds under simple experimental conditions. These stable diazo species can in turn react with a range of carboxylic acids via a protonation-nucleophilic substitution sequence, leading to valuable α-acyloxy-α-alkynyltrimethylsilanes. This procedure avoids the delicate preparation and manipulation of α-hydroxypropargyltrimethylsilanes.

Marker-assisted breeding for transgressive seed protein content in soybean [Glycine max (L.) Merr].

After two cycles of marker-assisted breeding on three loci, lines with transgressive segregation of 8.22-9.32 % protein content were developed based on four original soybean parents with 35.