Publications by authors named "Tu-Wen Chen"
Far-ultraviolet C (far-UVC) light shows promise for pathogen control but its safety and efficacy for corneal disinfection remain unclear. In this study, safe far-UVC dosages were investigated for corneal disinfection and its germicidal performance and oxidative damage potential to 5% povidone-iodine (PVP-I) were compared. Rat corneas were exposed to varying 222 nm far-UVC doses (3-60 mJ/cm) and assessed for ocular damage, apoptosis, and oxidative stress to determine the safe dose of far-UVC.
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- Vitamin B3 supplementation (500 mg/kg/day) was tested in a rat model of anterior ischemic optic neuropathy (rAION) to evaluate its neuroprotective effects over 28 days.
- The results showed that vitamin B3 significantly improved visual function and retinal ganglion cell (RGC) survival compared to the control group treated with phosphate-buffered saline (PBS).
- Additionally, vitamin B3 reduced oxidative stress and apoptosis in the RGCs, indicating its potential to preserve vision during optic nerve injuries.