Publications by authors named "Tu-Trinh H Nguyen"
The ongoing pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), necessitates strategies to identify prophylactic and therapeutic drug candidates for rapid clinical deployment. Here, we describe a screening pipeline for the discovery of efficacious SARS-CoV-2 inhibitors. We screen a best-in-class drug repurposing library, ReFRAME, against two high-throughput, high-content imaging infection assays: one using HeLa cells expressing SARS-CoV-2 receptor ACE2 and the other using lung epithelial Calu-3 cells.
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- The COVID-19 pandemic, caused by the SARS-CoV-2 virus, emerged in 2019, and while developing a vaccine typically takes 12-18 months, finding immediate treatments is critical.
- Researchers screened about 12,000 existing FDA-approved drugs to find 100 molecules that can inhibit the replication of SARS-CoV-2, with 21 showing promising dose-response effects.
- Among the identified drugs, 13 have effective concentrations that could be used safely in patients, including notable candidates like apilimod and MDL-28170, which also showed effectiveness in lab models simulating human lung cells.