Impact of aging on copper isotopic composition in the murine brain.

Aging is the main risk factor for Alzheimer's disease (AD). AD is linked to alterations in metal homeostasis and changes in stable metal isotopic composition can occur, possibly allowing the latter to serve as relevant biomarkers for potential AD diagnosis. Copper stable isotopes are used to investigate changes in Cu homeostasis associated with various diseases.

Copper Isotope Compositions Measured Using a Sapphire Dual Path MC-ICPMS with a Collision/Reaction Cell.

We present a new approach to Cu isotopic measurements using a state-of-the-art Nu Sapphire multicollector inductively coupled plasma source mass spectrometer equipped with a collision/reaction cell (CRC-MC-ICPMS). We investigate the effects of Na doping and Cu concentration mismatch between bracketing standard and unknown samples and demonstrate the efficacy of introducing a He-H gas mix into the CRC to efficiently eliminate the sample matrix-based ArNa isobaric interference on Cu. This capability is crucial when measuring samples with high Na/Cu ratios, such as some biological samples, which have significantly different chemical compositions compared to most geological samples.

Primordial formation of major silicates in a protoplanetary disc with homogeneous Al/Al.

Understanding the spatial variability of initial Al/Al in the solar system, i.e., (Al/Al), is of prime importance to meteorite chronology, planetary heat production, and protoplanetary disc mixing dynamics.

Short time interval for condensation of high-temperature silicates in the solar accretion disk.

Chondritic meteorites are made of primitive components that record the first steps of formation of solids in our Solar System. Chondrules are the major component of chondrites, yet little is known about their formation mechanisms and history within the solar protoplanetary disk (SPD). We use the reconstructed concentrations of short-lived (26)Al in chondrules to constrain the timing of formation of their precursors in the SPD.