Machine learning, advanced data analysis, and a role in pregnancy care? How can we help improve preeclampsia outcomes?

The value of machine learning capacity in maternal health, and in particular prediction of preeclampsia will only be realised when there are high quality clinical data provided, representative populations included, different health systems and models of care compared, and a culture of rapid use and application of real-time data and outcomes. This review has been undertaken to provide an overview of the language, and early results of machine learning in a pregnancy and preeclampsia context. Clinicians of all backgrounds are encouraged to learn the language of Machine Learning (ML) and Artificial intelligence (AI) to better understand their potential and utility to improve outcomes for women and their families.

Discovery of Alkyl Triphenylphosphonium Pinostrobin Derivatives as Potent Anti-Breast Cancer Agents.

Pinostrobin demonstrated anticancer properties, but its hydrophobic feature led to a reduction in bioavailability. The mitochondria-targeted approach successfully synthesized eight new alkyl triphenylphosphonium pinostrobin derivatives (1-8) with good yield in this study. Seven compounds (1-3, 5-8) showed greater cytotoxic potency against the human MCF-7 breast cancer cell line than pinostrobin.

A new apotirucallane-type protolimonoid from the leaves of .

This study presents a phytochemical analysis of the leaves of , revealing the isolation of a new apotirucallane-type protolimonoid, identified as 25--methyl-1,2-dihydroprotoxylocarpin D (), along with two known compounds ( and ). The known compounds were identified as (20,21,23)-21,23-epoxy-7,24,25-trihydroxy-21--methyl-3-oxoapotirucalla-14-ene () and 7,24,25-trihydroxy-3-oxoapotirucalla-14-en-21,23-olide (). The three apotirucallane-type protolimonoids (-) did not exhibit cytotoxicity against MCF-7 cells at a concentration of 100 µM.

A new -carboline-type alkaloid from the flowers of (L.) W.T.Aiton.

In our antioxidant screening of some Vietnamese plant extracts, the CHCl-soluble fraction from (L.) W.T.

A new 7',9-epoxylignan from the stems of .

Bioactivity-guided isolation of the CHCl-soluble fraction of the stems of L. (Celastraceae) was carried out to obtain a new 7',9-epoxylignan () and three 7,9':7',9-diepoxylignans (-). The absolute configuration of was elucidated based on NMR and ECD spectroscopic data interpretation.

Individualized estimates of second cancer risks after contemporary radiation therapy for Hodgkin lymphoma.

Background: Estimates of radiation-related second cancer risk among Hodgkin lymphoma survivors are largely based on radiation therapy (RT) fields and doses no longer in use, and these estimates do not account for differences in normal tissue dose among individual patients. This study gives individualized estimates for the risks of lung and female breast cancer expected with contemporary involved-field RT and low-dose (20 Gy) RT for mediastinal Hodgkin lymphoma.

Methods: Three RT plans were constructed for 37 consecutive patients with mediastinal Hodgkin lymphoma: 35 Gy mantle RT, 35 Gy involved-field RT (IFRT), and 20 Gy IFRT.

A comparison of mantle versus involved-field radiotherapy for Hodgkin's lymphoma: reduction in normal tissue dose and second cancer risk.

Background: Hodgkin's lymphoma (HL) survivors who undergo radiotherapy experience increased risks of second cancers (SC) and cardiac sequelae. To reduce such risks, extended-field radiotherapy (RT) for HL has largely been replaced by involved field radiotherapy (IFRT). While it has generally been assumed that IFRT will reduce SC risks, there are few data that quantify the reduction in dose to normal tissues associated with modern RT practice for patients with mediastinal HL, and no estimates of the expected reduction in SC risk.

Clinical dose-volume histogram analysis in predicting radiation pneumonitis in Hodgkin's lymphoma.

Purpose: To quantify the incidence of radiation pneumonitis (RP) in a modern Hodgkin's lymphoma (HL) cohort, and to identify any clinically relevant parameters that may influence the risk of RP.

Methods And Materials: Between January 2003 and February 2005, 64 consecutive HL patients aged 18 years or older receiving radical mediastinal radiation therapy (RT) were retrospectively reviewed. Symptomatic cases of radiation pneumonitis were identified.