Publications by authors named "Tu Bo"

Molecular structure, external stimuli, and environmental factors all have a strong effect on the internal molecular rotation and vibration of aggregate-induced emission (AIE) luminogens. Here, we report the AIE effect for several newly synthesized amphiphilic tetra(benzimidazole)phenylethene (TBiPE) derivatives and their binuclear N-heterocyclic carbene silver (NHC-Ag) metallacycles in solutions, aggregates, and Langmuir-Blodgett (LB) films. Monolayer behaviors and microscopic images indicate that introducing alkyl chains and binuclear NHC-Ag metallacycles can facilitate the formation of a well-defined insoluble monomolecular layer at the air-water interface.

View Article and Find Full Text PDF

Objective: Angioplasty balloon rupture is a rare complication during percutaneous transluminal angioplasty (PTA). Conventional approach to retrieve circumferentially ruptured balloons is open surgery. This study examined the feasibility of a novel approach which can remove ruptured balloon during PTA in vascular access.

View Article and Find Full Text PDF
Article Synopsis
  • - The study focuses on spontaneous bacterial peritonitis (SBP), a serious complication of liver disease, aiming to improve early diagnosis and treatment to enhance patient survival rates.
  • - Researchers analyzed data from 1,618 patients with liver-related fluid buildup to identify key predictors of SBP, creating a nomogram for diagnosis based on various clinical parameters.
  • - The diagnostic model proved to be effective, showing strong accuracy in both training and validation cohorts, and includes an easy-to-use Excel tool for clinical adoption.
View Article and Find Full Text PDF

For patients with repeated stenosis of autologous arteriovenous fistula, percutaneous transluminal angioplasty (PTA) or bare metal stent placement had limited efficacy. Rapamycin was reported to inhibit neointimal hyperplasia and keep blood vessels patent. In this study, we reported a case with refractory stenosis, i.

View Article and Find Full Text PDF

Controversy still exists regarding how much the inflow arterial percutaneous transluminal angioplasty (PTA) contributed to maintaining fistula function for hemodialysis. We aimed to analyze patency and risk factors after inflow arterial PTA. Hemodialysis patients with inflow arterial primary stenosis who were admitted to our institution from January 2017 to December 2022 were examined.

View Article and Find Full Text PDF

Objectives: Ultrasonography is more frequently used in patients with arteriovenous fistula (AVF) stenosis. The aim of this study is to use sonographic parameters for predicting primary patency in hemodialysis patients with venous valve-related stenosis (VVRS) who are treated by ultrasound-guided percutaneous transluminal angioplasty (PTA).

Methods: A total of 229 VVRS patients who underwent PTA between January 2017 and December 2021 were enrolled.

View Article and Find Full Text PDF

The total occlusion of radial artery is a contraindication for reintervention and further usage. In this study, we report successful revascularization with creation of radiocephalic fistula from post-procedural chronically-occluded radial artery. The completely occluded radial artery was recanalized through ultrasound guided balloon angioplasty.

View Article and Find Full Text PDF
Article Synopsis
  • Recurrent opportunistic infections in severely immunosuppressed AIDS patients persist as a challenge, leading to the development of a new therapy called allogeneic adoptive immune therapy (AAIT) alongside traditional antiretroviral therapy (ART).
  • A phase 2a trial showed that AAIT improved CD4+ T cell recovery compared to ART alone, without increasing adverse events.
  • The study found that factors like donor/recipient sex mismatch significantly influenced the likelihood of achieving an immunological response, indicating AAIT's potential as a valuable treatment for this patient group while highlighting the need for further research to better understand its mechanisms and optimize its use.
View Article and Find Full Text PDF
Article Synopsis
  • - Efferocytosis is an important process where macrophages clear dying cells, helping to control inflammation and prevent further cell death, but its role in acute pancreatitis (AP) is not well understood.
  • - The study found that injured pancreatic tissues from humans and mice showed increased levels of CD47, a molecule that signals cells not to be eaten, and identified its regulation by the transcription factor TRIM28 and the microRNA miR-133a.
  • - Using gene editing and other techniques, the research demonstrated that CD47's role in efferocytosis is key to preventing pancreatic cell death in AP, suggesting that targeting the TRIM28-miR133a-CD47 pathway might be a promising treatment strategy. *
View Article and Find Full Text PDF

Introduction: Venous valve-related stenosis (VVRS) is an uncommon type of failure of arteriovenous fistula among patients with end-stage renal disease (ESRD). There is a paucity of data on the long-term efficacy of ultrasound-guided percutaneous transluminal angioplasty (PTA) for VVRS.

Methods: ESRD patients who underwent PTA because of VVRS between January 2017 and December 2021 at the First Affiliated Hospital of Chongqing Medical University were enrolled.

View Article and Find Full Text PDF

Precision and intelligence in evaluating the complexities of middle ear structures are required to diagnose auriculotemporal and ossicle-related diseases within otolaryngology. Due to the complexity of the anatomical details and the varied etiologies of illnesses such as trauma, chronic otitis media, and congenital anomalies, traditional diagnostic procedures may not yield accurate diagnoses. This research intends to enhance the diagnosis of diseases of the auriculotemporal region and ossicles by combining High-Resolution Spiral Computed Tomography (HRSCT) scanning with Deep Learning Techniques (DLT).

View Article and Find Full Text PDF

The edible fungus industry is one of the pillar industries in the Yunnan-Guizhou Plateau, China. The expansion of the planting scale has led to the release of various mushroom residues, such as mushroom feet, and other wastes, which are not treated adequately, resulting in environmental pollution. This study investigated the ability of black soldier fly (Hermetia illucens L.

View Article and Find Full Text PDF

Background: Chronic cough is a common symptom in patients post the coronavirus disease 2019 (COVID-19). In this study, we aimed to investigate the efficacy of inhaled corticosteroids (ICS) and the clinical characteristics of patients with post-COVID-19 chronic cough during the Omicron era.

Methods: An ambispective, longitudinal cohort study was conducted that included patients with post-COVID-19 who attended the respiratory clinic at our hospital between January 1, 2023, and March 31, 2023 with a complaint of persistent cough lasting more than 8 weeks.

View Article and Find Full Text PDF
Article Synopsis
  • * Among the 20 compounds, 7 were found for the first time in this plant, with their chemical structures determined using NMR and MS spectroscopy techniques.
  • * Notably, three of the isolated compounds showed significant cytotoxic effects on human cancer cell lines A549 and HepG2, suggesting potential anti-cancer properties.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how human adenovirus (HAdV) affects lipid metabolism in infected patients, focusing on those with pneumonia and upper respiratory tract infections (URTI).
  • Researchers analyzed blood samples from 35 patients during acute and recovery stages, finding that most differential metabolites were lipids, particularly in the sphingolipid metabolism pathway.
  • The results indicate that increased levels of ceramide and lactosylceramide in pneumonia patients suggest that targeting lipid metabolism could be a potential treatment strategy against HAdV infections.
View Article and Find Full Text PDF

Acute upper limb ischemia is a rare, potentially limb- or life-threatening vascular emergency that may lead to limb dysfunction or amputation. We present a patient undergoing maintenance hemodialysis who was hospitalized for arteriovenous graft thrombus complicated by acute upper limb ischemia arising from thrombus shedding to the fingertip arteries during thrombolysis. We successfully restored fingertip arterial patency, avoided amputation, and recovered the function of the arteriovenous graft by precise thrombolysis, anticoagulation, correction of arteriospasm, and percutaneous transluminal angioplasty.

View Article and Find Full Text PDF

Bile acids are altered and associated with prognosis in patients with acute pancreatitis (AP). Here, we conduct targeted metabolomic analyses to detect bile acids changes in patients during the acute (n = 326) and the recovery (n = 133) phases of AP, as well as in healthy controls (n = 60). Chenodeoxycholic acid (CDCA) decreases in the acute phase, increases in the recovery phase, and is associated with pancreatic necrosis.

View Article and Find Full Text PDF

Bidirectional signal transduction between tumor epithelial cells and tumor microenvironment (TME) is important for tumor development. Here we show that Lin28b/let-7 pathway is indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulates Lin28b in cancer-associated fibroblasts (CAFs). Moreover, we demonstrate that Lin28b in CAFs promoted growth of PDAC by inducing cytokine PCSK9's production.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the effectiveness and safety of combining radiofrequency ablation (RFA) with the anti-PD-1 drug toripalimab for treating recurrent hepatocellular carcinoma (HCC).
  • In a trial with 40 patients, the combination therapy resulted in a significantly better median recurrence-free survival (RFS) rate of 15.40 months compared to just 8.2 months for those receiving only RFA.
  • The results indicate that this combination therapy is safe and particularly beneficial for younger patients, males, and those categorized as Child-Pugh grade A.
View Article and Find Full Text PDF

Background And Aims: The microbial spectrum and antimicrobial resistance patterns change over time and vary across regions in patients with spontaneous bacterial peritonitis (SBP). There is an urgent need to clarify the factors associated with in-hospital mortality in these patients.

Methods: In this study, 377 patients with SBP and 794 patients with bacterascites were analyzed for the microbial spectrum, antimicrobial resistance profiles, and laboratory findings.

View Article and Find Full Text PDF

Background: Identifying a metastasis-correlated immune cell composition within the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) will help to develop promising and innovative therapeutic strategies. However, the dynamics of immune cell lineages in the TME of advanced PDAC remains elusive.

Methods: Twenty-six samples from 11 patients (including 11 primary tumor tissues, 10 blood, and 5 lymph nodes) with different stages were used to develop a multiscale immune profile.

View Article and Find Full Text PDF

Background: To investigate the clinical outcomes of indwelling needle-delivered local urokinase thrombolysis, a cost-saving thrombolytic approach, in the treatment of thrombosed arteriovenous grafts (AVGs).

Methods: The clinical data of 71 patients with a first episode of thrombosed AVG were analyzed. Among them, 49 patients underwent urokinase thrombolysis and percutaneous transluminal angioplasty (PTA), and 22 patients underwent thrombectomy and PTA.

View Article and Find Full Text PDF

Background: Left brachiocephalic vein (LBCV) stenosis is a common complication in hemodialysis patients and is a heterogenous disorder associated with either prior catheterization or extrinsic compression. This study aimed to characterize patients with LBCV stenosis or occlusion with and without a history of central venous catheterization.

Methods: We performed a retrospective study in 84 hemodialysis patients with LBCV stenosis or occlusion with ( = 22) or without ( = 62) prior catheterization.

View Article and Find Full Text PDF

DNA damage repair (DDR) is a double-edged sword with different roles in cancer susceptibility and drug resistance. Recent studies suggest that DDR inhibitors affect immune surveillance. However, this phenomenon is poorly understood.

View Article and Find Full Text PDF