Utilization of international normalized ratio-derived formula to predict plasma rivaroxaban level-Validation study and real-world experience.

Introduction: Specific assays of plasma rivaroxaban level are not always readily available with short turnaround time, which hamper the management of urgent clinical situations. In this study, we aimed to build a predictive formula of plasma rivaroxaban levels from international normalized ratio (INR) value and validated in real world clinical situations.

Methods: Ninety-four patients who were taking rivaroxaban participated in the study.

Plasma apixaban levels in Chinese patients with chronic kidney disease-Relationship with renal function and bleeding complications.

Accumulation of apixaban in plasma is a major concern in patients with chronic kidney disease (CKD). Studies that investigated plasma apixaban level in CKD patients and its association with clinically significant events are scarce. Patients with CKD Stage 1-4 who were taking apixaban, either 2.