Publications by authors named "Tsz Yui Zhuang"
Proteomic communications in neighboring microenvironments during early organ development is a dynamic process that continuously reshapes human embryonic stem cells (hESCs) developmental fate. Such dynamic proteomic alteration in the microenvironment consists of both freely secreted proteome and exosome-encapsulated proteome. Simultaneous monitoring of the time-lapse shift of both proteomes with live organoids remains technically challenging.
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- Bisphenol S (BPS) is a common plasticizer that poses potential risks to fetal brain development, but its effects are not well understood.
- Researchers developed a microfluidic chip to grow cerebral organoids and study the neurotoxicity of low-dose BPS over 34 days, exposing them to BPS for two weeks starting on day 20.
- Results showed that BPS exposure inhibited neuron differentiation, disrupted the Wnt signaling pathway, and altered signaling molecule expressions, suggesting that even low doses can be harmful during fetal brain development.