Dopamine partial agonists and prodopaminergic drugs for schizophrenia: Systematic review and meta-analysis of randomized controlled trials.

Dopaminergic dysfunction is thought to be central to schizophrenia symptomatology. Previous meta-analyses of prodopaminergic drugs in schizophrenia have important limitations, and also did not include dopamine D2/D3 partial agonists. We investigated the effect of medications which increase dopamine signalling on schizophrenia symptoms by meta-analysing double-blind, placebo-controlled RCTs.

The clinical significance of duration of untreated psychosis: an umbrella review and random-effects meta-analysis.

The idea that a longer duration of untreated psychosis (DUP) leads to poorer outcomes has contributed to extensive changes in mental health ser-vices worldwide and has attracted considerable research interest over the past 30 years. However, the strength of the evidence underlying this notion is unclear. To address this issue, we conducted an umbrella review of available meta-analyses and performed a random-effects meta-analysis of primary studies.

Pre-Operative Imaging can Reduce Negative Appendectomy Rate in Acute Appendicitis.

Introduction: Acute appendicitis is a common surgical emergency, with a prevalence of 112 per 100,000 people per year in Europe. Negative appendicectomy is defined as a pathologically normal appendix removed from patient suspected with appendicitis. Negative appendectomy rate (NAR) has been reported to be around 15-25%.

The 100 most cited manuscripts in coronary artery bypass grafting.

Introduction: To gain a better understanding of the progression of coronary artery bypass grafting (CABG) and its impact on clinical practice, bibliometric citation analysis can be performed. Bibliometric citation analysis is a method of determining the most influential papers on a topic based on several citations and impact factor.

Method: A search of the Thomson Reuters Web of Science citation indexing database and research platform was completed using the terms "CABG," "Coronary artery bypass graft," "Coronary artery," "bypass," and/or "bypass grafting.