Spermicidal and anti-Trichomonas vaginalis activity of Brazilian Sapindus saponaria.

Background: Sapindus saponaria is used traditionally for curing ulcers, external wounds and inflammations. The spermicidal and anti-Trichomonas activity of S. saponaria and its effect on Lactobacillus acidophilus were evaluated.

In vivo activity of Sapindus saponaria against azole-susceptible and -resistant human vaginal Candida species.

Background: Study of in vivo antifungal activity of the hydroalcoholic extract (HE) and n-BuOH extract (BUTE) of Sapindus saponaria against azole-susceptible and -resistant human vaginal Candida spp.

Methods: The in vitro antifungal activity of HE, BUTE, fluconazole (FLU), and itraconazole (ITRA) was determined by the broth microdilution method. We obtained values of minimal inhibitory concentration (MIC) and minimum fungicide concentration (MFC) for 46 strains of C.

Microwave effect on the surface composition of the Urushibara Ni hydrogenation catalyst and improved reduction of acetophenone.

The Urushibara Ni (U-Ni) hydrogenation catalyst and some modified forms, and for comparison Raney-Ni, were subjected to conventional (oil bath) and MW heating, and subsequently characterized by electron dispersive X-ray analysis (EDX), by BET surface area, and by scanning electron microscopy (SEM); yields of the catalyzed hydrogenation of acetophenone to 1-phenylethanol in 2-propanol by one of the modified forms (U-Ni-B) were greatly improved (from 68% to 95%).

Antifungal activity of the extracts and saponins from Sapindus saponaria L.

Extracts from the dried pericarp of Sapindus saponaria L. (Sapindaceae) fruits were investigated for their antifungal activity against clinical isolates of yeasts Candida albicans and C. non-albicans from vaginal secretions of women with Vulvovaginal Candidiasis.

Diagnostic usefulness of postexercise systolic blood pressure response for detection of coronary artery disease in patients with electrocardiographic left ventricular hypertrophy.

Patients with left ventricular (LV) hypertrophy often have a positive result on exercise testing despite a normal coronary arteriogram. This indicates that exercise-induced ST depression is not always an accurate indicator of the presence of coronary artery disease (CAD) in such patients. We evaluated the usefulness of the postexercise systolic blood pressure (BP) response for detection of CAD in 51 patients with both electrocardiographic evidence of LV hypertrophy and positive ST depression on treadmill exercise testing.

Long-term effects of niceritrol on serum lipoprotein(a) and lipids in patients with high levels of lipoprotein(a).

The long-term effects of niceritrol on lipoprotein(a) (Lp[a]), lipids, apolipoproteins, and fibrinogen and fibrinolytic factors were evaluated in 20 outpatients who had serum Lp(a) levels higher than 20 mg/dL. The mean ( +/- SE) levels of Lp(a) decreased from 33.6 +/- 2.

Characteristic findings on the standard 12-lead ECG in patients with the fasciculoventricular Mahaim fiber.

Standard 12-lead electrocardiograms with a Q wave in lead V1 were obtained from 32 subjects without organic cardiac disease and analyzed for features that might characterize an abnormal atrioventricular conduction through the fasciculoventricular Mahaim fiber. Following an infusion of ajmaline, the Q wave in V1 vanished abruptly and changed to an rS pattern in the 12 ajmaline responders. Discriminant analysis was performed to distinguish the ajmaline responders from the others.

Blood coagulability and fibrinolytic activity before and after physical training during the recovery phase of acute myocardial infarction.

The effects of physical training on hemostatic parameters were evaluated in 56 postmyocardial infarction (MI) patients before and after one month of systematic physical training and in 30 control post-MI patients, who did not undergo such training. There were no significant changes in prothrombin time (PT) and alpha 1-antitrypsin (alpha 1AT) at the beginning and end of the study in either group. Levels of fibrinogen, Factor VIII: C (VIII:C) and von Wildebrand antigen (vWf:Ag), and activities of ATIII and plasminogen (Plg) were significantly decreased in the group with physical training (p less than 0.

Elevation of factor VII activity and mass in coronary artery disease of varying severity.

The present study was undertaken to determine whether the extent of Factor VII elevation correlated with the severity of coronary artery disease and whether zymogen or activated Factor VII was responsible for this elevation. A group of 69 patients with coronary artery disease with old myocardial infarction was compared with 28 control subjects. The patient groups showed elevated levels of Factor VII procoagulant activity (FVII:C) and more markedly elevated Factor VII antigen (FVII:Ag) levels than the control group; therefore they had a decreased FVII:C to FVII:Ag ratio.

Prognostic value of abnormal postexercise systolic blood pressure response: prehospital discharge test after myocardial infarction in Japan.

To assess the prognostic value of an abnormal postexercise response in systolic blood pressure (SBP), treadmill exercise testing was performed in 217 survivors of acute myocardial infarction at an average of 9.3 weeks after infarction. During the mean follow-up period of 4 years, cardiac events were noted in 34 patients (16%), including cardiac death in 13 (6%), nonfatal reinfarction in 12 (6%), and coronary artery bypass graft surgery in nine (4%).

The effect of ceruletide on tardive dyskinesia: a double-blind placebo-controlled study.

1. In a double-blind placebo-controlled study of 37 patients with tardive dyskinesia, the therapeutic effect of ceruletide was evaluated. 2.

Evidence for the existence of a thermolabile element in adenovirus type 5 that plays a role during an early stage of infection.

In an attempt to learn the molecular mechanism behind the initial steps (before genome expression) of adenovirus infection, the effect of temperature treatment of adenovirus type 5 particles on their infectivity was studied. It was found that adenovirus type 5 could be inactivated by temperature treatment at between 43 and 44 degrees C. Both biochemical and biophysical examination of adenovirus particles failed to disclose any significant changes after exposure to temperatures up to 45 degrees C.

An unexpected effect of divalent cations on the adenovirus endogenous protein kinase: alteration in the specificity of phosphorylation.

The adenovirus endogenous protein kinase specifically phosphorylates capsid protein IIIa in the presence of Mg2+, utilizing either ATP or GTP as a phosphate donor. When Mn2+ is substituted for Mg2+, in the presence of ATP, phosphorylation of IIIa is enhanced by 2-3 fold. However, in addition to IIIa phosphorylation, the core proteins V and VII are now phosphorylated.

Evidence for the ubiquitous presence of a protein kinase in human adenoviruses capable of preferentially phosphorylating capsid protein IIIa.

Several years ago a protein kinase activity was demonstrated in subgroup C adenoviruses. In this report we have demonstrated the presence of a similar protein kinase activity in adenoviruses of subgroups A, B, and D; like the subgroup C adenovirus kinase, it preferentially phosphorylates capsid protein IIIa. Further, we have shown that the protein kinase activity is independent of the host cell line used to grow the virus and is not inhibited by N-tosyl-L-lysine chloromethyl ketone or by N-tosyl-L-phenylalanine chloromethyl ketone (known inhibitors of other protein kinases).

Evaluation of left atrial rhythm with pulsed Doppler echocardiography.

To evaluate the origin of ectopic atrial rhythms, the beginning of atrioventricular inflow due to left and right atrial ejection was estimated using the pulsed Doppler combined with two-dimensional echocardiography. In ten normal controls, the beginning of transtricuspid flow due to atrial ejection preceded that of transmitral by 0 to 40 msec with an average of 22 msec. In contrast, the beginning of right atrial ejection flow lagged behind that of left atrial by 40 to 80 msec in case 1 and by 20 to 50 msec in case 2 of ectopic atrial rhythm.

[Quantitative analysis of exercise 201Tl myocardial emission CT in patients with coronary artery disease].

The clinical usefulness of quantitative analysis of exercise thallium-201 myocardial emission computed tomography (ECT) was evaluated in coronary artery disease (CAD). The subjects consisted of 20 CAD patients and five normal controls. All CAD patients underwent coronary angiography.

Correlation between the direction of the interventricular septum estimated with transmission computed tomography and the initial QRS vectors.

A correlative study was performed to relate the interventricular septal angle (As degrees) evaluated by transmission computed tomography to the azimuth of initial QRS vectors in 52 patients. Patients were divided into five groups: RV volume overloading (RVO), RV pressure overloading (RSO), LV volume overloading (LVO), LV pressure overloading (LSO), and normal control with no cardiopulmonary disease. For measurement of As degrees, the leftward and forward directions were designated as zero and 90 degrees, respectively.

[Quantitative correlation between thallium-201 myocardial emission computed tomography and left ventriculography in old myocardial infarction].

We evaluated a clinical usefulness of quantitative analysis of myocardial emission computed tomographic (ECT) images in 28 patients with old myocardial infarction and 10 healthy volunteers. Circumferential profile analysis was performed in five or six short-axial images of the left ventricle reconstructed from ECT. Mean regional anterior, inferoposterior, lateral and septal percent thallium uptakes were calculated from three short-axial (basal, central and apical) images.

The adenovirus type 5 capsid protein IIIa is phosphorylated during an early stage of infection of HeLa cells.

[32P]Orthophosphate-preincubated and thus 32P-labeled ATP-containing HeLa cells were infected with adenovirus type 5 particles. Following a 30 min infection period, viral particles were recovered and purified from infected cells by means of sucrose gradient and CsCl equilibrium centrifugation. Analysis of such recovered adenovirus particles by gel electrophoresis revealed that the capsid protein IIIa was phosphorylated.

Comparative evaluation of depressed automaticity in sick sinus syndrome by Holter monitoring and overdrive suppression test.

To ascertain whether the long cardiac pauses on the Holter ECGs of patients with the sick sinus syndrome were related to the spontaneously occurring overdrive suppression, the heart rates for the 12 seconds preceding the cardiac pauses longer than 5 seconds were compared with that averaged for 24 hours. Even in six out of seven patients with bradycardia-tachycardia syndrome the former rate was not significantly greater than the latter, indicating that episodes of such long cardiac pauses may not result from spontaneously occurring overdrive suppression. This observation was also consistent with the result that no statistically significant correlation was obtained between the maximum pauses measured from Holter ECGs of sick sinus syndrome and those obtained by the overdrive suppression test.

Experimental studies on sick sinus syndrome: relationship of extent of right atrial lesions to subsidiary pacemaker shift and its function.

An area where the sinus node was located in 36 dogs was defined as the "SN-area." Five to 7 days after cauterization of the SN-area, a subsidiary pacemaker remained in the SN-area in seven (group S) and shifted to outside the SN-area in 14 dogs (group E). The SN-area in group S had escaped complete destruction, but that in group E was destroyed completely.

Temporal behavior of abrin in the intoxication of Chinese hamster cells (line CHO).

Abrin, a potent cytotoxin, was utilized as a probe to elucidate the mechanism by which external proteins are delivered to the cytoplasm of mammalian cells. Abrin bound rapidly to the surface receptors of the Chinese hamster cells (line CHO) and appeared to be internalized immediately without any significant lag. The maximum level of abrin internalization was achieved within eight minutes, based on both biochemical and electron microscopic autoradiographic studies with [125I]abrin.