Impact of Weekly Teriparatide on the Bone and Mineral Metabolism in Hemodialysis Patients With Relatively Low Serum Parathyroid Hormone: A Pilot Study.

Adynamic bone disease in HD patients is characterized by skeletal resistance to parathyroid hormone (PTH) or suppression of PTH release, leading to a downregulated bone turnover and bone fracture. Hence, we examined the efficacy of weekly teriparatide for HD patients with low PTH indicating adynamic bone disease without a history of parathyroidectomy. Fifteen HD patients with low PTH were recruited in this prospective observational study.

Genome Sequencing Verifies Relapsed Infection of .

Background: Recurrent infections of are often reported, and long-term antimicrobial treatment is empirically recommended to prevent such infections. However, there have been no studies examining whether recurrent infections are relapses of former infections or reinfections with different clones.

Methods: A 69-year-old woman presented with recurrent bacteremia-associated cellulitis after a 51-day interval.

Thrombotic microangiopathy secondary to steroid pulse therapy administered for refractory nephrotic syndrome.

A 79-year-old woman with familial hyperlipidemia was treated with low-density lipoprotein apheresis. She was hospitalized due to fatigue and edema, and massive proteinuria was discovered. Renal biopsy revealed no distinct abnormalities, thus suggesting a diagnosis of minimal change nephrotic syndrome.

Predicting the outcome of chronic kidney disease by the estimated nephron number: the rationale and design of PRONEP, a prospective, multicenter, observational cohort study.

Background: The nephron number is thought to be associated with the outcome of chronic kidney disease (CKD). If the nephron number can be estimated in the clinical setting, it could become a strong tool to predict renal outcome. This study was designed to estimate the nephron number in CKD patients and to establish a method to predict the outcome by using the estimated nephron number.

Liquid-liquid extraction of alkali metal ions with photochromic crowned spirobenzopyrans.

On the liquid-liquid extraction using 1,2-dichloroethane as an organic solvent, the crowned spirobenzopyrans exhibited textractability in the following order: Li+ >> Na+ > K+ > or = tetramethylammonium ion (TMA+), Li+ > Na+ >> K+ > TMA+, and Na+ > K+ >> Li+ > TMA+ for spirobenzopyran derivatives bearing monoaza-12-crown-4, 1; monoaza-15-crown-5, 2; and monoaza-18-crown-6, 3; respectively, under dark conditions. The ion selectivity of 1 depends on the metal-ion complexing ability of monoaza-12-crown-4. Even 2, which carries a 15-crown-5 moiety, showed Li+ selectivity because of the much stronger interaction of Li+ with the phenolate ion of the merocyanine form of 2 than that of Na+.

Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas.

For the metastasis and invasion of cancer cells, destruction of extracellular matrix is essential. In this process, collagen is broken down by some matrix metalloproteinases. Matrix metalloproteinase 2 (MMP2) is able to cleave type IV collagen, and membrane-type-1-matrix metalloproteinase (MT1-MMP) induces activation of proMMP2.