Publications by authors named "Tsuyoshi Matsumoto"

: Changes in activities of daily living (ADL) and quality of life (QOL) of patients with bone metastasis who underwent surgical treatment through Bone Metastasis Cancer Boards (BMCBs), a recent multidisciplinary approach for managing bone metastases, have been reported; however, no reports exist on patients who undergo conservative treatment. In this study, we aimed to evaluate these patients' ADL and QOL and examine the factors influencing changes in these parameters. : We retrospectively reviewed 200 patients with bone metastases who underwent conservative therapy through BMCBs between 2013 and 2021.

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  • - The study aimed to evaluate how the percentage of visceral adipose tissue (VAT%) affects outcomes of minimally invasive surgery in obese women with endometrial cancer.
  • - Conducted at Mie University Hospital, it analyzed data from 73 obese patients, comparing results between those who underwent robotic surgery and laparoscopic surgery from 2014 to 2022.
  • - The findings indicated that VAT% is a stronger predictor of operative time and blood loss than body mass index (BMI), suggesting it could be a useful indicator for surgical outcomes in this patient demographic.
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  • - The study investigated the effectiveness of acute rehabilitation, specifically physiotherapy (PT), for patients with severe COVID-19 in an ICU setting, comparing outcomes for those who received PT to those who did not.
  • - A total of 98 patients were analyzed, with findings showing that the PT group, who were generally older and had more severe health challenges, demonstrated significant improvements in their activities of daily living (ADL) by discharge compared to their initial state.
  • - Conclusions suggest that older patients with severe COVID-19, especially those with longer hospital stays or requiring mechanical ventilation, are likely to benefit from early physiotherapy intervention to mitigate declines in daily functioning.
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  • In Japan, there is a lack of research on how deceased donor liver transplantation (DDLT) affects sarcopenia, so this study focused on changes in skeletal muscle mass and quality in 23 patients over time.
  • Results indicated significant reductions in skeletal muscle mass during hospitalization, with many patients not recovering to pre-transplant levels one year post-DDLT.
  • The study concluded that while DDLT may improve muscle quality, the loss of muscle mass during treatment does not appear to correlate with survival outcomes after transplantation.
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Objectives: Increased long-term impairment is common among intensive care unit (ICU) survivors. However, predictors of activities of daily living (ADL) in ICU survivors are poorly understood. We aimed to focus on the trajectory of physical function and explore the clinical variables that affect ADL at hospital discharge.

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Unlabelled: A 56-year-old man presented with fever, cough, and bloody sputum. He had undergone mitral valve replacement with mechanical prosthesis 14 months prior for mitral valve disease. Subsequently, the patient was taking warfarin and amiodarone.

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  • The study investigates the reliability and validity of measuring skeletal muscle thickness using ultrasonography (US), specifically focusing on quadriceps muscle in healthy men.
  • It found that intra-rater and inter-rater reliability of these measurements were excellent, suggesting consistency among different testers.
  • Additionally, there were significant correlations between quadriceps thickness and muscle strength as well as leg muscle mass, indicating that US muscle assessments could be a practical alternative in clinical settings.
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To determine the impact of the coverage of risk-reducing salpingo-oophorectomy (RRSO) and mastectomy (RRM) as well as genetic testing for BRCA pathogenic variants by the national insurance system in Japan. We compared the clinical background of women who underwent RRSO at our institution before and after its coverage by the national insurance system. Those who underwent RRSO between January 2017 and December 2019 and between April 2020 and March 2022 were classified as Period.

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An earthquake with a magnitude of 8 or 9 is predicted to occur near the Ryukyu Islands in Japan, for which the Okinawa Prefecture is preparing countermeasures. Evacuating people to a safe shelter within the tsunami arrival time is a crucial countermeasure. This study aims to understand the vulnerabilities of patients with chronic respiratory diseases in southern parts of Okinawa during a tsunami evacuation, thereby calculating evacuation distance of vulnerable patients and creating individual evacuation plans.

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Introduction: In Japan, endometrial cytology is widely performed to evaluate the status of the endometrium in women with suspected endometrial cancer. A new classification system for endometrial cytology has recently been used: the Yokohama system, based on a descriptive reporting format. This study aimed to clarify the triage for patients with atypical endometrial cells of undetermined significance (ATEC-US) when followed by negative endometrial cytology.

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Aim: Extended-field concurrent chemoradiation therapy (Ex-CCRT) has been widely used for para-aortic lymph node (PAN) metastases confirmed by radiographic assessment without surgical exploration. The objective of this prospective study was to evaluate the clinical value of laparoscopic retroperitoneal PAN biopsy in locally advanced cervical cancer (LACC) with pelvic lymph node (PLN) metastases.

Methods: From May 2017 to March 2020, stage IIB-IIIB cervical cancer patients who were diagnosed with PLN metastasis using positron emission tomography-computed tomography (PET-CT) with maximum standardized uptake value (SUVmax) ≥2.

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Obturator nerve injury is an uncommon complication frequently associated with pelvic gynecologic or urologic cancer surgery. It can lead to disability or adversely affect quality of life. Large segmental defects are particularly difficult to manage as the limited mobility of the nerve prevents tension-free direct end-to-end anastomosis.

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Constructing synthetic models of the nitrogenase P -cluster has been a long-standing synthetic challenge. Here, we report an optimal nitrogenase P -cluster model [{(TbtS)(OEt )Fe S } (μ-STbt) (μ -S)] (2) [Tbt=2,4,6-tris{bis(trimethylsilyl)methyl}phenyl] that is the closest synthetic mimic constructed to date. Of note is that two thiolate ligands and one hexacoordinated sulfide are connecting the two Fe S incomplete cubanes similar to the native P -cluster, which has never been achieved.

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A dithiolate/hydride bridged Fe-Ni complex, [(CN)(CO)Fe(μ-pdt)(μ-H)Ni(CN)(PCy)] (, pdt = propane-1,3-dithiolate) has been synthesized by the reaction of [(CN)(CO)Fe(pdt)] with [Ni(Cl)(H)(PCy)] as a synthetic analogue of the Ni-R state of the active site of the [Ni-Fe] hydrogenase. X-ray crystallography of this model complex suggests that the hydride unsymmetrically binds to Ni and Fe similar to natural [Ni-Fe] hydrogenases.

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Background and Purpose- Endovascular therapy is effective against acute cerebral large vessel occlusion (LVO). However, many patients do not receive such interventions because of the lack of timely identification of the type of stroke. If the types of stroke (any stroke, LVO, intracranial hemorrhage [ICH], and subarachnoid hemorrhage [SAH]) were to be predicted at the prehospital stage, better access to appropriate interventions would be possible.

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An unprecedented, super oxidized all-ferric iron-sulfur cubanoid cluster with all terminal thiolates, Fe S (STbt) (3) [Tbt=2,4,6-tris{bis(trimethylsilyl)methyl}phenyl], has been isolated from the reaction of the bis-thiolate complex Fe(STbt) (2) with elemental sulfur. This cluster 3 has been characterized by X-ray crystallography, zero-field Fe Mössbauer spectroscopy, cyclic voltammetry, and other relevant physico-chemical methods. Based on all the data, the electronic ground state of the cluster has been assigned to be S =0.

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The aim of the study was to examine the relationship between the brain natriuretic peptide (BNP) level and prognosis of diabetic nephropathy. The subjects were 100 Japanese outpatients with type 2 diabetes mellitus with microalbuminuria. Associations between metabolic parameters at baseline, including BNP, and prognosis of diabetic nephropathy (progression of diabetic nephropathy, cardiovascular events, and death) were examined for 7 years.

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We propose an image analysis method for quality evaluation of human pluripotent stem cells based on biologically interpretable features. It is important to maintain the undifferentiated state of induced pluripotent stem cells (iPSCs) while culturing the cells during propagation. Cell culture experts visually select good quality cells exhibiting the morphological features characteristic of undifferentiated cells.

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Objective: To evaluate the effect of dienogest (DNG) in preventing the occurrence of pain and endometriomas after laparoscopic resection of uterosacral ligaments (USLs) with deep infiltrating endometriosis (DIE).

Study Design: This retrospective analysis included 126 patients who underwent laparoscopic resection of USLs with DIE followed by postoperative administration of DNG or no medication. Every 6 months postoperatively, patients answered questions and underwent ultrasound examination to identify pain and/or endometrioma.

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The syntheses and characterization of two new porphyrin-based metal-organic frameworks (P-MOFs), through the complexation of 5,10,15,20-tetra-4-pyridyl-21 H,23 H-porphine (H2 TPyP) and copper(II) acetate (CuAcO) in the presence of the fullerenes C60 or C70 are reported. Complex 1 was synthesized in conjunction with C60 , and this reaction produced a two-dimensional (2D) porous structure with the composition CuAcO-CuTPyP⊃m-dichlorobenzene (m-DCB), in which C60 molecules were not intercalated. Complex 2 was synthesized in the presence of C70 , generating a three-dimensional (3D) porous structure, in which C70 was intercalated, with the composition CuAcO-CuTPyP⋅C70 ⊃m-DCB⋅CHCl3 .

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Heterolytic activation of dihydrogen molecule (H2) by hydroxo-/sulfido-bridged ruthenium-germanium dinuclear complex [Dmp(Dep)Ge(μ-S)(μ-OH)Ru(PPh3)](+) (1) (Dmp = 2,6-dimesitylphenyl, Dep = 2,6-diethylphenyl) is theoretically investigated with the ONIOM(DFT:MM) method. H2 approaches 1 to afford an intermediate [Dmp(Dep)(HO)Ge(μ-S)Ru(PPh3)](+)-(H2) (2). In 2, the Ru-OH coordinate bond is broken but H2 does not yet coordinate with the Ru center.

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[4Fe-4S] clusters modeled after those in organisms having three cysteine thiolates and one carboxylate were synthesized by using the tridentate thiolato chelate. X-ray structural analysis reveals that the carboxylates coordinate to the unique irons in an η(1) manner rather than η(2). Redox potentials show a positive shift from that of the cluster having ethanethiolate and the tridentate thiolato chelate.

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Aims: We examined the relationship between the brain natriuretic peptide (BNP) level and renal function in diabetic nephropathy with microalbuminuria.

Methods: The subjects were 97 Japanese type 2 diabetes mellitus outpatients with microalbuminuria. Associations between the annual rate of decline in estimated glomerular filtration rate (eGFR) and various metabolic parameters at baseline (BMI, systolic blood pressure, HbA1c, LDL cholesterol, urine albumin-creatinine ratio, BNP and eGFR) were examined.

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Insulin secretion by pancreatic islets is a multicellular process. In addition to other essential systems, gap junctions are an important component of cell-to-cell communication in pancreatic islets. It is well known that dysfunction of gap junctions causes inappropriate insulin secretion.

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We have designed new trithiols Temp(SH)(3) and Tefp(SH)(3) that can be synthesized conveniently in short steps and are useful for preparation of crystalline [3:1] site-differentiated [4Fe-4S] clusters suitable for X-ray structural analysis. The ethanethiolate clusters (PPh(4))(2)[Fe(4)S(4)(SEt)(TempS(3))] (4a) and (PPh(4))(2)[Fe(4)S(4)(SEt)(TefpS(3))] (4b) were prepared as precursors, and the unique iron sites were then selectively substituted. Upon reaction with H(2)S, (PPh(4))(2)[Fe(4)S(4)(SH)(TempS(3))] (6a) and (PPh(4))(2)[Fe(4)S(4)(SH)(TefpS(3))] (6b), which model the [4Fe-4S] cluster in the β subunit of (R)-2-hydroxyisocaproyl-CoA dehydratase, were synthesized.

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