Publications by authors named "Tsutsui T"

Background: Low-frequency acupuncture is used to maintain skeletal muscle flexibility and improve joint range of motion; however, its definite effects are unclear. This study aimed to determine the effects of low-frequency acupuncture on muscle and fascial stiffness and ankle dorsiflexion range of motion.

Methods: The participants included 12 randomly selected healthy adults.

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Many genetic and environmental factors are involved in the development and progression of diabetic kidney disease (DKD), and its pathology shows various characteristics. Animal models of DKD play an important role in elucidating its pathogenesis and developing new therapies. In this study, we investigated the pathophysiological features of two DKD animal models: db/db mice (background of hyperglycemia) and KK-Ay mice (background of hyperinsulinemia).

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Leveraging the features of the GstLAL pipeline, we present the results of a matched filtering search for asymmetric binary black hole systems with heavily misaligned spins in LIGO and Virgo data taken during the third observing run. Our target systems show strong imprints of precession whereas current searches have nonoptimal sensitivity in detecting them. After measuring the sensitivity improvement brought by our search over standard spin-aligned searches, we report the detection of 30 gravitational wave events already discovered in the latest version of the Gravitational Wave Transient Catalog.

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Background: Radial pressure wave (RPW) has been introduced to sports sites as an alternative tool to massage, and there have been reports of irradiating muscles. This study aimed to clarify the effects of RPW irradiation on muscles, focusing on muscle morphology and muscle/fascial elasticity.

Methods: The participants were 23 healthy, able-bodied participants.

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Background: The common femoral artery is most frequently accessed for neuroendovascular procedures. Occasionally, postoperative hemostasis is difficult to attain. We comparatively analyzed the vascular closure devices, Angioseal and Perclose, and evaluated the puncture-site complications.

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Background: Foot strike patterns during running are typically categorized into two types: non-rearfoot strike (NRFS) and rearfoot strike (RFS), or as three distinct types: forefoot strike (FFS), midfoot strike (MFS), and RFS, based on which part of the foot lands first. Various methods, including two-dimensional (2D) visual-based methods and three-dimensional (3D) motion capture-based methods utilizing parameters such as the strike index (SI) or strike angle (SA), have been employed to assess these patterns. However, the consistency between the results obtained from each method remains debatable.

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Objective: Stent retriever (SR) angioplasty is an adjunctive technique for acute large vessel occlusion stroke due to underlying intracranial atherosclerotic disease (ICAD-LVO). Prolonged SR deployment maintains blood flow distal to the atherosclerotic lesion until the antiplatelet agent has exerted its effect. Although SR angioplasty for ICAD-LVO has been reported, few reports are available on SR angioplasty for medium vessel occlusion stroke due to underlying ICAD (ICAD-MeVO).

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This study aimed to evaluate developmental patterns in athletic performance during youth and determine their association with changes in physical fitness. The testing included three athletic performance (i.e.

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Article Synopsis
  • Calcaneal apophysitis is a common cause of heel pain in children and adolescents, but its connection to skeletal maturity in youth baseball players is not well understood.
  • The study involved 336 male youth baseball players, assessing the maturity of the calcaneal apophysis through ultrasound and classifying it into five stages, while diagnosing heel pain through subjective reports.
  • Results showed a 14.6% prevalence of heel pain among the players, but no significant relationship existed between the maturity stages of the calcaneal apophysis and the experience of heel pain, with no cases reported at the final maturation stage.
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  • - The study investigates how physical characteristics related to growth in adolescents affect throwing mechanics and the risk of elbow injuries in baseball players by examining forearm-hand inertia and elbow valgus load.
  • - 35 adolescent baseball players participated, with their throwing performance and mechanics analyzed using x-ray scans and motion sensors, allowing for comparisons between two distinct throwing patterns: proximal-to-distal sequencing (PDS) and proximal upper extremity (PUE).
  • - Results showed that the PUE group had greater elbow valgus load, throwing efficiency, and forearm-hand inertia compared to the PDS group, highlighting the significant relationship between throwing motion patterns and forearm-hand inertia.
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Background: The purpose of this study was to clarify the differences in the movement of the superficial microchambers and deep macrochambers of the heel fat pad during loading and unloading movements, and to clarify the influence of height and weight on this movement.

Methods: The subjects were 21 healthy adults. The right foot was placed on an evaluation instrument stand made of polymethylpentene (PMP) resin plate, and the left foot was placed on a scale stand used to adjust the amount of load.

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Objective: Flow diverters (FDs), first introduced in Japan in 2015, were initially limited to wide-necked large cerebral aneurysms, which pose a high treatment risk. However, based on the results of the PREMIER study, the indications have expanded since 2020, and the number of treatment cases is increasing in Japan. At our hospital, FD placement with adjunctive coil embolization has been actively performed for medium-sized cerebral aneurysms, as indicated in the PREMIER study; herein, we report the outcomes of this treatment.

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Objective: This study aimed to investigate the performance of generative pre-trained transformer-4 (GPT-4) on the Certification Test for Mental Health Management and whether tuned prompts could improve its performance.

Methods: This study used a 3 × 2 factorial design to examine the performance according to test difficulty (courses) and prompt conditions. We prepared 200 multiple-choice questions (600 questions overall) for each course using the Certification Test for Mental Health Management (levels I-III) and essay questions from the level I test for the previous four examinations.

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Desmoplakin (Dsp) is a component of desmosomal cell-cell junctions that interacts with the cadherin complex and cytoskeletal intermediate filaments. In addition to its function as an adhesion component, Dsp is involved in various biological processes, such as gene expression, differentiation, and migration. Dsp is specifically expressed in the hippocampal dentate gyrus (DG) in the central nervous system.

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Article Synopsis
  • * Findings showed that male runners with low BMD trained more hours and had less varied physical activity compared to those with normal BMD, while female runners with low BMD engaged in more varied activities in middle school but had similar running volumes.
  • * The study suggests that to reduce the risk of low BMD, young runners should mix in various sports, avoid focusing too much on long-distance running, and prevent excessive training during their growth phases.
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  • Elevated serum alkaline phosphatase (ALP) levels in hemodialysis patients can indicate a higher risk of mortality, with traditional measurements in Japan (JSCC method) yielding significantly higher ALP values than the more sensitive IFCC method.
  • A study comparing ALP levels before and after switching from JSCC to IFCC showed that patients with blood types B and O consistently had higher ALP readings, regardless of the method used.
  • The highest ALP tertile was linked to greater all-cause mortality risk, but this association weakened when liver function and inflammation markers were considered, suggesting that elevated ALP levels should be interpreted cautiously, especially in certain patient subgroups.
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Introduction: NSCLC is a leading cause of cancer-related mortality worldwide. Specific genetic alterations, such as exon 14 (ex14) skipping, have been identified in NSCLC, allowing targeted therapy. Tepotinib, a highly selective MET inhibitor, has displayed promise in patients with advanced NSCLC.

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  • Companion diagnostic (CDx) tests are crucial for identifying genetic mutations in lung cancer that can help tailor specific therapies for patients.
  • In Japan, the Oncomine Dx target test (ODxTT) and the AmoyDx pan lung cancer PCR panel have different methods and target regions, leading to potential missing of important mutations.
  • A comparison of 1059 genetic alterations revealed a high agreement (97.6%) between the two tests, but also identified undetected and false-positive results, underscoring the need for careful selection of diagnostic tests in precision medicine.
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Background: This study aimed to investigate the thickness changes of the heel fat pad and the plantar fascia associated with loading and unloading in healthy individuals and patients with heel pain and reveal the differences between them.

Methods: The study included adult male participants with (n = 9) and without (n = 26) heel pain. The participants placed their right foot on an evaluation apparatus with a polymethylpentene resin board (PMP), while their left foot was positioned on a weighing scale used to adjust the loading weight.

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Background: Differences in the physical characteristics of bilateral and unilateral lumbar bone stress injuries (BSIs) are unknown.

Purpose: To compare bilateral and unilateral lumbar BSIs in adolescent male soccer players, with a focus on lumbopelvic alignment.

Study Design: Cross-sectional study; Level of evidence, 3.

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Objective: The maintenance dose of prasugrel (PRAS) for neuroendovascular treatment requires much research. We report the antiplatelet effect of PRAS measured by VerifyNow P2Y12 reaction units (PRUs) in patients during the perioperative period of neuroendovascular treatment.

Methods: Between January 2017 and January 2023, 230 patients who underwent endovascular treatment for unruptured intracranial aneurysms or carotid artery stenosis at our institution were retrospectively identified.

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  • Osteoclastogenesis is the process of developing special cells called osteoclasts that help break down bone, and metal ions are important for this process.
  • * Metallothionein (MT) is a protein that helps control metal levels in the body and its role in osteoclast formation, particularly MT3, is essential for their development.
  • * When scientists reduced the amount of MT3 in certain cells, it stopped them from becoming mature osteoclasts and affected other important processes like cell survival and the balance of harmful molecules called reactive oxygen species (ROS).
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Background: Identifying the characteristics of batting mechanics, such as the proper angle and position of each body segment in youth baseball players, is important for proper instructions. This study aimed to identify the age-related changes in batting kinematics including rotational and separational movements of the head, upper trunk, pelvis, and arms, in youth baseball players.

Methods: Over the three seasons, we measured the batting motion of baseball players aged 6- to 12 years using three high-speed cameras.

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This study proposed a numerical method of dynamic mode decomposition with memory (DMDm) to analyze multidimensional time-series data with memory effects. The memory effect is a widely observed phenomenon in physics and engineering and is considered to be the result of interactions between the system and environment. Dynamic mode decomposition (DMD) is a linear operation-based, data-driven method for multidimensional time-series data proposed in 2008.

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