Expression of the Ets-1 proto-oncogene is linked to cell differentiation of human hepatocellular carcinoma.

Background/aims: Ets-1 regulates the expression of a number of genes related to remodeling of the extracellular matrix. Ets-1 is associated with the occurrence of invasive processes, proliferation and differentiation. Less is known about the biological functions of Ets-1 in human hepatocellular carcinoma.