Publications by authors named "Tsutomu Sudo"
Article Synopsis
- An increase in myeloid cells is a key feature of severe COVID-19, but previous research focused mainly on Europe, where the mortality rates are higher compared to Japan.
- A study of blood samples from Japanese COVID-19 patients showed that polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) increased in severe cases but not in milder cases, and this expansion was seen in survivors but not in those who did not survive.
- The findings suggest that the presence of PMN-MDSCs correlates with higher levels of IL-8 and is linked to better clinical outcomes, indicating that this cell type may serve as a potential predictor for recovery in severe COVID-19 patients in Japan.
Objectives: Rapid antigen testing (RAT) for coronavirus disease 2019 (COVID-19) has lower sensitivity but high accuracy during the early stage when compared to reverse transcription quantitative polymerase chain reaction (RT-qPCR). The aim of this study was to investigate the concordance between RAT and RT-qPCR results, and their prediction of disease transmission.
Methods: This single-center retrospective observational study of inpatients with COVID-19 was conducted from March 6 to June 14, 2020.