Publications by authors named "Tsutomu Omori"
The tumor-elicited inflammation is closely related to tumor microenvironment during tumor progression. S100A8, an endogenous ligand of Toll-like receptor 4 (TLR4), is known as a key molecule in the tumor microenvironment and premetastatic niche formation. We firstly generated a novel multivalent S100A8 competitive inhibitory peptide (divalent peptide3A5) against TLR4/MD-2, using the alanine scanning.
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- Emerging research shows that neural activity plays a role in tumor initiation and spread, particularly through the sympathetic nervous system (SNS).
- The SNS is known to influence tumor growth and angiogenesis, but its effects in pre-metastatic environments are not well understood.
- A study using a chemical method to disrupt the SNS in mice demonstrated reduced lung metastasis, suggesting that the SNS helps prepare distant sites for tumor spread through interactions with immune cells.
Accumulating evidence indicates that an elevated ephrin-A1 expression is positively correlated with a worse prognosis in some cancers such as colon and liver cancer. The detailed mechanism of an elevated ephrin-A1 expression in a worse prognosis still remains to be fully elucidated. We previously reported that ADAM12-cleaved ephrin-A1 enhanced lung vascular permeability and thereby induced lung metastasis.
View Article and Find Full Text PDFPrimary tumours establish metastases by interfering with distinct organs. In pre-metastatic organs, a tumour-friendly microenvironment supports metastatic cells and is prepared by many factors including tissue resident cells, bone marrow-derived cells and abundant fibrinogen depositions. However, other components are unclear.
View Article and Find Full Text PDFEphrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 4.
Biochem Biophys Res Commun
November 2013
The deregulation of Eph/ephrin protein expression has been shown to lead to tumor development and progression. Both mRNA and protein expression analyses using clinical samples have demonstrated that ephrin-A1 is over-expressed in various cancers and positively correlates with a poor prognosis for cancer patients. The prognosis of cancer patients depends on metastasis to distant organs.
View Article and Find Full Text PDFSerum amyloid A (SAA) 3 is a major component of the acute phase of inflammation. We previously reported that SAA3 served as an endogenous peptide ligand for TLR4 to facilitate lung metastasis. Because these experiments were performed with SAA3 recombinant proteins purified from Escherichia coli or mammalian cells, we could not rule out the possibility of LPS contamination.
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- - The Eph-ephrin receptor-ligand system, particularly EphA1, plays a crucial role in controlling cell behavior and shape, although its functions have been poorly understood until now.
- - Research findings reveal that activating EphA1 kinase can inhibit cell spreading and movement via the RhoA-ROCK signaling pathway and identify a significant interaction between EphA1 and integrin-linked kinase (ILK).
- - The interaction between EphA1 and ILK is essential for regulating these processes and operates independently of EphA1's kinase activity, suggesting that EphA1 influences cell structure and movement by modulating the ILK and RhoA pathways.