[A Patient with Endometrial Cancer Safely Administered Pembrolizumab Through a Pharmaceutical Outpatient Service].

Pharmaceutical outpatient clinics provide guidance for the initiation of cancer pharmacotherapy and, importantly, propose drugs for supportive care, evaluate side effects, and improve adherence to oral anticancer drugs. Our hospital established a pharmaceutical outpatient clinic for the early detection of immune-related adverse events and safe continual administration of immune checkpoint inhibitors. A 56-year-old woman received 11 cycles of paclitaxel/carboplatin therapy for FIGO Stage Ⅰb endometrial cancer.

Longitudinal assessment of anti-Müllerian hormone after cesarean section and influence of bilateral salpingectomy on ovarian reserve.

Objective: This study aimed to compare longitudinal changes in ovarian reserve markers after cesarean section (CS) with and without bilateral salpingectomy (BS).

Study Design: We prospectively enrolled women >35 weeks' gestation scheduled for CS alone or CS + BS and obtained blood samples for anti-Müllerian hormone prior to surgery and at 3 and 6 months after surgery. At the 3-month visit, we similarly performed transvaginal ultrasound for antral follicle count.

Patients' need for information on permanent contraception during a cesarean section: A cross-sectional questionnaire survey.

Aim: The present study aimed to explore the need for information about permanent contraception in Japanese women with repeated cesarean sections (CS).

Methods: The present, cross-sectional survey used a self-administered questionnaire mailed to women with a second or later CS at Tokyo Metropolitan Tama Medical Center between March 2010 and December 2017. Those who were pregnant, had given birth less than 1 year before the survey or had an hysterectomy were excluded.

Relationship between the precursors of high grade serous ovarian cancer and patient characteristics: decreased incidence of the p53 signature in pregnant women.

Objective: To investigate the relationship between the precursors of high grade serous ovarian cancer (HGSOC) and the characteristics of patients with a low HGSOC risk in terms of the effects of pregnancy.

Methods: We prospectively examined consecutive cases in which the bilateral fallopian tubes were removed during benign gynecological or obstetric surgery and assessed the relationship between the patient characteristics, including parity and pregnancy, and the incidence of HGSOC precursors. All the fallopian tubes were examined by applying the Sectioning and Extensively Examining the Fimbriated End (SEE-FIM) Protocol.

Management of labor and delivery in myasthenia gravis: A new protocol.

Aim: Pregnancy with myasthenia gravis (MG) is known to be associated with an increased cesarean section rate, presumably due to maternal fatigue during labor. Although epidural labor analgesia (ELA) appears to be a good option for circumventing maternal fatigue, a protocol for managing MG deliveries has not been established. This study, based on a review of our case series, aimed to evaluate the validity of our management protocol for maternal MG, in which ELA is used depending on MG severity.