Sulforaphane improves voiding function via the preserving mitochondrial function in diabetic rats.

Background: Hyperglycemia evoked oxidative stress contributing to diabetes (DM)-induced voiding dysfunction. We explored whether antioxidant sulforaphane,a NF-E2-related nuclear factor erythroid-2 (Nrf-2) activator, may ameliorate DM-induced bladder dysfunction.

Methods: DM was induced by streptozotocin and sulforaphanewas administered before DM induction.

Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis.

Aim:  Enhancement of thromboxane A (TXA) synthase (TXAS) activity, TXA release, and thromboxane prostanoid (TP) receptor activation leads to vasoconstriction and oxidative injury. We explored whether genetic deletion of TXAS/TXA/TP signalling may reduce renal ischaemia/reperfusion (I/R) injury in mice.

Materials And Methods:  Renal haemodynamics and function were evaluated in TXASTP (wild-type, WT), TXAS (TXS), TP and TXASTP (double knockout, dKO) mice in response to intravenous TXA mimetic-U46619 and 45-minute renal ischaemia and 4-hour reperfusion injury.

Monascus Adlay and Monacolin K Attenuates Arterial Thrombosis in Rats through the Inhibition of ICAM-1 and Oxidative Stress.

Background/aims: Monascus Adlay (MA) prepared from fungal fermentation of Monascus purpureus inoculating with cooked adlay contains high content of monakolin K (MK) and phenolic compounds. We explored whether MA and MK improve FeCl3-induced arterial thrombosis in rats.

Methods: The rats were divided into control, FeCl3-treated rat carotid artery occlusion (TTO), TTO determined with one-week MA, and TTO determined with one-week MK.