Incidence and Clinical Features of Postoperative Symptomatic Hematoma after Spine Surgery: A Multicenter Study of 45 Patients.

Introduction: Symptomatic postoperative hematoma after spine surgery is a rare but serious complication. The objective of this study was to investigate the incidence and clinical features of symptomatic postoperative hematoma after spine surgery.

Methods: We retrospectively identified 10,680 patients who underwent spine surgery between 2002 and 2012 in nine hospitals.

Catastrophic Dropped Head Syndrome Requiring Multiple Reconstruction Surgeries after Cervical Laminoplasty.

Introduction: Dropped head syndrome (DHS) after cervical laminoplasty (LAMP) is a rare complication, and no etiologies or surgical strategies have been reported. We present a patient who developed catastrophic DHS after LAMP despite having preoperative cervical lordosis that is known to be suitable for LAMP. We describe a hypothesis concerning the possible mechanism responsible for the DHS and a surgical strategy for relieving it.

Pedicle Screw Fluid Sign: An Indication on Magnetic Resonance Imaging of a Deep Infection After Posterior Spinal Instrumentation.

Study Design: A single-center case-referent study.

Objective: To assess whether the "pedicle screw (PS) fluid sign" on magnetic resonance imaging (MRI) can be used to diagnose deep surgical site infection (SSI) after posterior spinal instrumentation (PSI).

Summary Of Background Data: MRI is a useful tool for the early diagnosis of a deep SSI.

Surgical results and complications of anterior decompression and fusion as a revision surgery after initial posterior surgery for cervical myelopathy due to ossification of the posterior longitudinal ligament.

OBJECTIVE Ossification of the posterior longitudinal ligament (OPLL) is a progressive disease. An anterior cervical decompression and fusion (ACDF) procedure for cervical OPLL is theoretically feasible, as the lesion exists anteriorly; however, such a procedure is considered technically demanding and is associated with serious complications. Cervical laminoplasty is reportedly an effective alternative procedure with few complications; it is recognized as a comparatively safe procedure, and has been widely used as an initial surgery for cervical OPLL.

A multi-center study of reoperations within 30 days of spine surgery.

Purpose: To investigate the incidence and causes of reoperations within 30 days of spine surgery.

Methods: Patients who underwent spine surgery between 2002 and 2012, at one of 9 institutions, were enrolled. The causes of all reoperations, within 30 days of the index surgery, were reviewed.

Anterior corpectomy and fusion to C2 for cervical myelopathy: clinical results and complications.

Purpose: Anterior cervical corpectomy and fusion (ACCF) to C2 (ACCF-C2) for multilevel lesions is a challenging procedure that is indicated for massive ossification of the posterior longitudinal ligament (OPLL) extending to C2 or stenosis at the upper cervical region accompanied by kyphosis. However, there is little information on the effectiveness of and complications related to ACCF-C2. The purpose of this study was to investigate the overall surgical results and postoperative complications of ACCF-C2 for cervical myelopathy.

Extremely wide and asymmetric anterior decompression causes postoperative C5 palsy: an analysis of 32 patients with postoperative C5 palsy after anterior cervical decompression and fusion.

Study Design: Single-center retrospective study.

Objective: We examined whether extremely wide and asymmetric anterior decompression causes postoperative C5 palsy.

Summary Of Background Data: Postoperative C5 palsy is a complication of cervical decompression surgery.

Sacral fracture after instrumented lumbosacral fusion: analysis of risk factors from spinopelvic parameters.

Study Design: Retrospective comparative study.

Objective: To examine the incidence and characteristics of key spinopelvic parameters that are correlated with sacral fracture development after lumbosacral fusion.

Summary Of Background Data: Sacral fracture is a possible complication of instrumented lumbosacral fusion and this has recently been documented in the literature.

Hybrid Decompression and Fixation Technique Versus Plated 3-Vertebra Corpectomy for 4-Segment Cervical Myelopathy: Analysis of 81 Cases With a Minimum 2-Year Follow-Up.

Study Design: A retrospective comparative study.

Objective: The purpose of this study was to compare the stability and outcomes of a hybrid technique with those of a 3-vertebra corpectomy in the management of 4-segment cervical myelopathy.

Summary Of Background Data: Patients with primarily ventral disease and loss of cervical lordosis are considered good candidates for anterior surgery.

Progressive thoracic myelopathy caused by spinal calcium pyrophosphate crystal deposition because of proximal junctional vertebral compression fracture after lumbopelvic fusion.

Purpose: We describe cases presenting with progressive thoracic myelopathy after lumbopelvic fusion attributed to proximal junctional vertebral compression fracture (PJF) followed by spinal calcium pyrophosphate dehydrate (CPPD) crystal deposition.

Methods: The study included six patients, ranging from 62 to 75 years. All patients had been treated previously with lumbopelvic fusion.

Risk factors for cage retropulsion after posterior lumbar interbody fusion: analysis of 1070 cases.

Study Design: Single-center retrospective study.

Objective: We examined the risk factors for cage retropulsion after posterior lumbar interbody fusion (PLIF) performed for patients with degenerative lumbar spinal diseases.

Summary Of Background Data: Although PLIF is a widely accepted procedure, problems remain regarding perioperative and postoperative complications.

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25.

Sox9 is a direct transcriptional activator of cartilage-specific extracellular matrix genes and has essential roles in chondrogenesis. Mutations in or around the SOX9 gene cause campomelic dysplasia or Pierre Robin Sequence. However, Sox9-dependent transcriptional control in chondrogenesis remains largely unknown.

A novel technique for impaction bone grafting in acetabular reconstruction of revision total hip arthroplasty using an ex vivo compaction device.

Background: Impaction bone grafting allows restoration of the acetabular bone stock in revision hip arthroplasty. The success of this technique depends largely on achieving adequate initial stability of the component. To obtain well-compacted, well-graded allograft aggregates, we developed an ex vivo compaction device to apply it in revision total hip arthroplasty on the acetabular side, and characterized mechanical properties and putative osteoconductivity of allograft aggregates.

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine.

The liver and exocrine pancreas share a common structure, with functioning units (hepatic plates and pancreatic acini) connected to the ductal tree. Here we show that Sox9 is expressed throughout the biliary and pancreatic ductal epithelia, which are connected to the intestinal stem-cell zone. Cre-based lineage tracing showed that adult intestinal cells, hepatocytes and pancreatic acinar cells are supplied physiologically from Sox9-expressing progenitors.

Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons.

Sox9 expression defines cell progenitors in a variety of tissues during mouse embryogenesis. To establish a genetic tool for cell-lineage tracing and gene-function analysis, we generated mice in which the CreERT2 gene was targeted to the endogenous mouse Sox9 locus. In Sox9(CreERT2/+) ;R26R embryos, tamoxifen activated Cre recombinase exclusively in Sox9-expressing tissues.