Publications by authors named "Tsunekazu Hanai"
Background: The da Vinci™ Surgical System, recognized as the leading surgical robotic platform globally, now faces competition from a growing number of new robotic surgical systems. With the expiration of key patents, innovative entrants have emerged, each offering unique features to address limitations and challenges in minimally invasive surgery. The hinotori™ Surgical Robot System (hinotori), developed in Japan and approved for clinical use in November 2022, represents one such entrant.
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- - The study aimed to assess the effectiveness of duodenum-preserving pancreatic head resection (DPPHR) as a treatment for pancreatic neuroendocrine tumors (PNETs) in relation to curability and patient quality of life post-surgery.
- - Seven patients underwent DPPHR between January 2011 and December 2021, with the procedure showing manageable postoperative complications and achieving complete curative resections without positive tumor margins.
- - The findings suggest that DPPHR is a viable alternative to more invasive surgeries like pancreaticoduodenectomy for treating PNETs, allowing for thorough pathological assessment while minimizing patient recovery concerns.
Article Synopsis
- The study investigates the differences in histological features between colitis-associated intestinal cancer (CAC) and sporadic colorectal cancer (CRC) in patients with inflammatory bowel disease.
- Data from a national database in Japan covering over 36 years was used to analyze 1,077 cases of ulcerative colitis-related CAC and 297 cases related to Crohn’s disease, alongside a large cohort of sporadic CRC patients.
- Findings reveal that CAC exhibits a higher prevalence of aggressive cancer types compared to sporadic CRC, with this difference becoming more prominent as the tumors progress.
Article Synopsis
- - A patient with sigmoid colon cancer and multiple liver metastases achieved complete remission after chemotherapy and a hepatectomy, but later experienced local recurrence and underwent a second surgery.
- - Following laparoscopic sigmoidectomy for a new adenocarcinoma diagnosed via colonoscopy, the patient received further chemotherapy which resulted in the liver metastases shrinking, allowing for a successful right hepatectomy.
- - Despite the initial success, a follow-up revealed local recurrence of liver metastasis, leading to a partial hepatectomy; the patient is currently recurrence-free and continuing treatment with modified FOLFOX.
Article Synopsis
- - A woman in her 70s with locally advanced unresectable pancreatic cancer received 5 courses of modified FOLFIRINOX chemotherapy followed by radiation therapy after being diagnosed with an irregular mass invading nearby arteries, classified as cStage Ⅲ cancer.
- - Her treatment resulted in a significant drop in CA19-9 levels, indicating a partial response to treatment, and led to the decision that her tumor was potentially curable.
- - Eight months after starting treatment, she underwent successful surgery (subtotal stomach-preserving pancreaticoduodenectomy) and was found to be cancer-free with no recurrence at 5 months post-operation.
Article Synopsis
- Colorectal cancer (CRC) presents a significant risk for patients with Crohn's disease (CD), and this study aimed to investigate the prognosis and characteristics of CD-related CRC (CD-CRC) compared to sporadic CRC using a large database of cases.
- The analysis included 233 CD-CRC patients and 129,783 sporadic CRC patients, revealing that CD-CRC patients were typically younger, more likely to have rectal cancer, multiple tumors, and a distinct type of cancer called mucinous adenocarcinoma, all resulting in lower survival rates.
- The findings showed a lower five-year overall survival rate for CD-CRC (53.99% vs. 71.17% for sporadic CRC
Introduction: The aim of this study was to evaluate the effect of biologics on the risk of advanced-stage inflammatory bowel disease (IBD)-associated intestinal cancer from a nationwide multicenter data set.
Methods: The medical records of patients with Crohn's disease (CD) and ulcerative colitis (UC) diagnosed with IBD-associated intestinal neoplasia (dysplasia or cancer) from 1983 to 2020 were included in this study. Therapeutic agents were classified into 3 types: biologics, 5-aminosalicylic acid, and immunomodulators.
Aim: In Japan, we have not been able to validate the results of laparoscopic surgery for locally advanced rectal cancer using the universal index "circumferential resection margin (CRM)." Previously, we established a semi-opened circular specimen processing method and validated its feasibility. In the PRODUCT trial, we aimed to assess CRM in patients with locally advanced rectal cancer who underwent laparoscopic rectal resection.
View Article and Find Full Text PDFThe outer mucus layer of the colorectal epithelium is easily removable and colonized by commensal microbiota, while the inner mucus layer is firmly attached to the epithelium and devoid of bacteria. Although the specific bacteria penetrating the inner mucus layer can contact epithelial cells and trigger cancer development, most studies ignore the degree of mucus adhesion at sampling. Therefore, we evaluated whether bacteria adhering to tissues could be identified by removing the outer mucus layer.
View Article and Find Full Text PDFBackground: Patients with longstanding inflammatory bowel disease are at high risk of developing intestinal cancers. In this study, we aimed to elucidate the differences between intestinal cancers associated with ulcerative colitis and Crohn's disease.
Methods: Intestinal cancers in ulcerative colitis and Crohn's disease patients treated between 1983 and 2020 at 43 Japanese institutions were retrospectively analyzed.
Purpose: To delineate the long-term results of minimally invasive transanal surgery (MITAS) for selected rectal tumors.
Methods: We analyzed data, retrospectively, on consecutive patients who underwent MITAS between 1995 and 2015, to establish the feasibility, excision quality, and perioperative and oncological outcomes of this procedure.
Results: MITAS was performed on 243 patients.
Objectives: To determine whether the tongue menthol test, which measures the cold sensation detection threshold (CDT) of the tongue, used before and after oxaliplatin administration is an objective evaluation method for oxaliplatin-induced peripheral neuropathy (OPN).
Methods: The tongue menthol test was administered to patients both before and after undergoing chemotherapy containing oxaliplatin for colorectal cancer. The tongue menthol test was conducted by applying a menthol solution (a selective agonist of transient receptor potential cation channel subfamily M member 8 [TRPM8]) to the tongue and measuring the CDT.
Objectives: Surgical site infection (SSI) is a problematic complication after stoma closure. The purse string suture (PSS) technique eliminates this problem, but the area takes longer to heal. The present retrospective study was performed to evaluate the usefulness of a vacuum-assisted closure (VAC) system for the promotion of wound healing after stoma closure.
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- The study assessed the effectiveness of robotic rectal surgery (RRS) using the double bipolar method (DBM) compared to the single bipolar method (SBM) in 157 patients treated by the same surgeon.
- Findings showed that the DBM resulted in significantly shorter console time for total mesorectal excision compared to the SBM, indicating a potential advantage in efficiency.
- Despite some limitations, the DBM proved to be a safe and viable option for patients, even those with advanced conditions, although further research is needed to evaluate its cost-effectiveness.
Obesity has been considered a risk factor for postoperative complications following colorectal cancer surgery. However, the usefulness of a combination of intracorporeal anastomosis and preoperative weight reduction for severely obese patients with colon cancer remains unclear. A 66-year-old man with a body mass index (BMI) of 43 kg/m presented with abdominal pain and iron deficiency anemia.
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- The text discusses corrections made to a previously published article identified by its DOI.
- The focus is on ensuring the accuracy and reliability of the research findings reported in that article.
- These corrections are important for maintaining the integrity of academic publishing and supporting future research in the field.
Objectives: This study aimed to elucidate the actual state of anal incontinence (AI), fecal incontinence (FI), and the associated factors in Japanese medical personnel.
Methods: A questionnaire was completed by Japanese medical personnel after listening to lectures on AI. AI was defined as involuntary loss of feces or flatus.
Article Synopsis
- This study investigates bowel habits and changes in bowel movements related to the menstrual cycle among Japanese medical personnel.
- Survey responses from 463 participants revealed that constipation is more prevalent in females (31%) compared to males (3%), especially increasing with age, while diarrhea is less common in females (7% vs. 1%).
- Notably, 61% of females reported changes in bowel movements during menstruation, with constipation occurring before and diarrhea during their menstrual periods; only a small percentage (5%) had difficulty using traditional Japanese toilets.
Objectives: To clarify the long-term outcomes of transvaginal anterior levatorplasty with posterior colporrhaphy for symptomatic rectocele with defecographic changes.
Methods: Consecutive patients undergoing transvaginal anterior levatorplasty with posterior colporrhaphy for symptomatic rectocele were prospectively registered and retrospectively reviewed using medical records. Symptoms, fecal incontinence, and defecographic findings were evaluated before and after surgery.
Background: Colorectal anastomosis using the double stapling technique (DST) has become a standard procedure. However, DST is difficult to perform in patients with anal stenosis because a circular stapler cannot be inserted into the rectum through the anus. Thus, an alternative procedure is required for colorectal anastomosis.
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- Enteroceles and rectoceles are types of pelvic organ prolapses that can cause vaginal masses and pelvic discomfort.
- Many patients have both conditions, yet there are limited reports on how to treat them simultaneously.
- A new procedure combines the repair of an enterocele with a rectocele repair using transvaginal techniques, which involves surgical alterations to provide better support to the pelvic structure.
Purpose: The published data on the outcomes of an operative repair for stoma prolapse are limited. This study aimed to clarify the long-term outcomes of stapler repair with anastomosis for stoma prolapse.
Methods: Twenty-four patients (15 men, median age 64 years, range 33-88 years) undergoing 25 stapler repairs with anastomosis were prospectively registered, and their medical records were retrospectively reviewed.