Publications by authors named "Tsunehiko Kuzuya"

We characterized the time course of the left ventricular (LV) geometric and functional changes after aortic banding, validated them by necropsy, and investigated the sensitivity of echocardiographic findings on LV hypertrophy. C57BL/6 mice were subjected to transverse aortic constriction (TAC) or sham operation; echocardiographic assessments were performed before or at 2, 4, 6, and 11 wk after surgery; and some of the mice were euthanized at the corresponding time points. There was a progressive increase in diastolic posterior wall thickness and LV systolic dimension; the percentage of LV fractional shortening (LV%FS) decreased progressively at 4 wk, whereas these parameters remained stable in sham-operated mice.

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Article Synopsis
  • Leg venous pressure significantly decreases during upright exercise due to the muscle pump, resulting in increased perfusion pressure and enhanced femoral artery blood flow (FABF).
  • In a study comparing 10 healthy individuals to 10 chronic heart failure (CHF) patients during upright cycling, normal subjects showed a dramatic decrease in mean ankle vein pressure (MAVP) and a 5.3-fold increase in FABF without systemic blood pressure changes.
  • In contrast, CHF patients experienced a smaller decline in MAVP and only a 1.7-fold increase in FABF, indicating that the muscle venous pump mechanism is less effective in those with CHF.
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Objective: This study attempted to establish echocardiographic measurements of left ventricular (LV) mass and LV systolic and diastolic function, particularly in rats with hypertensive heart.

Methods: M-mode LV echograms and Doppler mitral flow were obtained in Dahl salt-sensitive rats placed on 0.3% or 8% sodium chloride diet.

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