Vaccine Breakthrough Infections Among Healthcare Workers in a COVID-19-Designated Tertiary Care Government Hospital in Sikkim.

Introduction Since the emergence of the coronavirus disease 2019 (COVID-19) virus at the beginning of 2020, the world has gone through various waves of pandemics. The health care workers (HCWs) or the COVID warriors as they were termed were the first line of defense against the virus. They were armed with personal protective equipment and prophylactic doses of the COVID-19 vaccine.

Thiamine Responsive Acute Infantile Encephalopathy.

This retrospective study was conducted to describe clinical and investigational findings and to determine the effect of thiamine treatment on mortality in patients admitted with acute non-infectious encephalopathy to a hospital in Sikkim between October 2019 and March 2021. Amongst 37 included patients the median age was 4 mo (IQR 3-5), 62.2% were males, 75% were exclusively breastfed infants, 67.

Impact of Malnutrition on the Outcome of Critically Ill Children.

Objective: To assess the impact of nutritional status on outcomes like mortality rate, length of mechanical ventilation and length of Pediatric Intensive Care Unit (PICU) stay, in critically ill children.

Methods: In this retrospective study conducted at a tertiary care center, records of 332 critically ill children between 1 mo to 15 y of age for whom anthropometric parameters were available were included. Anthropometric parameters for the study subjects were used to assess the nutritional status using the WHO growth charts as the reference.

Pulmonary alveolar proteinosis secondary to Pneumocystis jiroveci infection in an infant with common variable immunodeficiency.

The authors report an infant with common variable immunodeficiency (CVID) with Pneumocystis pneumonia who developed secondary pulmonary alveolar proteinosis (PAP). This is the youngest infant reported to develop PAP secondary to Pneumocystis infection in an immunocompromised state. He was effectively managed with anti-microbials, frequent lung toilet, optimized mechanical ventilation, and supportive care.

Abnormalities in glucose homeostasis in critically ill children.

Objectives: To study the prevalence of hyperglycemia (blood glucose >126 mg/dL [>7 mmol/L]) in critically ill children older than 1 month in the first week of PICU stay and to determine its effect on mortality, organ dysfunction, and the length of PICU stay. We also determined the prevalence of glucose variability and hypoglycemia and studied their effect on mortality and morbidity.

Design: Prospective, observational cohort study.

Day 1 blood glucose and outcome in critically ill children.

We analyzed the association between the day 1 glucose values in 209 children admitted to the PICU and the outcome (mortality). 58 (27.7%) children had hyperglycemia while 18 (8.