[Immunocytochemical detection of antigen associated with squamous cell cancer of the cervix uteri in women].

Cervical preparations from 89 women were studied for antigen associated with squamous-cell cervical cancer (SCCC) by the indirect immunofluorescence method. The antigen was revealed specifically in 77.8% of samples of SCCC (stages Ib, II and III) in 64.

[Treatment of patients with 1B-stage cervical cancer].

An analysis of a more than 40-year experience of management of stage Ib, T1bN0M0 cervical cancer (611 cases) followed the development of combined treatment of the disease: Until 1970-ies, irradiation plus surgery was preferred. During the seventies no correlation between effectiveness and sequence of these component procedures was established. According to data on 33 surgical cases, extended extirpation of the uterus may be recommended in patients with stage Ib cervical cancer less than 5 mm deep and free from such adverse prognostic factors as concomitant pregnancy, poor cell differentiation and blood and lymph vascular microembolism by tumor.

[Evaluation of the principles of distribution of electrocardiographic R-R intervals for elaboration of methods of automated diagnosis of cardiac rhythm disorders].

A statistical analysis of prolonged ECG records has been carried out in patients with various heart rhythm and conductivity disorders. The distribution of absolute R-R duration values and relationships between adjacent intervals have been examined. A two-step algorithm has been constructed that excludes anomalous and "suspicious" intervals from a sample of consecutively recorded R-R intervals, until only the intervals between contractions of veritably sinus origin remain in the sample.

[Morphophysiological aspects of closed destruction of the conduction pathways of the heart].

An experimental study in an electrophysiological model of the human body showed defibrillator discharge current, used for closed electrodestruction of His' bundle in cases of drug-resistant supraventricular tachycardias, to cause a spark discharge and high-energy shock wave around the intracardiac electrode resulting in contusion of the heart. To stop the sparking, it is suggested that impulse voltage should be reduced while its duration should be prolonged in order to maintain local destruction potential. The relationship between the damaging effect of the impulse, and its force and duration was examined so that optimum action parameters could be established.

[A tumor-associated antigen of cervical cancer].

The tumour-associated antigen was identified with the aid of antisera obtained from rabbits immunized with 3 M KCl extract of pool human cervical carcinoma cells. The antigen was found in 92.5% specimens of human cervical squamous cell carcinoma, in 4.

Non-dipole components of the heart electrical field in electrocardiographic diagnosis of combined ventricular hypertrophy.

A new method of ECG diagnosis, based on a mathematical model of electrical heart generator as a mobile dipole, was clinically verified in 10 healthy subjects and 2 patients with combined cardiopathy and pronounced bilateral ventricular hypertrophy. Electrocardiograms were recorded in 80 unipolar leads from the body surface; recordings were processed by a computer. The output information were the pathways of the heart electrical centre (dipole) during the heart cycle.

[Possibilities in the conservative treatment of patients with early forms of uterine cancer].

Organ-saving surgery was used in 134 patients with early cervical cancer (high amputation with a lancet-98 and cryotherapy-36 cases). The efficiency of the procedure was verified by morphological examination of samples obtained from the operation site at certain periods after primary treatment. The results of surgical treatment and hormonotherapy of early endometrial cancer (66 and 17 cases, respectively) are presented.

[Automatic recognition of RR-intervals of sinus origin from real electrocardiographic signals].

A simple decisive rule for classifying RR-intervals of electrocardiograms by two types, sinusoidal and anomalous, is deduced using the theory of pattern recognition. Parameters of the decisive rule according to the minimum of the Buyess probability of the classification error are selected. The algorithm may be realized with microprocessors and used in cardiac rhythm monitors.

Mobile equivalent heart generator (migrating dipole).

The study is concerned with quantitative mapping of electrocardiographic potentials on the human body surface at various applications of equivalent multipole heart generators. The accuracy or reproduction of the electrical heart field with the application of mobile and immobile dipole and quadrupole generators is compared. The immobile equivalent generator (EG) is fixed in the geometrical centre of the trunk, whereas the mobile EG follows the path of the electrical heart centre during the heart cycle.

[Variability of sinus rhythm during deep respiration].

A possibility was studied of applying the deep and infrequent respiration test with an object of increasing the informativeness of the statistical parameters of the ECG sequence interval as applicable to the quantitative evaluation of the functional state of man. Examination of patients with wound infection shown that the deep respiration test makes in possible to assess quantitatively the status of test subjects on the basis of two statistical parameters (the mean value of RR interval of ECG and root-mean-square deviation).

[Heart-body biophysical model].

A biophysical model heart--body designed for experimental electrocardiographic investigations is described. The model consists of an isolated perfused dog heart immersed in a liquid volumetrical conductor filling the vessel in the form of a human torso with implanted electrodes for various ECG leads. The volumetrical conductor presents a hypotonic NaCl solution.

[Significance of the statistical characteristics of the sinus rhythm of the heart].

Statistical analysis of prolonged continuous recordings of the ECG RR intervals was carried out in 64 patients with purulent surgical infection. The following indices were considered: the mean value of the RR intervals, the mean quadratic deviation (delta), the variation amplitude, the 1st and the 3rd correlation coefficients, the excess, asymmetry, the RR/delta ratio. Besides, the size and the shape of the autoregression could was analyzed.

[Study of a multifield equivalent cardiac generator].

The electric field of the isolated dog heart immersed into a liquid volumetric conductor was subjected to a thorough investigation. Measurements and subsequent calculations showed that in precordial leads the quantitative description of the cardiac generator by a multipole equivalent generator of the 1st order (dipole) is rough approximation. Addition of a multipole component of the 2nd order (quadripole) to the equivalent generator increases but relatively little the accuracy of description.

[Measurement of the electric field of the heart in a homogeneous volume conductor].

The paper describes a technique and some results of experimental measurements of electrical potentials generated by an isolated dog heart in homogeneous conductor, drawing equipotential maps of the field, and calculating the characteristics of the dipole equivalent generator of the heart. The form of potential distribution on a spherical surface around the heart and its ideal orthogonal vectorcardiograms are discussed.

[Distribution of the density of defibrillating current in the chest and underneath the defibrillator's electrodes].

Results of experiments carried out in animals and of measurements made on electrophysical and analogue models are presented. It has been found that with routinely employed manipulations in the electric impulse therapy of arrhythmias the denstiy of the current in the chest and directly underneath the defibrillator's electrodes is distributed in a non-uniform fashion. This results in high defibrillation thresholds, possible damages of the heart and body teguments.