Aberrant sense of agency induced by delayed prediction signals in schizophrenia: a computational modeling study.

Aberrant sense of agency (SoA, a feeling of control over one's own actions and their subsequent events) has been considered key to understanding the pathology of schizophrenia. Behavioral studies have demonstrated that a bidirectional (i.e.

Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders.

Human genetics strongly support the involvement of synaptopathy in psychiatric disorders. However, trans-scale causality linking synapse pathology to behavioral changes is lacking. To address this question, we examined the effects of synaptic inputs on dendrites, cells, and behaviors of mice with knockdown of SETD1A and DISC1, which are validated animal models of schizophrenia.

Computational Psychiatry Research Map (CPSYMAP): A New Database for Visualizing Research Papers.

The field of computational psychiatry is growing in prominence along with recent advances in computational neuroscience, machine learning, and the cumulative scientific understanding of psychiatric disorders. Computational approaches based on cutting-edge technologies and high-dimensional data are expected to provide an understanding of psychiatric disorders with integrating the notions of psychology and neuroscience, and to contribute to clinical practices. However, the multidisciplinary nature of this field seems to limit the development of computational psychiatry studies.

[Simulation of Schizophrenia].

There have been so many and various researches of schizophrenia since the early days of modern psychiatry, but the pathology remains unexplained, and the treatmens not established. One of the reasons is the complexity of a brain which makes it difficult to form a bridge between biological findings and symptoms. Computational psychiatry has been recently expected to overcome this difficulty.

Dysconnectivity of the Agency Network in Schizophrenia: A Functional Magnetic Resonance Imaging Study.

Self-disturbances in schizophrenia have recently been explained by an abnormality in the sense of agency (SoA). The cerebral structures of SoA in healthy people are considered to mainly include the insula and inferior parietal lobule. In contrast, the functional lesion of aberrant SoA in schizophrenia is not yet fully understood.

Predicting anxiety state using smartphone-based passive sensing.

This study predicts the change of stress levels using real-world and online behavioral features extracted from smartphone log information. Previous studies of stress detection using smartphone data focused on a single feature and did not consider all features simultaneously. We propose a method to extract a co-occurring combination of a user's real-world and online behavioral features by converting raw sensor data into categorical features.

Behavioral evidence of delayed prediction signals during agency attribution in patients with schizophrenia.

Self-disturbance, a core feature of schizophrenia, recently has been explained from the standpoint of an abnormal sense of agency (SoA). Previous studies showed that aberrant SoA in schizophrenia arise from imprecise predictions about the sensory consequences of actions. However, the nature of the malfunctioning predictions remains unclear.

Reduced sense of agency in chronic schizophrenia with predominant negative symptoms.

Self-disturbances in schizophrenia have been regarded as a fundamental vulnerability marker for this disease, and have begun to be studied from the standpoint of an abnormal "sense of agency (SoA)" in cognitive neuroscience. To clarify the nature of aberrant SoA in schizophrenia, it needs to be investigated in various clinical subtypes and stages. The residual type of chronic schizophrenia with predominant negative symptoms (NS) has never been investigated for SoA.

Reliability and diagnostic validity for schizophrenia of the Japanese version of the Bonn Scale for Assessment of Basic Symptoms (BSABS).

Schizophrenia is defined by operative diagnostic criteria in DSM-IV with some typical symptoms as hallucinations and duration of the disease. Huber focused on the subjective experience of patients and coined the term "basic symptoms" and created BSABS. Our study investigated the reliability and the diagnostic validity of the 5 clusters of BSABS for DSM-IV-based diagnosis of schizophrenia with a cohort of 105 patients.