Prognostic significance of tumor necrosis factor receptor in colorectal adenocarcinoma.

Background: The expression pattern and prognostic impact of tumor necrosis factor receptor type 1 (TNFR1) in colorectal cancers are not known.

Patients And Methods: Immunohistochemical evaluation of TNFR1, Ki-67 and apoptosis was performed on formalin-fixed, paraffin-embedded specimens from 56 curatively-resected Dukes' stage C-colorectal cancer patients.

Results: Thirty-seven (66%) cases had a high expression and 19 (34%) cases had a low expression of TNFR1.