ERBB4 mutations that disrupt the neuregulin-ErbB4 pathway cause amyotrophic lateral sclerosis type 19.

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by the degeneration of motor neurons and typically results in death within 3-5 years from onset. Familial ALS (FALS) comprises 5%-10% of ALS cases, and the identification of genes associated with FALS is indispensable to elucidating the molecular pathogenesis. We identified a Japanese family affected by late-onset, autosomal-dominant ALS in which mutations in genes known to be associated with FALS were excluded.

[Interpersonal intolerance of ambiguity, interpersonal life events, and mental health].

This study examined in the interpersonal context whether interactions of intolerance of ambiguity and positive as well as negative life events in a diathesis-stress model predicted changes in mental health. College students, 236 men and women, completed a questionnaire of Revised Interpersonal Intolerance of Ambiguity (IIAS-R), Stress Response, and Happiness scales. They completed one and a half months later another questionnaire of Interpersonal Life Event, Stress Response, and Happiness scales.

[Group reminiscence therapy for Japanese elderly community].

This study examined the effectiveness of group reminiscence therapy in a Japanese elderly community. The relationship between the effectiveness of reminiscence therapy and styles of daily reminiscence was also examined. Participants (Two men and 46 women, mean age = 81.