Platonin mitigates vascular hyporeactivity of thoracic aorta in septic rats.

Background: Vascular hyporeactivity contributes to hemodynamic alterations and circulatory failure in severe sepsis. Among the identified mechanisms, inflammation and oxidative stress are the most crucial ones in mediating the development of vascular hyporeactivity induced by sepsis. Platonin, a photosensitive dye and an antioxidant, possesses potent antiinflammation effects.

Phosphoinositide 3-kinase/Akt pathway is involved in mediating the anti-inflammation effects of magnesium sulfate.

Background: We sought to elucidate whether enhancing phosphoinositide 3-kinase (PI3K)/Akt activity is a crucial mechanism underlying the anti-inflammation effects of magnesium sulfate (MgSO4).

Materials And Methods: Murine macrophages (RAW264.7 cells) were stimulated with endotoxin, endotoxin plus MgSO4, or endotoxin plus MgSO4 plus PI3K inhibitor (LY294002 or wortmannin).

High-lipid enteral nutrition could partially mitigate inflammation but not lung injury in hemorrhagic shock rats.

Background: Loss of gut barrier function is crucial in mediating lung injury induced by hemorrhagic shock/resuscitation (HS). High-lipid enteral nutrition (HL) can preserve gut barrier function. We hypothesized that HL could also mitigate HS-induced lung injury.

Heme oxygenase-1 mediates the protective effects of ischemic preconditioning on mitigating lung injury induced by lower limb ischemia-reperfusion in rats.

Background: Lower limb ischemia-reperfusion (I/R) imposes oxidative stress, elicits inflammatory response, and subsequently induces acute lung injury. Ischemic preconditioning (IP), a process of transient I/R, mitigates the acute lung injury induced by I/R. We sought to elucidate whether the protective effects of IP involve heme oxygenase-1 (HO-1).

Sudden hearing loss after general anesthesia--a case report.

Hearing impairment following many types of neuraxial anesthetic techniques has alreadly been reported previously. However, postoperative sudden hearing loss after general anesthesia (excluding cardiopulmonary bypass cases) for nonotologic surgery is rarely reported. We present a 42-year-old female patient, who underwent ophthalmologic surgery under general anesthesia because of diabetic retinopathy and developed postoperative hearing loss of the left ear.

Postpartum unilateral Horner's syndrome following lumbar epidural anesthesia after a Cesarean delivery.

We report on a case demonstrating unilateral Horner's syndrome (HS) after lumbar epidural obstetric anesthesia. A healthy, 32-year-old woman with a breech presentation was scheduled for an elective Cesarean section. The patient had normal vital signs throughout the surgical procedure.