Publications by authors named "Tsui J"
Macular hole formation is a rare complication of laser peripheral iridotomy (LPI) and may cause permanent scotomas. This case describes macular hole formation after 2.8 mJ Nd:YAG laser energy application in a patient with vitreomacular attachment.
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- Long-term androgen deprivation therapy in men with high-risk prostate cancer is linked to a decrease in bone mineral density, but this does not significantly increase the risk of fractures.
- A study analyzed the bone mineral density changes after 28 months of therapy and supplementation with calcium and vitamin D in patients, revealing an average decrease of -3.2% across multiple sites without significant classification changes for most patients.
- The findings suggest that while there is a slight reduction in bone mineral density, calcium and vitamin D supplementation is generally effective in managing bone health for these patients on long-term therapy.
Background: Hepatitis C and HIV are associated with opioid use disorders (OUD) and injection drug use. Medications for OUD can prevent the spread of HCV and HIV.
Objective: To describe the prevalence of documented OUD, as well as receipt of office-based medication treatment, among primary care patients with HCV or HIV.
Purpose: To describe eight patients with toxoplasma retinochoroiditis following exposure to wild game.
Methods: Retrospective, multicenter case series.
Results: Eight men, aged 29 to 71 (mean, 56 years), developed toxoplasmic retinochoroiditis after hunting and/or consuming wild game in the United States, including seven deer and one bear.
Persons with HIV (PWH) experience chronic pain and Post-Traumatic Stress Disorder (PTSD) at higher rates than the general population, and more often receive opioid medications to treat chronic pain. A known association exists between PTSD and substance use disorders, but less is known about the relationship between PTSD and risky opioid use among PWH taking prescribed opioid medications. In this observational study of PWH on long-term opioid medications for pain we examined associations between PTSD symptom severity based on the Post Traumatic Stress Disorder Checklist for DSM-5 (PCL-5, response range 0-80) and the following outcomes: 1) risk for opioid misuse (COMM score ≥13); 2) risky alcohol use (AUDIT score ≥8); 3) concurrent benzodiazepine prescription; and 4) morphine equivalent dose.
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- - The PROUD trial aims to test a collaborative care model in primary care settings to improve treatment access and outcomes for individuals with opioid use disorder (OUD), focusing on increasing medication days and reducing acute healthcare use.
- - The study involves a hybrid design in six healthcare systems, where two primary care clinics are randomized to either the intervention (with a nurse care manager and DEA-waivered providers) or usual care, targeting patients aged 16-90 over a span of five years.
- - Data collection combines quantitative measures from electronic health records and administrative data with qualitative insights from staff surveys and site observations to understand barriers and facilitators to the implementation of OUD treatment.
Article Synopsis
- The study explores the differences between mild and severe COVID-19 by analyzing immune cell responses in patients using a specialized blood analysis technique.
- It finds that patients with mild COVID-19 show a strong expression of interferon-stimulated genes (ISGs), while those with severe disease lack these ISG-expressing cells despite having high levels of anti-SARS-CoV-2 antibodies.
- The research suggests that severe cases may be counterproductive, as the antibodies produced can inhibit the immune response critical for fighting the virus, pointing to potential targets for new treatments.
Background: Direct acting antivirals (DAAs) have revolutionized management of hepatitis C virus (HCV), but treatment uptake remains low among persons who inject drugs (PWID). We report the continuum of care for HCV and describe predictors of treatment with DAAs among PWID in Seattle.
Methods: We analyzed data from the 2018 Seattle area National HIV Behavioral Surveillance (NHBS) survey of PWID.
Article Synopsis
- A group of teachers and healthcare workers created a program to help long-term care teams learn new skills to do their jobs better.
- They studied different ways to teach since the staff comes from many backgrounds and experiences.
- The results showed that the program was helpful, and they shared ideas on how to train workers in long-term care facilities (LTC) in the future.
HPV vaccination rates have improved in recent years, but remain suboptimal in the United States. Physician recommendation is associated with increased uptake; however, specific strategies used by physicians to recommend the vaccine and address hesitancy are underexplored. We iteratively conducted qualitative in-depth interviews with family medicine and pediatrics/adolescent medicine physicians recruited from four primary care settings (federally qualified health centers and hospital-affiliated practices) within a large academic-hospital system in New Jersey.
View Article and Find Full Text PDFMethod to Improve the Effectiveness of Community-Based Participatory Research Projects: A Social Network Approach.
Prog Community Health Partnersh
October 2021
Background: To successfully complete a community-based participatory research (CBPR) project, different types of relationships and different degrees of stakeholder investment are required, depending on context. We propose a method that will help assess relational connectivity and investment in many types of CBPR structures. Using data from a CBPR project, a network method is examined to test its effectiveness in identifying the CBPR project's strengths and weaknesses.
View Article and Find Full Text PDFPurpose: Diabetes and hypertension are two common comorbidities that affect breast cancer patients, particularly Black women. Disruption of chronic disease management during cancer treatment has been speculated. Therefore, this study examined the implementation of clinical practice guidelines and health outcomes for these comorbidities before and during cancer treatment.
View Article and Find Full Text PDFIntroduction: Electrocardiogram is the first-line diagnostic imaging modality for evaluating patients with chest pain. The present study aimed to determine the capability of emergency nurses for electrocardiogram interpretation by using a more appropriate questioning method.
Methods: This was a cross-sectional descriptive survey.
COVID-19 necessitated rapid changes in methadone take-home policies in opioid treatment programs (OTPs); these changes markedly contrast with existing, long-standing federal mandates on OTP rules about take-home methadone. OTP providers describe how these changes have affected clinical decision-making, equity in patient care, and workflow. We also discuss implications for medical ethics and patient autonomy.
View Article and Find Full Text PDFCataract extraction has become a much safer procedure with the development of phacoemulsification, extending its application in ocular conditions such as glaucoma for better disease control. This review aims at summarizing the effect of lens extraction with or without combined glaucoma surgeries in different types of glaucoma and describing the intraoperative techniques and changes of glaucoma care postoperatively. A comprehensive literature search was performed through Medline and PubMed, and 67 studies were selected for this review.
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- Energetic metabolism reprogramming is essential for understanding cancer and immune responses, but traditional methods analyze cells in bulk, which can miss important details.
- The new technique, SCENITH, allows for detailed metabolic profiling at the single-cell level using flow cytometry, particularly effective for analyzing rare cells in whole blood without biases from cell culture.
- By applying SCENITH to myeloid cells in tumor samples, researchers discovered diverse metabolic profiles that didn’t correlate with cell lineage or activation, enhancing the potential for better therapeutic evaluation and patient treatment strategies.
Purpose: To examine predictors of health-related quality of life (HRQoL) in Hispanic and non-Hispanic White (NHW) breast cancer (BC) survivors.
Design: Cross-sectional study using survey data.
Participants: Women diagnosed with BC at ages 21-79 years, between 2012-2014, recruited from the New Jersey State Cancer Registry.
3D bioprinting is a powerful technique for engineering tissues used to study cell behavior and tissue properties in vitro. With the right formulation and printing parameters, bioinks can provide native biological and mechanical cues while allowing for versatile 3D structures that recapitulate tissue-level organization. Bio-based materials that support cellular adhesion, differentiation, and proliferation - including gelatin, collagen, hyaluronic acid, and alginate - have been successfully used as bioinks.
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- Many COVID-19 patients experience a range of symptoms, from mild to severe, and this study seeks to understand the differences in disease pathology between these groups.
- Mild COVID-19 patients show a consistent pattern of interferon-stimulated gene (ISG) expression across blood cells, while severe patients lack these cells despite having high levels of antibodies against the virus.
- Severe patients produce antibodies that block the creation of ISG-expressing cells, highlighting a dysfunctional immune response that could be targeted for new treatments.
Article Synopsis
- The study examines the differences between mild and severe COVID-19 cases, highlighting how patients with mild cases show a coordinated immune response while severe cases lack this.
- Severe COVID-19 patients have high levels of antibodies against the virus but also produce antibodies that disrupt the immune response associated with milder cases.
- The researchers suggest that the aggressive antibody responses in severe cases may harm the immune system's effectiveness, indicating potential targets for new immunotherapy treatments.
Objective: Embolo-sclerotherapy (EST) is the mainstay therapy for peripheral vascular malformations that involves the exposure of patients to ionizing radiation. We analyzed the radiation exposure to patients from EST of peripheral vascular malformations during a 5-year period in a single specialist center.
Methods: All patients who had undergone EST at a single specialist center for peripheral vascular malformations from January 1, 2013 to January 8, 2018 were identified from a prospectively collected database.
Objectives: In high-income countries, hazardous alcohol use is associated with reduced receipt of antiretroviral therapy (ART) and viral suppression among people living with HIV (PLHIV) who inject drugs. These associations are less understood in lower middle-income countries (LMIC) and upper middle-income countries.
Design: We examined associations between hazardous alcohol use, ART receipt, and viral suppression among PLHIV who reported current or former injection drug use.