Publications by authors named "Tsuboi J"
Article Synopsis
- Hereditary hemochromatosis (HH) is a serious iron-storage disorder that can cause significant organ damage, and HH type 3 is linked to mutations in the TFR2 gene, which is rare in Asia.
- A 69-year-old Japanese woman with joint pain and liver issues was found to have high iron levels and a novel homozygous mutation in her TFR2 gene, identified through genetic testing.
- After treatment with phlebotomy, her arthritis and liver enzyme levels improved, marking the first documented case of this specific mutation in an HH type 3 patient.
Article Synopsis
- A study compared inside stent (IS) and conventional stent (CS) for preoperative biliary drainage in patients with localized perihilar cholangiocarcinoma (LPHC) using data from 56 patients.
- Results showed that the IS group had significantly fewer instances of recurrent biliary obstruction (RBO), longer time to RBO, and needed fewer stent replacements compared to the CS group.
- Additionally, patients with IS experienced shorter hospital stays and lower overall costs preoperatively and postoperatively, indicating potential benefits for both patients and the healthcare system.
A 54-year-old woman presented with an elevated esophageal lesion. Computed tomography (CT) and magnetic resonance imaging revealed a mass in the pancreatic head. Endoscopic ultrasound (EUS) showed a well-defined, round, hypoechoic mass, which was considered lymph node enlargement.
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- The study investigates risk factors leading to painful colonoscopies and extended cecal intubation times specifically in female patients.
- Key findings highlight that women with sigmoid colon diverticulosis have a higher likelihood of experiencing pain during the procedure, while better tools (small-caliber colonoscopes) can reduce pain.
- Additionally, inadequate bowel preparation is linked to longer cecal intubation times, suggesting that preparation quality is crucial for a smoother procedure.
Article Synopsis
- * Recent studies suggest that selective screening and new biomarkers can enhance early diagnosis success rates.
- * Innovations in imaging, biomarker utility, and machine learning methods are improving risk identification and detection of pancreatic cancer and precancerous conditions.
Unlabelled: The global COVID-19 pandemic resulted in many jurisdictions implementing orders restricting the movements of people to inhibit virus transmission, with recreational angling often either not permitted or access to fisheries and/or related infrastructure being prevented. Following the lifting of restrictions, initial angler surveys and licence sales suggested increased participation and effort, and altered angler demographics, but with evidence remaining limited. Here, we overcome this evidence gap by identifying temporal changes in angling interest, licence sales, and angling effort in world regions by comparing data in the 'pre-pandemic' (up to and including 2019); 'acute pandemic' (2020) and 'COVID-acclimated' (2021) periods.
View Article and Find Full Text PDFPancreatic mixed neoplasms are very rare. We herein report a unique case of pancreatic mixed acinar-neuroendocrine-ductal carcinoma with trilineage differentiation. The patient was an 83-year-old woman referred to our hospital due to anemia and a pancreatic mass.
View Article and Find Full Text PDFA 68-year-old female patient was referred to our hospital with a 30-mm polyp in the second portion of the duodenum found via esophagogastroduodenoscopy. The polyp had an irregular, lobular surface and a thick stalk. In addition, white dots were detected on the surface.
View Article and Find Full Text PDFBackground: Endoscopic submucosal dissection (ESD) for superficial esophageal cancer is technically challenging, and research on predictive factors related to the difficulty in the procedure is limited. This study aimed to investigate the factors predicting the difficulty in esophageal ESD.
Methods: This retrospective study analyzed 303 lesions treated at our institution between April 2005 and June 2021.
Article Synopsis
- This study investigates the relationship between cecal intubation time during colonoscopy and the detection of adenomas, which are precursors to cancer.
- The research analyzed data from 216 female patients, revealing that longer cecal intubation times were linked to a significant decrease in the mean number of adenomas found.
- The findings suggest that cecal intubation time could serve as an important quality measure for colonoscopy procedures.
Superficial epithelial gastric neoplasms can be divided into adenomas and early carcinomas. Histological diagnosis by endoscopic forceps biopsy is crucial for the diagnosis and management of gastric neoplasms. It is difficult to distinguish features of gastric neoplasms in small biopsy specimens; hence, gastric carcinomas can be underdiagnosed as adenomas.
View Article and Find Full Text PDFObjective: Subdural hemorrhage (SDH) has been reported to be the most frequent intracranial hemorrhagic complication following open heart surgery; however, its clinical features and pathophysiology remain unclear. The aim of this retrospective study was to elucidate the incidence, clinical course, and factors associated with the development of symptomatic SDH following heart valve surgery.
Methods: A retrospective review of medical records on the development of symptomatic SDH after heart valve surgery involving cardiopulmonary bypass (CPB) from April 2011 to March 2016 was performed.
Magnifying endoscopy with narrow band imaging (M-NBI) was developed to diagnose Barrett's esophageal adenocarcinoma (BEA); however, this method remains challenging for inexperienced endoscopists. We aimed to evaluate a modified M-NBI technique that included spraying acetic acid (M-AANBI). Eight endoscopists retrospectively examined 456 endoscopic images obtained from 28 patients with 29 endoscopically resected BEA lesions using three validation schemes: Validation 1 (260 images), wherein the diagnostic performances of M-NBI and M-AANBI were compared - the dataset included 65 images each of BEA and non-neoplastic Barrett's esophagus (NNBE) obtained using each modality; validation 2 (112 images), wherein 56 pairs of M-NBI and M-AANBI images were prepared from the same BEA and NNBE lesions, and diagnoses derived using M-NBI alone were compared to those obtained using both M-NBI and M-AANBI; and validation 3 (84 images), wherein the ease of identifying the BEA demarcation line (DL) was scored via a visual analog scale in 28 patients using magnifying endoscopy with white-light imaging (M-WLI), M-NBI, and M-AANBI.
View Article and Find Full Text PDFFollowing injury, skeletal muscle regenerates but fatty tissue accumulation is seen in aged muscle or muscular dystrophies. Fibro/adipogenic progenitors (FAPs) are key players in these events; however, the effect of primary cilia on FAPs remains unclear. Here, it is reported that genetic ablation of trichoplein (TCHP), a ciliary regulator, induces ciliary elongation on FAPs after injury, which promotes muscle regeneration while inhibiting adipogenesis.
View Article and Find Full Text PDFDedifferentiated liposarcoma in the abdominal cavity: a case report.
Clin J Gastroenterol
December 2022
Article Synopsis
- - Liposarcoma attached to the mesentery is very rare and often hard to properly diagnose, as seen in a 70-year-old woman who had a mass in her right lower abdomen.
- - After surgery to remove the mass, she was found to have dedifferentiated liposarcoma originating from the transverse colon and began chemotherapy.
- - Diagnosing this type of cancer based solely on imaging is difficult, so surgery can help; additionally, genetic testing was done since new treatments for dedifferentiated liposarcoma are being researched.
Article Synopsis
- A 64-year-old man with diabetes and gallstones was suspected of having pancreatic cancer after imaging showed cysts and fluid accumulation around the abdomen.
- Further evaluation through endoscopic ultrasonography identified a mass in the pancreas, but biopsy results did not show cancer, leading to a suspicion of type 1 autoimmune pancreatitis.
- The patient was treated with prednisolone, and follow-up CT scans after 11 days showed a reduction in the size of the cysts and ascites.
Article Synopsis
- Endoscopic submucosal dissection (ESD) is an effective, minimally invasive treatment for superficial esophageal cancer (SEC) that often results in complete tumor removal.
- This study analyzed the outcomes of ESD in 318 SEC patients, comparing those who had undergone gastrectomy to those who hadn't, using propensity-score matching to reduce bias.
- Results showed no significant differences in key outcomes such as resection rates, procedure duration, hospitalization time, or recurrence between gastrectomized and non-gastrectomized patients, suggesting gastrectomy history does not adversely affect ESD effectiveness.
Stream-dwelling white-spotted charr, , populations tend to have unique color and spot patterns in different regions and may even display stream-specific patterns. An extreme edge of such diversity, found in individuals with atypical body color patterns (so-called nagaremon-type charr, a rare morphotype of [hereafter termed nagaremon-charr]), sympatrically occurring with normal-charr, has been reported from only six small isolated populations in Japan. Based on morphological and ecological perspectives, nagaremon-charr has been considered as an intraspecific color variant of white-spotted charr, although the genetic status of nagaremon-charr has not been determined.
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- Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer deaths globally, and improving diagnostic accuracy is crucial for effective treatment.
- The study developed a new algorithm called Mathematical Technology for Cytopathology (MTC), which enhances cytological diagnosis without needing extensive resources or trained personnel.
- Results showed that the MTC algorithm could accurately differentiate between pancreatic adenocarcinoma and benign tissues, achieving over 70% accuracy in multiple analyses, indicating its potential for improving clinical diagnostics.
Background: This study aimed to clarify the features of superficial non-ampullary duodenal epithelial tumors (SNADETs) on magnifying endoscopy with narrow-band imaging (M-NBI) and magnifying endoscopy with acetic acid and narrow-band imaging (M-AANBI), and evaluate the efficacy of M-NBI/M-AANBI to distinguish high-grade adenomas or adenocarcinomas (HGA/AC) from low-grade adenomas (LGA).
Methods: Clinicopathological data on 62 SNADETs in 58 patients who underwent preoperative M-NBI/M-AANBI and endoscopic resection were retrospectively reviewed. The pathological results were classified into two categories, LGA and HGA/AC.
Background: Pancreatic cancer is associated with high mortality and its rates of detection are very low; as such, the disease is typically diagnosed at an advanced stage. A number of risk factors for pancreatic cancer have been reported and may be used to identify individuals at high risk for the development of this disease.
Objective: The aim of this prospective, observational trial is to evaluate a scoring metric for systematic early detection of pancreatic cancer in Mie Prefecture, Japan.
The introduction of anti-inflammatory therapies has enabled substantial improvement of disease activity in patients with inflammatory bowel diseases (IBD). However, IBD can lead to serious complications such as intestinal fibrosis and colorectal cancer. Therefore, novel therapies reducing the development of these complications are needed.
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- The study focuses on improving the detection of pancreatic ductal adenocarcinoma (PDAC) by examining proteins found in extracellular vesicles (EVs) extracted from biopsy samples.
- Researchers isolated EV proteins from samples of 40 PDAC patients and compared them to those from 6 autoimmune pancreatitis patients, identifying a total of 2,059 proteins uniquely associated with PDAC.
- The findings revealed 153 proteins that differed significantly between PDAC and autoimmune pancreatitis, with some proteins showing potential as biomarkers for diagnosing and staging PDAC, particularly in advanced stages.
Article Synopsis
- Female patients often experience increased pain during unsedated colonoscopy, prompting this study to test a small-caliber colonoscope, PCF-PQ260 L, for pain reduction.
- The study involved 220 women, split between the small-caliber and standard colonoscopy groups, with results showing that those using the small-caliber scope reported significantly lower overall and maximum pain scores.
- Additionally, the small-caliber colonoscope not only improved the success rate of the procedure but also increased the likelihood of women opting for unsedated colonoscopies in the future.