Publications by authors named "Tsion Aberra"
Article Synopsis
- * Accurate pre-transplant screening for Chagas disease is essential, but challenges arise due to the variability of tests and their effectiveness.
- * A case study highlights a patient who initially tested negative for Chagas after a commercial antibody test but later showed reactivation post-transplant, emphasizing the need for thorough testing.
Background: Elevated triglycerides (TGs) are associated with increased risk of cardiovascular disease (CVD), but the best way to both measure TGs and assess TG-related risk remains unknown.
Objective: The objective of the study was to evaluate the association between TGs and CVD and determine whether the average of a series of TG measurements is more predictive of CVD risk than a single TG measurement.
Methods: We examined 15,792 study participants, aged 40-65 years, free of CVD from the Atherosclerosis Risk in Communities and Framingham Offspring studies, using fasting TG measurements across multiple examinations over time.
Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains elusive.
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- The study explores the links between chronic stress, as measured by resting amygdala activity, and various cardiovascular health markers in patients with psoriasis, a stress-related inflammatory condition.
- Researchers analyzed data from 164 psoriasis patients and 47 healthy participants, using advanced imaging techniques to assess amygdala and hematopoietic system activity along with cardiovascular indicators.
- Results showed higher amygdala activity in psoriasis patients, correlating with increased hematopoietic activity and subclinical cardiovascular disease markers; treatment of severe psoriasis led to improvements in both skin condition and stress-related measures over one year.
Article Synopsis
- Inflammation plays a key role in the development of atherosclerosis, and psoriasis serves as a model to study early cardiovascular issues due to its association with chronic inflammation.
- This study aims to explore the relationship between aortic vascular inflammation (VI) and various coronary artery disease (CAD) indices in patients with psoriasis.
- Results showed that increased aortic VI correlates with a higher total plaque burden, more luminal stenosis, and a greater presence of high-risk plaques, suggesting a potential link between chronic inflammation and early CAD development.
Article Synopsis
- Inflammation is a key factor in the development of atherosclerosis, and psoriasis, a chronic inflammatory skin disease, is linked to increased vascular inflammation and future cardiovascular issues.
- The study aimed to examine the relationship between the severity of skin disease (measured by PASI score) and vascular inflammation after one year of anti-tumor necrosis factor therapy.
- In a cohort of 115 patients, significant improvements in both skin condition and vascular inflammation were observed, with most patients experiencing a notable decrease in PASI scores and vascular inflammation over the year.
Background: Psoriasis, a chronic inflammatory disease associated with an accelerated risk of myocardial infarction, provides an ideal human model to study inflammatory atherogenesis in vivo. We hypothesized that the increased cardiovascular risk observed in psoriasis would be partially attributable to an elevated subclinical coronary artery disease burden composed of noncalcified plaques with high-risk features. However, inadequate efforts have been made to directly measure coronary artery disease in this vulnerable population.
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- GlycA is an inflammatory biomarker that has been linked to cardiovascular events and is being studied in relation to psoriasis, a condition that heightens cardiovascular risk.
- A study involving 412 participants found that GlycA levels were significantly higher in psoriasis patients compared to controls, with levels correlating to the severity of the disease.
- GlycA was also shown to predict vascular inflammation and coronary artery disease independently of traditional cardiovascular risk factors in psoriasis patients, and anti-inflammatory treatment reduced both psoriasis severity and GlycA levels.
Article Synopsis
- Psoriasis is linked to chronic inflammation and an increased risk of heart problems, and patients with psoriasis often experience depression, raising questions about the impact of depression on vascular health.
- A study matched psoriasis patients with and without reported depression to analyze vascular inflammation and coronary plaque using advanced imaging techniques and statistical methods.
- Findings showed that patients with self-reported depression had higher vascular inflammation and greater coronary plaque burden, suggesting depression could enhance the risk of heart disease in those with psoriasis, despite controlling for traditional risk factors.