Publications by authors named "Tsiogka A"
Introduction: Results from randomized controlled trials of upadacitinib, a Janus kinase (JAK) inhibitor, have led to its approval for the treatment of moderate-to-severe atopic dermatitis (AD) in patients aged ≥ 12 years. The aim of this study was to report the effectiveness and safety of upadacitinib in real-world settings over a period of 96 weeks.
Methods: This retrospective study included all patients treated with upadacitinib at our centre between April 2022 and September 2024.
Corneal and anterior segment parameters in patients with clinically unilateral pseudoexfoliation syndrome.
Med Hypothesis Discov Innov Ophthalmol
August 2024
Background: Pseudoexfoliation syndrome (PES) is an age-related systemic condition that predominantly affects ocular structures and is characterized by the deposition of material on the lens, ciliary body, zonules, corneal endothelium, iris, and pupillary margin. We compared the corneal endothelial morphology, anterior segment parameters, corneal densitometry, and corneal topographic characteristics between the clinically affected and apparently normal fellow eyes of patients with clinically unilateral PES.
Methods: This was a comparative, cross-sectional study of 34 patients with clinically unilateral PES.
Tinea incognito is a dermatophyte infection with atypical features, due to the use of topical or systemic steroids or other immunosuppressive medications. Delayed diagnosis, spread of the infection to critical body surfaces, resistance to antifungal drugs, and increased costs due to prolonged hospitalization and multiple treatment regimens often complicate tinea incognito. It can affect individuals of all ages and genders, but it is more common in children.
View Article and Find Full Text PDFEuroGuiderm guideline on lichen sclerosus-Treatment of lichen sclerosus.
J Eur Acad Dermatol Venereol
October 2024
Article Synopsis
- Lichen sclerosus (LS) is a skin condition primarily affecting the anogenital area, causing symptoms like itching, soreness, and potential sexual and urinary dysfunction, with a risk of genital cancer and significant impacts on quality of life.
- The guideline aims to improve the diagnosis and treatment of LS, offering evidence-based recommendations for different therapies and care approaches, especially during pregnancy and follow-up.
- Topical corticosteroids are the primary treatment for LS in both sexes, with surgery as an option for males if standard treatments fail, while UV light therapy is suggested for non-genital LS, despite limited research.
EuroGuiderm guideline on lichen sclerosus-introduction into lichen sclerosus.
J Eur Acad Dermatol Venereol
October 2024
Article Synopsis
- Lichen sclerosus (LS) is an inflammatory skin condition primarily affecting the anogenital area, leading to symptoms like itching, soreness, and potentially serious complications such as urinary and sexual dysfunction, along with an increased risk of genital cancer.
- *The guideline aims to provide a comprehensive approach for diagnosing and treating LS, including recommendations for topical and surgical treatments, as well as care considerations for patients during pregnancy and ongoing management.
- *Topical corticosteroids are considered the standard treatment for LS, with additional options like emollients and, if ineffective, surgical interventions such as circumcision for males; UV light therapy is also suggested for non-genital forms of LS despite limited evidence.
Interleukin antagonists for atopic dermatitis: a new era of therapy.
Expert Opin Investig Drugs
June 2024
Article Synopsis
- Recent advances in understanding the immunopathogenesis of atopic dermatitis (AD) have led to the development of new immune-based therapies, particularly interleukin (IL) antagonists like dupilumab and tralokinumab, which are now approved for use in Europe.
- This review examines the role of various interleukins in AD's development and assesses the efficacy and safety of newer and investigational IL-antagonists for treating moderate-to-severe forms of the condition.
- Although current IL-4 and IL-13 inhibitors show promise for quick flare control and long-term relief, more research is needed on additional IL-inhibitors and real-world effectiveness, alongside establishing predictive biomarkers for personalized treatment plans.
Purpose: The purpose of this study was to investigate the associations between central corneal endothelial cell density (ECD), endothelial morphology, and corneal thickness (central corneal thickness) with the anterior chamber depth, corneal volume (CV), white-to-white (WTW) distance, mean anterior chamber angle (CAmean), and gender in healthy individuals.
Methods: This observational study included 136 healthy volunteers. The ECD, coefficient of variation of cell area, and hexagonal cell appearance ratio (%Hex) were measured by means of specular microscopy.
Data on switching between agents in patients with atopic dermatitis (AD) are scarce (1-3). We report the case of a patient with severe AD and inadequate response to upadacitinib who showed a complete response after switching to abrocitinib. A 23-year-old male patient with severe AD was enrolled in the Measure Up double-blind, placebo-controlled, phase 3 randomized clinical trial.
View Article and Find Full Text PDFArticle Synopsis
- * Recent research suggests that starting systemic treatments early might significantly improve AD management, potentially altering the disease's progression and improving patients' overall health outcomes.
- * By addressing itching at its source, early systemic intervention can reduce systemic inflammation, prevent complications, and lessen the mental and emotional toll of the disease, paving the way for better long-term control strategies for patients.
Purpose The purpose of this study is to investigate the effect of two yellow filters (category 1: visible light transmission {VLT} from 80% to 43%) of Essilor (Kiros® and Lumior®) on standard automated perimetry (SAP) indices and Pelli-Robson (PR) contrast sensitivity (CS) testing in healthy individuals. Materials and methods This study is a prospective comparative study of 31 eyes of 31 healthy individuals aged 32.14 (8.
View Article and Find Full Text PDFDarier disease responding to apremilast: Report of two cases.
Indian J Dermatol Venereol Leprol
January 2024
Aim: To evaluate the alterations of the retinal microvasculature and foveal avascular zone in patients with Parkinson's disease (PD) using optical coherence tomography angiography (OCT-A).
Methods: A retrospective study of PD patients examined in the Ophthalmology Department of the General Hospital of Athens, "Georgios Gennimatas" from March 2021 to March 2022 was conducted. Totally 44 patients with PD were included and 18 healthy controls were examined, hence a total of 124 eyes were enrolled in the study.
Article Synopsis
- - Fungal keratitis is a serious eye infection that can lead to vision loss, making early diagnosis essential for treatment.
- - Patient history and symptoms help in creating a clinical suspicion, while a slit-lamp examination, microbiological tests, and advanced techniques like PCR and OCT are important for accurate diagnosis.
- - Each diagnostic method has its pros and cons, and the choice of technique depends on the clinical situation, available resources, and the expertise of the healthcare provider.
Background: The TsiogkaSpaeth (TS) grid is a new, low-cost, and easy to access portable test for visual field (VF) screening which could be used by clinicians in everyday clinical practice. Our study aimed to determine the validity of an innovative screening grid test for identifying neurological disease-associated VF defects.
Methods: We enrolled two groups of participants: We assessed the one eye of ten consecutive adult patients with different types of neurological disease associated VF defects and ten eyes of controls in each group.
Article Synopsis
- The study evaluates the effectiveness and safety of botulinum toxin type A (BoNT-A) for treating primary plantar hyperhidrosis (PPH), based on the analysis of records from 129 patients over nearly two decades.
- Most patients (89.1%) received onabotulinumtoxin-A, averaging around 2 sessions, with a mean response duration of about 6 months, showing a positive response rate over time.
- The majority of patients reported being satisfied with the treatment, and no serious side effects were noted, indicating that BoNT-A is a viable option for managing PPH.
(1) Background: The current study aimed to compare two of the most frequently prescribed preservative-free (PF) antiglaucoma drops, (Latanoprost PF vs. Bimatoprost PF) in promoting OSD in patients with POAG. (2) Methods: In this prospective study, 44 eyes from 44 participants were included.
View Article and Find Full Text PDFBackground: Subungual melanoma (SUM) is a rare type of cutaneous malignant melanoma (CMM) associated with poor prognosis, while data regarding its prevalence are scarce.
Objectives: We sought to provide a comprehensive systematic review and meta-analysis of the prevalence rates of SUM among all types of CMM, considering certain demographic and clinical characteristics.
Methods: The MEDLINE electronic database was searched systematically to identify eligible studies providing prevalence rate estimates of SUM in patients with CMM.
Article Synopsis
- This study focuses on paradoxical psoriasis (PP) observed in patients with hidradenitis suppurativa (HS) who switched from adalimumab to other biologics targeting interleukin (IL)-17/IL-23.
- Of the 83 patients treated with adalimumab, 10 (12%) developed skin reactions resembling psoriasis after a median of seven months.
- Following the switch to IL-17/IL-23 inhibitors, most patients saw improvements in both HS and PP symptoms.
Introduction: To assess the clinical benefits obtained with transcutaneous low-power, high-frequency quantum molecular resonance (QMR) electrotherapy in a group of multifactorial dry eye patients.
Methods: Fifty-one patients (total of 102 eyes) with dry eye symptoms were enrolled in the study. Included clinical conditions were meibomian gland dysfunction, glaucoma, cataract surgery within the past six months, and autoimmune disease-related superficial punctuate keratitis.