Abstracts of the 16th European Congress of Paediatric and Adolescent Gynaecology .

PAG aims to foster a collaborative environment that bridges knowledge from various disciplines to ensure the highest quality of care for children and adolescents with gynaecological issues. The European Association of PAG and HellenicPAG, like all National PAG Societies, support research and education to advance new insights, improve health outcomes, enhance quality of life, and protect future fertility. Additionally, PAG promotes international cooperation by proposing guidelines for good clinical practice in terms of prevention, diagnosis, procedures, and treatment.

Alleviation of vulvovaginitis symptoms: can probiotics lead the treatment plan?

Disruption of vaginal microbiota equilibrium promotes infectious clinical syndromes with annoying symptoms, such as vaginal discharge, odour, irritation, pruritus, and vulvar burning. Although identifying and eradicating the pathogen involved has been the standard of care, regional microbiota restoration with probiotics has been gaining ground in recent years. This study aimed to assess the effectiveness of topical treatment for patients exhibiting vaginal discomfort symptoms.

Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Female Adolescents.

The gene is considered the most dysregulated in obese human fat. Limited data suggest that the novel peptide spexin may potentially impact food intake, weight regulation and body adiposity. The aim of this case-control study was to compare fasting serum spexin concentrations between normal weight (NW) and overweight/obese (OB/OW) adolescent females and explore the relationship between circulating spexin and anthropometric, bone and fat mass, metabolic and hormonal parameters.

Resolution of Hematocolpos in Adolescents Affected with Graft vs Host Disease.

Background: Bone marrow transplantation is a lifesaving procedure for a range of serious benign or malignant hematological conditions. A proportion of patients, however, will develop graft vs host disease (GVHD), acute or chronic, with serious long-term sequalae.

Cases: We present 2 cases of hematocolpos that developed in adolescence because of vaginal synechiae due to GVHD.

The effect of hormone therapy on biochemical and ultrasound parameters associated with atherosclerosis in 46,XY DSD individuals with female phenotype.

The aim of this study was to evaluate the effect of hormone therapy (HT) in the endothelial function of 46,XY disorders of sexual development (DSD) patients with female phenotype. Biochemical and ultrasound measurements were performed in 20 patients at initiation of oral 2 mg 17β-estradiol/1 mg norethisterone acetate, and after 6 months of therapy. Lipid profile, including total cholesterol (TC), LDL, HDL, triglycerides (TG) and Atherogenic Index of Plasma (AIP), as well as levels of VE-Cadherin, E-Selectin, Thrombomodulin and vWf were determined.

Application of Creatsas vaginoplasty after radical surgical treatment of sarcoma botryoides.

Background: Sarcoma botryoides of the female genital tract is a rare malignancy. For many years, treatment consisted of radical procedures involving removal of the vagina, cervix, and uterus. Reconstructive surgery is essential for these patients, in order to achieve vaginal penetrative sexual intercourse.

Long-term followup of adolescent and young adult females with hypergonadotropic hypogonadism.

The condition characterized by elevated gonadotrophins (gonadotropins elevated into the menopausal range), low sex steroids, and menstrual disorders was previously termed Premature Ovarian Failure (POF). However, over the last two years an effort has been made by many authors to have the term Primary Ovarian Insufficiency (POI) exclusively applied. Irrespective of the term, the condition concerns adolescent and young adult women under 40 years who experience cessation of menstruation for more than 3 cycles (whereas these women in the past had a rhythmic menstrual cycle) or amenorrhea for 4-6 months against the background of a previously disturbed menstrual cycle.

Successful pregnancy in a Swyer syndrome patient with preexisting hypertension.

Objective: To report a case of a successful pregnancy and delivery of a patient with 46,XY pure gonadal dysgenesis (Swyer syndrome) and preexisting chronic hypertension who underwent in vitro fertilization (IVF) and embryo transfer (ET).

Design: Case report and review of the literature.

Setting: 2nd Department of Obstetrics and Gynecology, University of Athens, Medical School, "Aretaieion" Hospital.

Evaluation and management of adolescent amenorrhea.

During the first years of menstruation it is not rare for a girl to present with an irregular menstrual pattern. The complete absence or cessation of menses, which is defined as amenorrhea, requires careful evaluation and management. It is divided into primary and secondary types that describe the occurrence of amenorrhea before and after menarche, respectively.

Menstrual disturbances in puberty.

The most significant corporal change observed in adolescent girls is the onset of menstruation, which occurs between 12 and 13 years of age. In several cases, described with the term 'precocious puberty', pubertal development can begin at a significantly younger age. The term 'delayed puberty' refers to absence of pubertal development in a girl over the age of 14.

Vaginal foreign body in childhood: A multidisciplinary approach.

A 5-year-old girl referred to our division for evaluation of persisting foul-smelling brown vaginal discharge with pruritus for over 2 years, not corresponding to antibiotic therapy. Transabdominal ultrasound identified a heterogeneous mass intensely fixed in the upper third of vaginal wall. Vaginography revealed a filling defect in the upper part of vagina, confirming the diagnosis of an intravaginal foreign body.

Menstrual disorders during adolescence.

During the post-menarcheal years several kinds of menstrual disorders can be observed, such as abnormal uterine bleeding, primary and secondary dysmenorrhea, premenstrual syndrome, primary and secondary amenorrhea and oligomenorrhea. Abnormal uterine bleeding and especially the subtype of dysfunctional uterine bleeding is the most urgent gynecological problem during adolescence, while dysmenorrhea is the most frequent one for which adolescents and their parents refer to a physician. Normal menstrual cycle physiology as well as definitions of all the above menstrual disorders is briefly mentioned before going on with dysfunctional uterine bleeding and dysmenorrhea.