Publications by authors named "Tshiamo T Maluleke"
Systemic inflammation contributes to left ventricular (LV) dysfunction, however the role of the NLRP3 inflammasome in LV dysfunction in acute inflammatory conditions is unclear. This study investigated the role of the NLRP3 inflammasome in acute (24 h) cardiac structural and functional changes in vivo and in vitro in lipopolysaccharide (LPS)-induced inflammation. LPS-treated Sprague-Dawley (SD) rats showed increased LPS metabolite abundance in their LVs as measured by atmospheric pressure matrix-assisted laser desorption ionisation (AP-MALDI) mass spectrometry imaging (MSI).
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- - The study examined how collagen-induced arthritis (CIA) affects brain regions by analyzing molecular markers linked to inflammation and neuron dysfunction.
- - Fourteen male rats were used, with nine having CIA and five as controls; after 10 weeks, brain tissue was analyzed for changes in inflammatory and neurotrophic markers, as well as neurotransmitter levels.
- - Results showed that CIA led to increased inflammation and altered expression of key markers, indicating neurodegeneration, along with decreased levels of serotonin and dopamine in specific brain regions.
Objective: Estrogen deficiency is associated with left ventricular (LV) dysfunction in postmenopausal women and ovariectomized rats. Whether the relationship between estrogen deficiency and LV dysfunction is independent of cardiovascular disease (CVD) risk factors remains uncertain. This study assessed the effects of short-term and long-term estrogen deficiency on cardiac structure and function using conventional and speckle tracking echocardiography, independent of traditional CVD risk factors.
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